Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 251 for “"human cancer"”.
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Collagen gene expression in human cancer
… was extracted from different stages of breast cancer and adjacent normal tissue for analysis of collagen gene expression by Northern blot hybridisation. Stage I breast tumours had increased α1(I) and α2(I) collagen mRNA, whereas stages II and III tumours had decreased mRNA levels when compared …
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Telomere Length Studies in Human Cancer Cells
… time the cells undergo senescence or apoptosis. Cancer cells which have the ability to divide indefinitely must prevent their telomeres from becoming critically short, and the majority of cancer cells achieve this by upregulating telomerase. Maintaining telomere length involves regulating the …
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Normal cell signals in human cancer transcriptomes
Cancer cells arise from normal cells, and may retain transcriptional patterns present in the cell of origin. Recent advances in single-cell transcriptomics have allowed us to profile both normal and cancer cells at a single cell resolution, enabling direct comparisons between the two. Such …
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Regulation of apoptosis in human cancer cells
Nitric oxide is postulated to protect cancer cells from the death-inducing effects of tumour necrosis factor alpha by S-nitrosating the active site cysteines, inhibiting cleavage of caspase-9. We aimed to test this hypothesis and to determine its validity across cancer cell types. In addition, we …
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Ras Intrinsic and Extrinsic Pathways in Human Cancer
… is aberrantly activated in a majority of human cancers either through an activating mutation or by activation or overexpression of upstream or downstream elements in the Ras pathway, endowing cells with many tumorigenic phenotypes. Ras is known to promote tumorigenesis through activation …
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DNA G-quadruplex structures in human cancer cells
… present new opportunities for targeting in anti-cancer therapeutic interventions with small molecules. In this thesis, I expand the G4-profiling toolkit to better understand the biological roles of G4s, and potentially offer practical insights for G4-targeting drug development. First, …
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Patterns of somatic genome rearrangement in human cancer
Cancer development is driven by somatic genome alterations, ranging from single point mutations to larger structural variants (SV) affecting kilobases to megabases of one or more chromosomes. Studies of somatic rearrangement have previously been limited by a paucity of whole genome sequencing data, …
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Characterisation of RNA modifications in human cancer cells
… to a wide range of biological processes and human diseases, such as cancer. However, the vast majority of these modifications are uncharacterised, defined on limited substrates and are subject to enzymatic pathways. This shortfall is partly due to lack of reagents and technologies to study …
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Analysis of alterations in the human cancer genome
… chromosomes, is present in approximately 90% of human malignancies. Despite over 100 years of research, many questions remain regarding the contribution of aneuploidy to the cancer phenotype. In this thesis, we develop computational methods to infer the presence and specific patterns of …
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Nuclear Factor Kappa B Pathway and human cancer therapeutics
Cancer is one of the major causes of morbidity in the world. Although the overall survival of cancer has been significantly improved by chemotherapy in the last three decades, the success of cancer chemotherapy is still severely limited by the lack of selectivity of anti-cancer drugs to malignant …
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Tissue Transglutaminase And Its Role In Human Cancer Progression
… whose expression is up-regulated in several human cancers. Here I show that tTG is a key participant in a novel EGFR/Src-signaling pathway and a potential target for inhibiting EGFR-promoted tumor progression. Specifically, EGF up-regulates tTG expression in human breast cancer cells, and …
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Reverse-Engineering of Genetic Regulatory Pathways in Human Cancer
… RNA sequencing, have been widely used in cancer research and have provided valuable insights into the molecular mechanisms underlying cancer. The research presented in this thesis uses data-driven computational models to interpret tumour gene expression information in the context of …
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Evidence of Human Endogenous Retrovirus K Involvement In Human Cancer
… serum, and tissue samples from invasive breast cancer (N=19), ductal carcinoma</p> <p><em>in situ </em>(N=13), malignant ovarian cancer (N=12), and benign ovarian tumors (N=9), via IRB-approved and informed consent protocols through M.D. Anderson Cancer Center, as well as normal donor plasmas …
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Cytotoxic Effects of Ruthenium Compounds on Human Cancer Cell Lines.
<p>Chemotherapy is the most common cancer treatment. Traditionally, platinum-based drugs are used in chemotherapy. More recently, researchers have focused on ruthenium based compounds as a substitute for the platinum compounds. Ruthenium-based compounds appear to be less toxic to healthy cells than …
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Studies of the UNC-45A Molecular Chaperone Expression in Human Cancer
… UNC-45A mRNA and protein expression elevated in human cell lines derived from breast carcinoma metastases. UNC-45A knockdowns decreased breast cancer cells proliferation and invasion rates. We also indicated that UNC-45A(a) existed as two isoforms – UNC-45A(a) 929 and 944 – in mammalian cells. …
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Studies of the UNC-45A Molecular Chaperone Expression in Human Cancer
… UNC-45A mRNA and protein expression elevated in human cell lines derived from breast carcinoma metastases. UNC-45A knockdowns decreased breast cancer cells proliferation and invasion rates. We also indicated that UNC-45A(a) existed as two isoforms – UNC-45A(a) 929 and 944 – in mammalian cells. …
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Identification of gene expression changes in human cancer using bioinformatic approaches
The human genome contains tens of thousands of gene loci which code for an even greater number of protein and RNA products. The highly complex temporal and spatial expression of these genes makes possible all the biological processes of life. Altered gene expression by mutation or deregulation is …
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Investigating PLEKHS1 adaptor function in PI3K signalling and human cancer biology
… primary driver of oncogenic PI3K activation in cancerous, PTEN-null mouse prostate. PTEN phosphatase is a tumour-suppressor and inactivated commonly in prostate cancers. PLEKHS1 is otherwise a poorly characterised protein. This thesis presents research investigating the relevance and mechanisms …
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