Global ETD Search
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Showing 1 to 9 of 9 for “"human T-cell leukemia virus"”.
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Characterization of Human T-Cell Leukemia Virus 1 Reverse Transcriptase
<p>Human T-cell leukemia virus 1 (HTLV-1) is a type C human retrovirus which has been the causative agent of Adult T-cell leukemia. Replication of the retrovirus; requires a reverse transcriptase which converts the retroviral RNA into DNA which is later incorporated into the host's genome. Very …
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Regulation of Human T-cell Leukemia Virus Type 1 Infection and Replication
Retroviruses have evolved complex mechanisms to regulate their cellular tropism and gene expression. It is generally accepted that productive infections proceed via interactions between viral envelope molecules and specific receptors on the host cell surface. Currently, there is no known receptor …
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Subcellular Localization of Human T-cell Leukemia Virus Type 1 Tax Oncoprotein
<p>Human T-cell Leukemia Virus Type 1 (HTLV-1) is a transforming retrovirus that gives rise to Adult T-cell Leukemia (ATL) and a variety of other subneoplastic conditions such as HTLV-Associated Myelopathy/Tropical Spastic Paraperesis (HAM/TSP). In ATL, the transformation and immortalization of …
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Isolation and Functional Mapping of Human T-Cell Leukemia Virus Type 1 Tax Oncoprotein DNA-Damage Complexes
<p>Human T-cell Leukemia Virus Type 1 (HTLV-1) is a transforming retrovirus which causes Adult T-cell Leukemia (ATL) and HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). Cellular transformation can be caused by a single viral <em>trans</em>-activating protein, Tax. Tax may …
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Heterotrimeric coiled-coils as viral fusion protein mimics
… to the electrostatic interface. Many enveloped viruses, including HIV-1, incorporate trimeric coiled-coils in their fusion proteins, and, consequently, are involved in the pathway to infection. Through interactions at the electrostatic interfaces of the coiled-coils, these fusion proteins form a …
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Study of the DNA Damage Complexes Within the HTLV-1 Tax Oncoprotein Interactome
<p>Human T-cell leukemia virus type 1 (HTLV-1) is a transforming retrovirus that can give rise to adult T-cell leukemia (ATL) and HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). Tax is a virally encoded oncoprotein that is involved in HTLV-1 mediated cellular transformation. It …
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Mutational analysis of the human histone chaperone, Nap1, in nucleosome disassembly at the HTLV-1 promoter
The human genome is packaged to fit within the confines of the nucleus through the interaction with four core histone proteins, H2A, H2B, H3 and H4. These proteins organize the genetic material, however they also make it difficult for the cells to access the information stored within the DNA …
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HTLV-1 bZIP FACTOR ACTIVATES MYOFERLIN EXPRESSION TO FACILITATE HTLV-1 INFECTION AND MIGRATION OF INFECTED T-CELLS
Human T-cell Leukemia Virus type 1 (HTLV-1) is a complex retrovirus responsible for diseases such as Adult T-cell Leukemia (ATL) and HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). The viral protein HBZ is consistently expressed in infected individuals and plays a crucial role …