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Showing 1 to 20 of 88 for “"hot melt"”.
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Hot-melt extrusion: A versatile pharmaceutical technology
Hot-melt extrusion (HME) is a promising technology for the production of new chemical entities in the developmental pipeline and for improving products already on the market. The first objective of this research work was to describe a continuous process for the production of solid lipid …
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Novel Applications of Hot-Melt Extrusion Technology
Hot-melt extrusion, an adaptable technology, has established its position in a wide spectrum of manufacturing operations like amorphous solid dispersions, immediate and controlled oral formulations, implants, and taste masked products. In recent years the industrial focus has shifted towards …
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Patient Friendly Formulations Utilizing Hot Melt Extrusion Technology
This research work exhibited the new outlook of hot melt extrusion technology for orally disintegrating tablet, fast disintegration films and fixed dose combinations. Previous research demonstrated these applications by conventional formulation techniques which has inherent shortcoming of use of …
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Versatility of hot-melt extrusion for dosage form design
Recently, Hot Melt Extrusion (HME) has attracted the attention of pharmaceutical companies and scientists as a technique for manufacturing a variety of dosage forms. In this research, HME was applied in different ways to achieve different goals, such as solubility enhancement, taste masking, solid …
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Design and evaluation of hot melt extruded transdermal patches.
… to deliver the drug across the skin. The use of hot melt extrusion technology (HME) to prepare these TDDS is also generating considerable interest in the pharmaceutical field. This work combines these interests through preparation of several hot melt extruded formulations screened for their …
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Precision hot-melt freeform 3D printing for monolithic multilayer microfluidics
Miniaturization and integration of assays, chemical synthesis, and cell culture models onto microfluidic chips is an intensive area of research. Despite the diversity of these applications, the vast majority of microfluidic devices are fabricated from polydimethylsiloxane (PDMS) using the same …
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Physicochemical characterization of solid dispersions prepared using hot-melt extrusion technology
… the physicochemical properties of the prepared melt extrudates by different analytical techniques. Hot melt extruded solid dispersions of BL were prepared using polyethylene oxide (PEO) or polyvinylpyrrolidone (PVP) as hydrophilic carriers, whereas PVP or Eudragit 4155F was used to prepare the …
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The kinetics of drug dissolution in polymers during hot-melt extrusion
… for the water-soluble drugs. In pharmaceutical Hot-melt extrusion poorly water soluble drug particulates are mixed with water soluble polymer excipient particulates and fed in the extruder, where the polymer is melted, after which the drug particulates begin to dissolve into the polymer melt. …
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Hot-melt mixing of partially miscible active pharmaceutical ingredient-polymer mixtures
… producing pharmaceutical oral dosages such as hot-met extrusion (HME) have received increasing attention by industry and academe because they can enhance drugs' solubility and even bioavailability to a great extent by converting drugs from crystalline to amorphous form. HME can be carried out …
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Dispersion and dissolution kinetics of API particles in pharmaceutical hot melt extrusion
Pharmaceutical Hot Melt Extrusion (HME) is essentially a special case of polymer compounding. The elementary steps involved in traditional plastics melt processing are handling of particulates, melting, dispersive and distributive mixing, devolatilization and stripping, and finally pressurization …
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Foaming of amorphous drug delivery systems prepared by hot melt mixing and extrusion
… Ingredient (API) and Polymer excipient. The Hot Melt Extrusion (HME) process is used to compound the following API / polymer binary systems: Indomethacin (INM) with Soluplus (PVCap-PVAc-PEG); Carbamazepine (CBZ) with PVCap-PVAc-PEG; and INM with Eudragit EPO. Comprehensive characterization of …
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Development and Characterization of Sustained-Release Formulations via Novel Hot Melt Extrusion Techniques
Hot melt extrusion (HME) is a leading technology that can be applied to many pharmaceutical preparations as solid dispersions. Part of this research project focus on injecting pressurized carbon dioxide (P-CO2) gas during the HME process. These combined techniques have an additional advantage of …
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Characterization of different hydrophilic polymers and their applicability in hot melt extrusion technology
… necessary to utilize a novel technology such as hot melt extrusion (HME) in combination with hydrophilic polymers to obtain tailored drug release. Over recent years HME technology has found widespread application as a viable drug delivery option in the drug development process. Some of the HME …
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Crystalline Salt Formation of an Acidic Drug Indomethacin Using Hot Melt Extrusion Technology
… water-soluble drug) can be increased by using hot melt extrusion of a 1:1 (mol/mol) indomethacin:tromethamine mixture to form a highly crystalline salt, the physicochemical properties of which are investigated in detail. Specifically, pH–solubility studies demonstrated that this salt exhibited …
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Preparation And Evaluation Of Valacyclovir Hydrochloride Ocular Inserts By Hot Melt Extrusion Technique
… study was to investigate the processability of Hot Melt Extrusion to formulate Ocular Inserts of Valacyclovir Hydrochloride and Evaluate its drug release in vitro and in vivo. Valacyclovir is the prodrug of Acyclovir, which is used in treatment of ocular keratitis and HSV infections. The …
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Assessment of a marine polysaccharide for use as excipient in pharmaceutical hot-melt extrusion
Pharmaceutical Hot Melt Extrusion (HME) is currently investigated by both industry and academia as a method for manufacturing solid oral dosages with improved bioavailability of poorly-water soluble active pharmaceutical ingredients (APIs) and control drug release of water-soluble APIs. Although …
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Influence of hot melt extrusion processing parameters on the properties of a pharmaceutical formulation
Hot melt extrusion (HME) is an old technology that has been recently adapted to be used in the pharmaceutical industry. HME is a continuous process that is widely used to produce a solid dispersion matrix. The aim of this dissertation is to evaluate different factors that will affect the …
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Hot melt extrusion (HME) processing for the development of lipid oral solid dosage forms
This research study explores the use of lipids in hot melt extrusion (HME) for the preparation of sustained release solid lipid matrices. The use of lipids instead of polymers is a novel approach with distinct advantageous. Sustained release solid lipid matrices of diclofenac sodium …
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Nuclear Magnetic Resonance for the Characterisation of Hot-Melt Extruded Pharmaceutical Amorphous Solid Dispersions
… the oral bioavailability of poorly soluble APIs. Hot-melt extrusion (HME) is one method for preparing ASDs that is growing in importance in the pharmaceutical industry. HME involves the combination of an API and a polymer, which are heated and intensively mixed to yield a homogeneous product. …
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Microphase Separation Studies in Styrene-Diene Block Copolymer-based Hot-Melt Pressure- Sensitive Adhesives
… pressure-sensitive adhesive compositions in melt. The work also focuses on determining the microphase separation mechanism in adhesive melts containing various amounts of low molecular weight resin (tackifiers) blended with styrene — diene block copolymers. To understand the correlation …
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