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Showing 1 to 3 of 3 for “"human PGC"”.
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Signalling and transcriptional regulation of human primordial germ cell specification
Primordial germ cells (PGCs), the precursors of gametes, are specified in early post-implantation human embryos, which are inaccessible for direct investigation. This process can however be modelled using human embryonic stem cells (hESCs) for in vitro derivation of human PGC-like cells (hPGCLCs). …
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Genesis of the human germline
… this thesis was to examine the specification of human primordial germ cells (PGCs) and the mechanism regulating the transient gain and loss of competence for germ cell fate. Specification of PGCs in humans occurs during weeks 2 to 3 in gastrulating embryos, which eventually develop into sperm and …
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A Translational Approach to Modeling Unique Aspects of Germ Cell Development During Self-Organization of the Primate Embryo
… work has demonstrated that several aspects of human primordial germ cell (hPGC) development are specific to primates, necessitating model systems and in vivo validation that is also species specific. In this work, a synthesis of in vitro and in vivo techniques is used to investigate hPGC …