Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"hox genes"”.
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Patterning of the posterior neurectoderm by labial-like Hox genes and retinoids
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1997.
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Dynamic histone modifications at the promoters of Hox genes in embryonic stem cells
… Here, the link between histone modifications and Hoxb gene expression in mouse embryonic stem (ES) cells was explored. Levels of the “active” modifications H3K9ac and H3K4me3 at Hoxb promoters varied widely from gene to gene, but were closely correlated in ES cells. Contrastingly, the repressive …
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CONTRIBUTIONS OF THE 3' HOX GENES, HOXA1, HOXB1, AND HOXB2, TO PATTERNING OF THE AXIAL SKELETON DURING DEVELOPMENT
To investigate whether Hoxb1, as well as related proteins Hoxa1 and Hoxb2, are involved in vertebral development, we analyzed the skeletons of 18.5dpc Hoxa1, Hoxb1, and Hoxb2 loss-of-function single and double mutant embryos. Our analysis reveals that loss of Hoxb1 and Hoxb2 function leads to …
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Development of leg motor neurons in drosophila melanogaster
… candidate gene approach. In vertebrate systems, Hox genes and Hox cofactors regulate spinal cord motor neuron identity. Although much work has been done addressing the function of Hox genes and Hox cofactors in vertebrate motor neuron development, the function of Hox genes and Hox cofactors in …
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An evolutionary perspective on the sequence, mechanism, and regulatory function of animal microRNAs
… at three paralogous loci in the mammalian Hox clusters, and has complementarity to messages of several Hox genes, including Hox8 paralogues. RNA fragments diagnostic of miR-196-directed cleavage of Hoxb8 were detected in mouse embryos. Cell culture experiments demonstrated down-regulation …
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E2F6 in axial skeletal development and gliosis
… and participates in PcG-mediated repression of Hox genes. Hox genes are required for correct patterning of the mammalian skeleton. Loss of E2f6 results in posterior axial skeletal transformations. Mice deficient for both E2f6 and Bmil, a component of PRC1, exhibit increased penetrance of axial …
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A novel computational method for inferring dynamic genetic regulatory trajectories
… In particular, the trajectories taken by the Hox genes through the space of regulatory states are characterized. Understanding the dynamics of Hox regulation is important because the Hox genes play a fundamental role in the establishment of motor neuron sub-type identity during development [6].
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Genetic and Epigenetic Interactions in in vivo and in vitro Reprogramming
<p>In cancer pathogenesis and induced pluripotent stem: iPS) cell production, an essential step for reprogramming is acquisition of self-renewal. In hematopoietic cells, HOX genes are partially responsible for self-renewal, and HOX gene dysregulation commonly occurs in acute myeloid leukemia: AML). …
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Cell Fate Determination Along The Anterior-Posterior Axis In The Mud Snail Ilyanassa obsoleta.
… axis. I chose to look at the expression of the Hox genes, a highly conserved family of genes involved in axial patterning within bilateral organisms. I cloned 11 Hox genes fragments from the gastropod Ilyanassa obsoleta and compared the Ilyanassa sequences to the released genomes of Capitella …
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MicroRNA targeting in mus musculus and Caenorhabditis elegans
… number equivalent to 1-2% of the protein-coding genes. With the exception of plants, miRNAs most commonly regulate targets by imperfectly pairing to 3' untranslated regions (UTRs), leading to translational repression or mRNA destabilization. The microRNA miR-196 is encoded at three paralogous …
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New roles for Hox and Wnt in Cell Migration
… below I report new roles for established genes such as Wnt and Hox, and describe roles for several new genes in neuron migration. To study migrating neurons I use the model organism nematode worm Caenorhabditis elegans. With only 302 neurons, C. elegans is an excellent model to examine …
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KEY DEVELOPMENTAL EVENTS IN THE ORIBATID MITE, ARCHEGOZETES LONGISETOSUS, AND THE EVOLUTION OF CHELICERATE BODY PLANS.
… shown that a conserved suite of developmental genes pattern the chelicerate body plan, with slight modifications in their expression patterns correlating with morphological diversification and evolution of segments and the appendages that they bear. Although a few tractable evo devo chelicerate …
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Generation of A L. Hesperus embryonic cDNA library for the isolation of genes involved in early pattern formation
… other metazoans primarily use two families of genes called Hox genes and Pax genes to regulate embryogenesis. Because of the high evolutionary conservation of Hox and Pax proteins, I hypothesize that arachnids also use this system to organize their body pattern. To enable studies of the Westem …
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Investigating the roles of candidate gap genes from the neuroblast timer series during axial patterning in the beetle Tribolium
The gap genes encode transcription factors that play a central role in the process of segment patterning in Drosophila. Specifically, they interact to form the well-characterised ‘gap gene network’, which directs the formation of segment boundaries (through regulation of pair-rule genes), and the …
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Molecular phylogenetics of the Metazoan clade Lophotrochozoa
… to lophotrochozoans. Chapter 4 investigates the Hox gene complement of the bryozoan Bugula turrita. Six Hox genes were recovered, including an ortholog of the posterior class gene Post2, which is a synapomorphy for the Lophotrochozoa. The identification of a Post2 ortholog provides evidence of a …
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Characterising the function and evolution of enhancers in Drosophila
… the spatial and temporal expression of most genes. Therefore understanding how enhancers work and evolve is crucial for understanding the regulation of most developmental processes in animals. In my PhD project, I investigated three important aspects of enhancers to further our understanding …
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The Effects of Mutations in Hoxa13a, Hoxa13b, and hHoxd13a on the Zebrafish Fins
… question in evolutionary biology, although hox gene expression patterns could play a prominent role in this evolutionary event. Hox genes encode transcription factors that are important for patterning during development. Specifically, the hox13 genes have been shown to be essential for …
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Unraveling The Molecular Mechanisms Of Insect Diversity
… limbless abdomen via the up-regulation of the hox gene abdominal-A (abd-A) in the milkweed bug (Oncopeltus fasciatus) that is not present in Drosophila. Hence, these data indicate that there are at least two independent mechanisms that act to maintain the establishment of the limbless abdomen …
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Damaged Collagen Detection and A Novel Approach to 1,3-Dipolar Cycloaddition Reactivity: Research at the Interface of Chemistry and Biology
… assist in clinical decision-making. Chapter 5: Hox genes maintain critical roles in the adult skeleton. Recently, it has been demonstrated that Hox expression continues from embryonic stages through postnatal and adult stages exclusively in a skeletal stem cell population. However, whether Hox …
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Analysis of HOXA5 expression and function in development of the central nervous system
<p>The Hox genes encode transcription factors that are indispensable for proper spatio-temporal patterning of the vertebrate body axes. In mouse, Hoxa5 transcripts are differentially expressed in specific mesoderm-derived structures and in the most anterior domain of expression in the central …
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