Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"human brain development"”.
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Structure-function relationships in human brain development
The integration of anatomical, functional, and developmental approaches in cognitive neuroscience is essential for generating mechanistic explanations of brain function. In this thesis, I first establish a proof-of-principle that neuroanatomical connectivity, as measured with diffusion weighted …
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Exploring the role of autophagy in shaping human brain development
Contains fulltext : 322721.pdf (Publisher’s version ) (Open Access)
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INVESTIGATING THE ROLE OF FEZ1 IN EARLY HUMAN BRAIN DEVELOPMENT USING CEREBRAL ORGANOIDS
… generated from progenitors during early cortical development contribute to neuropsychiatric disorders. Genetic interventions are known to cause these disorders but underlying mechanism remains unclear. Human FEZ1 gene is associated with a few mental diseases. In this thesis, we seek to determine …
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Functional genomics studies of human brain development and implications for autism spectrum disorder
Human neurodevelopment requires the coordinated expression of thousands of genes, exquisitely regulated in both spatial and temporal dimensions, to achieve the proper specialization and inter-connectivity of brain regions. Consequently, the dysregulation of complex gene networks in the developing …
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MICROGLIA-SUFFICIENT BRAIN ORGANOID
Embryonic primitive macrophages colonize the brain where they differentiate into microglia. Microglia were shown to contribute to brain development in animal models but their roles in human brain development remain poorly understood due to the lack of tissue access. The generation of brain …
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Modelling Prenatal Hypoxia As A Risk Factor For Schizophrenia Vulnerability In Patient-Derived Cerebral Organoids
Prenatal hypoxia during fetal development is a significant environmental risk factor linked to schizophrenia (SCZ) vulnerability. However, hypoxia’s impact on human brain development at the cellular level remains unclear. Our laboratory has developed human cerebral organoids using induced …
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THE INTERPLAY BETWEEN ENDOCRINE DISRUPTION AND GENETICS IN THE PHYSIOPATHOLOGY OF HUMAN NEURODEVELOPMENT: BRIDGING EPIDEMIOLOGY TO MOLECULAR INSIGHTS THROUGH BRAIN ORGANOIDS AND HIGH RESOLUTION OMIC MODELLING
… pre- and postnatal exposure to EDCs and impaired development of cognitive functions, attention and social behaviors in children. Nonetheless, the molecular mechanisms underlying such outcomes are yet to be detailed and EDC-induced DNT (developmental neurotoxicity) remains largely uncovered by the …
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Mummy regulates slit-robo signaling to mediate axon guidance in drosophila embryonic nerve cord
During human brain development, precise connections have to be established to maintain the structural and functional integrity of the nervous system. Mutations in axon guidance molecules have been reported to cause various human nervous system disorders. The Slit-Robo signaling pathway is a …
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Development Of Human Brain Network Architecture Underlying Executive Function
… to adulthood is characterized by refinements in brain structure and function that support the dynamic control of attention and goal-directed behavior. One broad domain of cognition that undergoes particularly protracted development is executive function, which encompasses diverse cognitive …
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Nervonic Acid-enriched Structured Lipids: Preparation, Encapsulation, Digestion and Storage Stability
… vital nutrient that plays a significant role in human brain development and maintenance. However, NA has very poor bioavailability in its free fatty acid (FFA) form. By incorporating NA into the phospholipid (PL) structure, the functionality of NA can be enhanced due to the superior …
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Single cell transcriptomic analysis of autism associated gene expression in human cerebral cortex development
Autism spectrum disorder (ASD) is a range of developmental brain disorders characterized by poor nonverbal communication skills, impaired behaviour and social interaction, and a limited diversity of social activities and interests. As the most common pervasive developmental disorder, it affects …
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Thyroid hormone action and disruption in the brain: Xenopus as a model to study disruption of thyroid hormone availability on early brain development
Thyroid hormones (TH) are essential for normal brain development in vertebrates. Disruption of TH action, either due to genetic and/or environmental factors, has been implicated in neurological defects such as autism, attention deficit hyperactivity disorders (ADHD) and IQ loss. On average, over 30 …
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ADULT HUMAN BRAIN MENINGES HOST NEURAL STEM/PRECURSOR CELLS THAT CAN BE IN VITRO EXPANDED AND SHOW MULTIPOTENT NEURAL DIFFERENTIATION POTENTIAL IN 2D AND 3D CULTURE
During brain and spinal cord development majority of the cell types are produced by the multipotent, self-renewing and proliferating neural stem/progenitor cells (NSCs) through the processes like neurogenesis and gliogenesis [1]. In the developed mammalian brain these NSCs have been found to be …
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A Reductionist Approach to Modeling Human Corticogenesis
… of the molecular and cellular basis of cortical development comes largely from mouse studies due to the genetic tractability of this model system. However, as primate studies have shown, the primate brain is unique in terms of its progenitor and neuronal composition, cortical areas, scale, and …