Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"hspb1"”.
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The sHsp expression signature in the brain and modulation in models of chronic neurodegeneration
… expression pattern for HspB5 (?Bcrystallin).<br/>HspB1 (Hsp25) and HspB8 (Hsp22) demonstrated overlapping expression in the<br/>lateral and dorsal ventricles of the brain, as well as expression in a distinct set of motor<br/>neurons in the ventral horn of the spinal cord. Further, cellular …
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Protein-Protein Interactions in Cell Cycle Proteins: An <i>In silico</i> Investigation of Two Important Players
… and (2) Heat Shock Factor Binding Protein 1 (HSPB1). Our findings place both NEK10 – MAP3K1 and NEK10 – HSPB1 interactions in the context of ciliogenesis and provide valuable insights into the underlying mechanism and functional significance of NEK10 in human ciliopathies and cancer, laying …
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Disease-modifying effects of human small heat shock proteins in zebrafish models of neurodegeneration
… zebrafish tauopathy models. Of all eleven sHSPs, HSPB1, B4 and B5 ameliorated morphological disease phenotypes induced by pan-neuronal expression of mutant A152T tau. HSPB4 and B5 have never been demonstrated to be beneficial in a tauopathy model in vivo, and peptides created from the central …
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Dysregulated Apoptosis in Teratogen-Induced Neural Tube Defects in Mice
… stimulation normalized the expression of Fn1 and Hspb1 and thus may mediate protection through these signaling pathways. In tap water exposed embryos, no change in apoptotic pattern was observed by flow cytometry, TUNEL assay and RT-PCR. Also, none of the signal transduction pathway genes tested …