Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"human aortic endothelial cells"”.
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Endothelial cell plasticity as a marker of vascular disease and predictor of adverse outcomes to stress
Endothelial cells (ECs) dynamically sense and adapt to their local biomechanical and biochemical environments, a process crucial for maintaining vascular homeostasis. Loss of this plasticity is implicated in vascular diseases, where endothelial dysfunction and maladaptive responses exacerbate …
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The effect of metformin on vascular function and AMP-activated protein kinase activation in Type 2 diabetes
… association between obesity, insulin resistance, endothelial dysfunction and accelerated atherosclerosis, but the molecular mechanisms underlying this link are incompletely understood. Biguanides and thiazolidinediones are widely used in the treatment of Type 2 diabetes to improve glycaemia but …
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Investigating the Role of Phosphodiesterase 1C in Vascular Smooth Muscle Cell Migration and Invasion
Phenotypic plasticity of human arterial smooth muscle cells (HASMCs) allows them to transition from a “contractile/quiescent” state, in which they regulate arterial tone and blood pressure, to one in which these cells are more “synthetic/activated”. Synthetic/activated HASMCs are migratory and …
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Plasma membrane calcium ATPase 4 (PMCA4) and inflammation of the aortic endothelium
… the circulation to sites of tissue injury. The endothelial expression of cell adhesion molecules, namely the selectin family, mediates the initial adhesive interactions between leukocytes and the endothelium. Immune cell infiltration is often involved in the initiation and progression of several …
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Divergent regulation of zinc metallopeptidases by shear stress in macrovascular endothelial cells via an NADPH oxidase - superoxide pathway
… the vascular endothelium, causing realignment of endothelial cells in the direction of flow and strengthening of intercellular tight junction barriers. Conversely, disturbed shear stress (DSS), a contributing factor to vascular diseases such as atherosclerosis and coronary artery disease, prevents …
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Role of Sodium Arsenite in Atherogenesis
… protein kinase C (PKC) isotypes, α and β, in human aortic endothelial cells (HAECs) and (3) determining the effects of activation of PKC isotypes, α and β, on the endothelial barrier. Accordingly, exposure of ApoE-/- /LDLr-/- mice to As(III) in drinking water showed an increasing trend in …
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Role of Sodium Arsenite in Atherogenesis
… protein kinase C (PKC) isotypes, α and β, in human aortic endothelial cells (HAECs) and (3) determining the effects of activation of PKC isotypes, α and β, on the endothelial barrier. Accordingly, exposure of ApoE-/- /LDLr-/- mice to As(III) in drinking water showed an increasing trend in …
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Metabolic regulation of human vascular endothelial cell function in vitro
… such as endothelin-1 and thromboxane A2. Endothelial NO is the principal vasodilator in the vasculature and is produced by endothelial nitric oxide synthase (eNOS). Insulin is a vasoactive hormone that exerts its vasodilatory effects through eNOS-mediated NO production. Endothelial …
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Mechanisms of soy isoflavones in the regulation of vascular function
… the effect of genistein on the expression of endothelial nitric oxide synthase (eNOS) both in vitro and in vivo; (2) to define the mechanism by which genistein regulates eNOS expression; and, (3) to examine whether genistein protects against tumor necrosis factor-alpha (TNF-α)-induced …
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18F-markierte S100-Proteine als potentielle Radioliganden für die funktionelle Charakterisierung des Rezeptors für advanced glycation endproducts (RAGE) in vitro und in vivo
Die Interaktion von S100-Proteinen mit dem Rezeptor für advanced glycation endproducts (RAGE) wird als hoch relevant bei der Entstehung, Manifestation und Progression verschiedener entzündlicher Erkrankungen sowie bei der Tumorigenese gewertet. Das tiefergehende Verständnis der Interaktion von …