Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 409 for “"human cells"”.
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Telomere Position Effect in Human Cells
… the action of the enzyme telomerase. Most human somatic cells lack telomerase activity and so continued cell division leads to telomere shortening. After a limited number of divisions (the "Hayflick limit"), it is believed that a few critically shortened telomeres trigger a state of growth …
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Neotelomere Formation by Telomerase in Human Cells
… chromosomes. Genome stability requires that cells differentiate telomeres from DNA double-strand breaks (DSBs), which humans accomplish with the shelterin complex. The reverse transcriptase telomerase counteracts the shortening of telomeres that occurs with cell division due to incomplete DNA …
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A-to-I RNA Editing in Human Cells
… and exogenous RNA. Of the three ADAR homologs in humans, dysregulation of ADAR1 editing due to inherited mutations leads to disorders such as Aicardi-Goutieres syndrome, an inflammatory disease that manifests in the brain and skin, and dyschromatosis symmetrica hereditaria, a skin pigmentation …
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Directed evolution in human cells via adenoviral replication
… biomolecules that reliably function in metazoan cells is imperative for both basic biological research, and therapeutic development. Typically, researchers turn to directed evolution either in vitro, in bacteria, or in yeast, to mutate, select, and amplify biomolecules of interest (BOls) with new …
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Transcriptomic profiling of human cells destined for therapeutic applications
… focused on the use of mesenchymal stromal cells (MSCs) as a cell therapy for various diseases with unmet medical challenges, including graft-vs-host disease, osteoarthritis, autism, and auto-immune diseases. MSCs are multipotent cells that have both regenerative and immunomodulatory …
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Ultrastructural analysis of HIV-1 infection in human cells
Das Humane Immundefizienz-Virus (HIV) ist der Auslöser des erworbenen Immundefizienz-Syndroms (acquired immune deficiency syndrome, AIDS). HIVInfektion, weltweit eine der problematischsten Infektionskrankheiten, betrifft etwa 40 Millionen Menschen und tötet schätzungsweise 3 Millionen Menschen …
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An integrated CRISPR-Cas toolkit for engineering human cells
… CRISPR/Cas transcription factors (CRISPR-TFs) in human cells. By integrating CRISPR-TFs and Cas6/Csy4 based RNA processing with multiple mammalian RNA regulatory strategies including RNA Polymerase II (RNAP II) promoters, RNAtriple- helix structures, introns, microRNAs and ribozymes, we …
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Investigating the Molecular Mechanisms Underlying Ku Essentiality in Human Cells
… across mammalian species, Ku is essential for human cell viability but is dispensable in mice. Essentiality in human cells was previously suggested to be due to Ku’s role in maintaining human telomere length. To study the underlying cause of Ku’s essentiality in humans, a conditional Ku70 …
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Retroviral-Medicated Transfer of Suppressor tRNA Genes Into Human Cells
… genes have been associated with a variety of human diseases. A useful therapeutic approach to correct such mutations may be to introduce genes expressing suppressor tRNA that recognize the premature stop codon, insert the appropriate amino acid, and allow translation of a full-length, …
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An in vivo study of chromatin compaction in human cells
… chromosomes. The arrangement of chromatin within cells, with respect to its compaction state, has a number of implications for processes like transcription, DNA replication, DNA repair and more recently, in vision of nocturnal animals. <br/><br/>Most work on the study of chromatin compaction has …
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Mechanisms of dynein-based mRNA transport processes in human cells
Protein function in cells is intricately regulated in both space and time through the positioning of mRNA molecules in the cytoplasm. This process is commonly mediated by molecular motors, which transport mRNAs along the cytoskeleton to specific cellular regions. Despite the widespread occurrence …
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Determining the Molecular Underpinnings of Iron Homeostasis in Human Cells
… the necessary cytoplasmic iron concentration, cells store excess iron in large proteinaceous cages called ferritin and, when available iron levels fall, they degrade these cages, liberating the stored iron for use. This thesis focuses on the molecular mechanisms underlying cellular iron …
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Engineering of tools for De Novo Assembly of Human Cells
… methods, such as organoids, induce pluripotent cells to differentiate into aggregates that resemble their in vivo counterparts, yet the size and complexity of these structures are limited by nutrient diffusion and the morphology cannot be controlled. An ideal system would allow for high spatial …
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Mutational spectra of MNNG and ICR-191 in human cells
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Applied Biological Sciences, 1988.
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Variations in Mevalonate Pathway Flux in Human Cells with Familial Hypercholesterolemia
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Gcn5 Loss Impacts Myc-Driven Cancer In Mice and Human Cells
… genes of GCN5 and c-MYC in mouse embryonic stem cells. Recent studies have also implicated GCN5 in enhancing progression of several different cancers. We hypothesize that GCN5 functions are also linked to those of MYC isoforms in cancer.</p> <p>Triple negative breast cancers typically overexpress …
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Expression from the parvovirus B19 promoters in non-permissive human cells
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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A comprehensive survey of somatic mutation landscapes in normal human cells
… liver hepatocytes. Interestingly, post-mitotic cells such as the heart, cerebellum, skeletal muscle, and adipose tissue accumulate somatic mutations at a rate similar to that of their actively dividing counterparts. Additionally, epithelial cells exhibit different mutation accumulation rates …
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Interactions and Functions of the Ubiquitin Specific Protease 7 in Human Cells
… approach to profile USP7 interactions in cancer cells. This confirmed reported associations of USP7 with USP11, PPM1G phosphatase and TRIP12 and identified novel interactions with FBXO38 and two DEAD/DEAH-box RNA helicases, DDX24 and DHX40. I show that USP11, PPM1G, DDX24, TRIP12 and FBXO38 bind …
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