Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"human TBI"”.
-
Translational Studies of Acute and Chronic Traumatic Brain Injury: Molecular Profiling of Tissue and Biofluids
Traumatic brain injury (TBI) is a leading contributor to the global burden of disease. Despite the growing awareness of TBI and years of research into biomechanics and pathophysiologic mechanisms, there is still a lack of effective therapies to treat patients. To better understand the genomic …
-
Therapeutic Effects of Human Mesenchymal Stem Cells on Traumatic Brain Injury in Rats: Secretion of Neurotrophic Factors and Inhibition of Apoptosis
Traumatic brain injury (TBI) leads to secondary brain insults, which often result in permanent functional loss of damaged cells. Many researchers have looked for methods that will reduce secondary brain damage since there is no effective therapeutics to recover functional loss of damaged tissues. …
-
The Role of STING-Mediated Neuroinflammation in Traumatic Brain Injury
… available for traumatic brain injuries (TBI). Neuroinflammation is a key aspect of the secondary injury process, but remains poorly understood. Recent work has shown that Type I Interferons, inflammatory cytokines typically produced in response to viral infection, are present in the …
-
Applications of blood biomarkers of traumatic brain injury across the severity spectrum---a focus on pathophysiological mechanisms
INTRODUCTION. Traumatic Brain Injury (TBI) is a global health concern. Spanning mild cognitive disturbances to unsurvivable trauma, the clinical challenges of TBI range from acute life-saving predicaments to the management of chronic cognitive impairment. While the primary insult leading to injury …
-
Comparison of progression of diffuse axonal injury with histology and diffusion tensor imaging
… has been reported to be sensitive to TAI in human TBI patients by measuring water molecular diffusion motion in white matter fiber tracts. To date, only one correlative animal study has been carried out to investigate the DTI relationship to TAI, and it has reported a relationship between DTI …
-
Mechanisms of Cerebral Autoregulation in Traumatic Brain Injury
… injury process in traumatic brain injury (TBI), there are still unknowns before we can target autoregulatory disturbance in the neurocritical care unit. This thesis addresses two aspects of these unknowns: 1) CA in the previously uncharacterised paediatric TBI (pTBI) population, and 2) the …