Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"house dust mite"”.
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Genomic and Proteomic Characterisation of the European House Dust Mite, Dermatophagoides pteronyssinus
House dust mites are major causative agents in the pathogenesis of allergy. Their proximity with human habitats, association with development of allergenic diseases, and resistance to physical and chemical control measures; make them some of the most medically important mites. Understanding of …
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Determining the Effects and Signaling Properties of β-Blockers in House Dust Mite-Driven Murine Models of Asthma
… models of asthma using the allergens from house dust mites (HDM). To further increase the clinical relevance of our present studies, we designed protocols to study the ‘prophylactic’ and ‘therapeutic’ effects of β-blockers by initiating drug treatment pre- and post- the development of …
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IgE-reactivity and proinflammatory cytokine -inducibility of various recombinant house dust mite allergens including novel rDer f 4
House dust mite (HDM) is the most important inducer of allergy and asthma in the world. More than thirty three group of mite allergens have been reported from HDMs and storage mites (SMs). The accurate diagnosis of mite allergy is a very important for effective treatment. For diagnosis and …
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The effect of domestic mechanical heat recovery ventilation on asthma control of patients allergic to the house dust mite
… humid environment favours the growth of the house dust mite population. Allergy to the house dust mite is the most common allergy associated with asthma in the UK. Studies of occupational asthma, seasonal asthma and at altitude infer that the environment may directly affect symptoms of …
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A systematic review of treatments for atopic dermatitis
… and oral cyclosporin. Treatments that show limited evidence of a benefit include non-sedatory antihistamines, topical doxepin, the oral antibiotic Cefadroxil on clinically infected AD, the topical antibacterial Mupirocin on clinically uninfected AD, Chinese herbs, hypnotherapy and biofeedback, …
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Remodeling of the pulmonary circulation - a novel response to allergic airway inflammation
… inflammation (where chicken egg albumin (OVA) or house dust mite (HDM) extract were used as allergens). More specifically the structural alterations of remodeling, the time frame of development and the resolution were investigated. The studies show that vascular remodeling is a feature of allergic …
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Immunomodulatory effect of the Acanthocheilonema viteae product ES-62 in arthropod extract models of asthma
… has been found to alleviate inflammation in a house dust mite extract (HDME) allergy model.;The intention of this study was to identify whether ES-62 inhibits the induction of allergy in cockroach extract (CRE) and HDME models through the analysis of several key parameters of allergy induction. …
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Respiratory allergy and asthma associated with pesticide exposure amongst women in rural Western Cape
… atopy and quantification of specific IgE to house dust mite, storage mite and spider mite). The outcome variables included doctor diagnosed asthma, adult onset asthma, current asthma, allergic sensitisation, allergic airway inflammation and the asthma symptom score. The asthma symptom score …
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Sensory Neurons Initiate Tuft Cell-Dependent Sinonasal Allergic Inflammation via Substance P
… the impact of intranasal administration of house dust mite or fungal allergens on these cells and sought to understand the mechanisms underpinning the allergic response. We observed that these allergens incited a significant expansion in tuft cells, eosinophilia, sneezing, Type 2 immune …
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Vaikų autizmo, alergijų ir elgesio modelių sąveikos tyrimas /
… – milk, hazelnut and peanuts; inhalant: house dust mite, birch, cat dander and dog fur. In the study, a statistically significant association was also observed between attention deficit/hyperactivity disorder (ADHD) and allergies – the majority of allergic children with ASD had this …
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Investigating role of IL-4 receptor alpha (IL-4Ra) in murine models of atopic dermatitis
… during AD. We investigated 3 models of AD using House dust mite (HDM), Ovalbumin (OVA) and low-calcemic analog of vitamin D (MC903) on mouse strains lacking IL-4Ra on various B and T cells. We used mb1creIL-4Rα-/lox (mice lacking IL-4Rα on B cells), iLcKCre IL-4Rα-/lox (mice lacking IL-4Rα on all …
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Allergen-induced change in airway responsiveness to direct and indirect stimuli in mild atopic asthmatics
… to allergen extracts such as cat, horse, and house dust mite completed the 3-hour study. Eleven mild atopic asthmatics with the criteria above completed the 24-hour study. Both studies were non-blinded, randomized clinical trials. Airway responsiveness to MCh was quantitated by changes in …
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The effect of parasite antigen on experimentally induced ‘asthma’ in lambs
… inoculation of an asthma-causing allergen [house dust mite (HDM) - Dermatophagoides pteronyssinus] or helminth antigen [Trichostrongylus colubriformis L₃ (TCL₃)] on the development of experimentally induced ‘asthma’ in sheep. Feti or neonates of twin-bearing ewes (n=22) were treated with …
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The temporal requirement of IL-4Rα signalling in allergic asthma and the role of IL-4Rα-responsive Regulatory T cells in restraining allergic airway inflammation
… and inflammation in allergic asthma, have had limited success. Therefore, we aimed to investigate the function of IL-4/IL-13 responsive regulatory T cells in a TH2 rich environment and the temporal requirement of IL-4Rα-signalling in asymptomatic and acute airway disease. Objective 1: We …
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Implicación de igf1r en inflamación pulmonar aguda y en alergia inducida por ácaros del polvo doméstico en ratones
… CreERT2 mice were intranasally challenged with house dust mite (HDM) five days per week for four weeks to study the implication of IGF1R in chronic asthma pathobiology. On the other hand, inbred C57BL/6 and CreERT2 mice were given daily consecutive doses of HDM extract to study the acute …
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BMPR2 and mTOR Signaling Pathways in Inflammatory Lung Diseases
… BMPR2 mutant mice were exposed to the allergen, house dust mite (HDM), for 7 or 20 weeks. Our studies showed similar increases in pulmonary arterial pressures and vascular remodeling in wild-type and BMPR2 mutant mice compared to controls. These data suggest that increases in pulmonary arterial …
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Analysis of Immunomodulatory Effects of Vitamin D in Epithelial-Mesenchymal Transition and Airway Remodeling in Allergic Airway Inflammation.
… a combination of clinically relevant allergens house dust mite, ragweed, and Alternaria alternata (HRA), and fed a special vitamin D-sufficient or vitamin D-supplemented diet. HRA-vitamin D-supplemented mice had increased pulmonary function, as measured by airway hyperresponsiveness, increased …
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Intrinsic alterations of the skin barrier function promote the pathogenesis of atopic dermatitis in dogs
… response to common environmental stimuli such as house dust mites. Based on such hypotheses we isolated canine keratinocytes from healthy and atopic dogs and exposed them to several immunological stimuli (cytokines, bacterial antigens, house dust mite extract, and vitamin D3) to mimic the milieu …
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The role of Interleukin-4 induced gene 1 (IL-4i1) in allergic asthma and atopic dermatitis
… asthma, a high dose (100µg/per mouse) of house dust mite (HDM) was used in sensitizing mice intratracheally at day 0 and challenged at day 7 to 11 intranasally under anaesthesia. To assess the development of asthma features, we measured lung function on day 14 and collected blood for …
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Mechanisms Mediating Asthma Tolerance Induced By Regulatory Dendritic Cells Through CD4+CD25+Foxp3+ T Regulatory Cells
… assays. In parallel cultures OVA-, but not house dust mite (HDM)-, presenting DC10 induced ≈43% of CFSE-labeled CD25-/loFoxp3- Teff cells from asthmatic OVA-TCR transgenic mice to redifferentiate into Treg. We recapitulated this in vivo using OVA-asthmatic mice that were co-injected with …
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