Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"host-virus interactions"”.
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Host-virus interactions in Salmonella O-antigen biosynthesis
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 1967
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Host/virus interactions in the marine cyanobacterium prochlorococcus
Bacterial viruses shape the diversity, metabolic function, and community dynamics of their microbial hosts. As microbes drive many major biogeochemical cycles, viral infection is therefore a phenomenon of global significance. A significant fraction of primary production in the oceans is performed …
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An investigation into BK Polyomavirus and host-virus interactions
… potentially oncogenic human pathogen BK Polyomavirus (BKPyV) was first identified in 1971 and has since been associated with a number of diseases primarily in immunosuppressed patients. Infection is established in early life and by adulthood up to 90% of populations show seroconversion for the …
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DISSECTION OF HOST-VIRUS INTERACTIONS IN THE HUMAN CENTRAL NERVOUS SYSTEM
… despite antiviral treatment. Neurotropic viruses cause viral encephalitis due to their ability to invade the central nervous system (CNS), and the most common cause is HSV-1. Inborn errors of immunity (IEIs) have demonstrated that neuron, cell type-specific, antiviral immunity is essential …
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Cell cycle of Emiliania huxleyi and its effects on host: virus interactions
… and it is regularly forms large blooms. Viruses are an important agent of mortality in blooms, however, little is known about the host:virus interactions in this system. This project investigated how infection at different stages of the host cell cycle influenced: virus adsorption, …
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Viral diversity and host-virus interactions in the model crenarchaeon Sulfolobus islandicus
Viruses are pervasive evolutionary forces and key players shaping natural populations. Our understanding of viral impact on host physiology however, is based on a few model systems that represent a small fraction of the life-history strategies employed by hosts or viruses across the three domains …
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Platforms for exploring host-pathogen interactions in hepatitis C virus infection
… almost 200 million worldwide, hepatitis C virus (HCV) mounts a chronic infection of liver hepatocytes that causes substantial morbidity and mortality. An understanding of host-virus interactions will drive the development of therapeutics, but research is restrained by available experimental …
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Evolutionary History of Immunomodulatory Genes of Giant Viruses
Nucleocytoplasmic large DNA viruses (NCLDVs) have genome sizes that range from around 100 kilobases (kb) to up to 2.5 megabases, and virion sizes that can reach up to 1.5 μm. Their large size in both of these contexts is atypical and defies the traditional view that viruses are streamlined, …
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Interactions of Mammalian Retroviruses with Cellular MicroRNA Biogenesis and Effector Pathways
… pathway has emerged as an important regulator of host-virus interactions. While miRNAs of viral and cellular origin have been demonstrated to modulate viral gene expression and host immune responses, reports detailing these activities in the context of mammalian retroviruses have been …
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KSHV encoded viral processivity factor, ORF59, regulates multiple pathways for viral replication
Kaposi's Sarcoma-Associated Herpesvirus (KSHV), or human herpesvirus 8 (HHV-8), is a tumorigenic herpesvirus tightly linked with various human malignancies including Kaposi's Sarcoma, Primary Effusion Lymphomas (PELs), and Multicentric Castleman's Disease. Immunocompetent individuals infected with …
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Characterization of Host Factors and Anti-viral Compounds for Diverse Mosquito-borne Flaviviruses
… therapeutics requires discovery of novel host-virus interactions as well as an informed anti-viral discovery pipeline. We used a genome-scale RNAi-based screen followed by a chemical screen of FDA-approved therapeutics to identify scores of novel dengue virus (DENV) human host dependency …
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A study of norovirus: molecular epidemiology, pathogenesis and antiviral development
Norovirus (NoV) is one of the most common human pathogens that causes acute gastroenteritis globally. NoVs which belong to a single genotype (of more than 36) namely the Genogroup II, genotype 4 (GII.4), are of particularly importance because they are responsible for ~70% of all NoV infections …
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Identification and Characterization of Novel Caenorhabditis Nematode Viruses
… been broadly considered for investigating host-pathogen interactions. During this time a number of bacterial, fungal, and microsporidial pathogens were shown to infect C. elegans; however, until recently, no natural viruses were known, resulting in a limited understanding of virus-host …
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Proteomic Investigation of Interferon Alpha Stimulation and Viral Regulation to Identify Candidate Antiviral Restriction Factors
Antiviral restriction factors (ARFs) are host proteins that play key roles in inhibiting viral infection. The plasma membrane provides a critical interface between the cell and the virus, meaning that proteins present here are well situated to act as ARFs. An understating of these ARFs and how …
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Vaccinia virus BTB-Kelch proteins
Vaccinia virus (VACV) is a valuable tool to study host-virus interactions and encodes a plethora of immunomodulatory proteins, among which three, A55, C2 and F3, have a BTB/BACK-Kelch (BBK) structure and are the focus of this study. Proteins containing BTB and Kelch domains function as adapters for …
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Activity-Based Protein Profiling Reveals Changes to the Regulation of Enzymatic Activity by the Hepatitis C Virus
… translation, subcellular localisation, co-factor interactions, or chemical modification to specific amino acids. Activity-based protein profiling allows the potential for activity of target enzymes to be measured, thereby gaining a more accurate representation of the functional state of the …
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Persistent viruses in Capsicum annuum plants: Understanding the mystery guests
Most work on plant viruses focuses on their pathogenicity, but recent studies suggest viruses may benefit their hosts, at least under some conditions. Plant-infecting viruses of the Partitiviridae and Endornaviridae are transmitted only vertically, via pollen and seed, generally cause no disease …
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Molecular Mechanisms of Sensing and Synergy by Anti-Bacteriophage Immune Systems in Staphylococcus
<p>Viruses parasitize every known life form on the planet for their propagation and spread. To deal with this constant assault, organisms across all domains of life have evolved immune strategies in the form of genetically encoded systems to defend themselves. Immunity can be conceptualized as …
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Metagenomic analysis of the biodiversity and seasonal variation in the meromictic Antarctic lake, Ace Lake
… of its microbial community, including viruses. Functional potential analyses of the lake taxa highlighted their roles in nutrient cycling. In this thesis, the seasonal changes in Ace Lake microbial community were studied using a time-series of metagenomes utilizing the Cavlab metagenome …