Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 152 for “"host-pathogen interactions"”.
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Host-Pathogen Interactions at the Intestinal Epithelial Barrier
This thesis reports investigations of the interactions between the intestinal epithelial barrier and the intracellular apicomplexan Eimeria spp., both in vivo and in vitro. Initially, conventional in vivo studies using genetically modified animals were used to investigate the contribution of innate …
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Glycans in host-pathogen interactions : an integrated biochemical investigation
… ideal targets for interaction with microbial pathogens. In this thesis, a framework of integrated approaches was developed to characterize the structure-function relationships of host cell surface glycans and examine their role in mediating hostpathogen interactions. The first part of the …
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Host-Pathogen Interactions of Secreted and Surface Staphylococcus Aureus Factors
… aureus is an opportunistic bacterial pathogen that can infect humans and other species. It utilizes an arsenal of virulence factors to cause disease, including secreted and cell wall anchored factors. Secreted toxins attack host cells, and pore-forming toxins destroy target cells by …
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Host-Pathogen Interactions During Leptospirosis in Male C3H/HeJ Mice
… is a zoonotic disease transmitted from reservoir hosts like rodents to other animals and humans, who are incidental hosts. This infection is prevalent in the areas of Southeast Asia, Africa and South America. Inactivated Leptospira serovars vaccines are available in endemic areas but they have …
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Bioelectronic in vitro models for monitoring intestinal host-pathogen interactions
… is a highly complex, dynamic interface where host-microbe interactions not only underpin digestion and immunity but also disease pathogenesis. Studying this in vitro requires models that not only sufficiently recapitulate the physiological complexity of the barrier being investigated but also …
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Using Evolutionary Genomics to Elucidate Parasite Biology and Host-Pathogen Interactions
… may have been acquired from these parasites’ host species. Studies on apicomplexan-specific expanded gene families indicate that kinases are a probable source of functional innovation. The T. gondii kinome displays previously under-appreciated diversity in parasite-specific secreted kinases …
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Development of protein microarrays for the investigation of host-pathogen interactions
Varicella-Zoster virus (VZV) is a human herpesvirus (causing chickenpox and shingles upon reactivation) whose diagnosis is particularly important in pregnancy and immunocompromised patients. Current sérodiagnostic assays are either based on crude whole cell lysates or glycoprotein preparations …
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Bacterial spot of tomato and pepper: insights into host-pathogen interactions
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2023-12-01
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Platforms for exploring host-pathogen interactions in hepatitis C virus infection
… morbidity and mortality. An understanding of host-virus interactions will drive the development of therapeutics, but research is restrained by available experimental tools. Due to the cost and unreliability of existing humanized mouse and primate in vivo models, HCV research is almost …
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Understanding protease-mediated host-pathogen interactions in <i style="">Proteus mirabilis</i>
… mirabilis</i>, a Gram-negative opportunistic pathogen that is primarily implicated in catheter-associated urinary tract infections (CAUTIs), which account for 80 % of all nosocomial infections. ZapA is an important virulence factor that contributes to the evasion of <i>P. mirabilis</i> from …
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Functional Genomic and Image-Based Screening Approaches for Probing Host-Pathogen Interactions
Host-pathogen interactions represent a complex interplay between hosts and pathogens that can evolve over millions of years. Interactions between bacteria or viruses and human cells, and the resulting evolved antipathogenic signaling pathways, are processes responsible for pathologies ranging from …
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Host-pathogen interactions in the innate immune response of the nematode Caenorhabditis elegans
… to investigate the biology of a number of human pathogens. This work continues to uncover mechanisms of host immunity and pathogen virulence that are either analogous to those involved during pathogenesis in alternative animal hosts or mechanisms which are, thus far, unique to the worm. In this …
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Immunomodulatory Effect Of Host And Fungal Eicosanoids During Host-Pathogen Interactions With Candida Albicans
<p>Candida albicans, an opportunistic fungal pathogen, poses a significant clinical threat to immunocompromised patients. Diseases associated with this fungus ranges from superficial mucosal infection to life-threatening systemic candidiasis. The mechanisms by which Candida persists at mucosal …
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Tiny Can Be Big: The Contribution of Microbial Extracellular Vesicles to Host-Pathogen Interactions
The human vagina hosts a microbiome formed by dense numbers of diverse bacterial species which can be categorised based on their species diversity. Despite the variation, the low-diversity communities (i.e. a dominant single species of Lactobacillus) is understood to represent the microbiota of …
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Host-pathogen interactions and conservation implications of snake fungal disease over broad geographical scales
… complete species extinction. Among emerging pathogens, pathogenic fungi have been responsible for drastic declines in several high-profile vertebrate taxa, such as Batrachochytrium dendrobatidis causing chytridiomycosis in many species of amphibians worldwide. Recently, an emerging infectious …
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Understanding Host-Pathogen Interactions of Rift Valley Fever Virus That Contribute to Viral Replication
… are obligate intracellular parasites utilizing host-factors to replicate. This study identified three host-protein interactors of the viral Gn and L proteins that aid in viral replication. UBR4 was determined to be an interactor of Gn via immunoprecipitation followed by either LC/MS/MS or …
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Functional analysis of the role of alternative sigma factors in Vibrio parahaemolyticus host pathogen interactions
… in humans. This organism must adapt to both host and marine environmental stresses. One mechanism bacteria employ to respond to rapid environmental changes is the switching on of specific gene expression patterns through the use of alternative sigma factors. V. parahaemolyticus has 11 sigma …
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Differential Screening in Immunodeficient Mice Reveals Bacterial Enzymes With Unexpected Roles in Host-Pathogen Interactions
<p>Over centuries of co-existence with their hosts, microbes that are exclusively vertebrate pathogens have evolved mechanisms for manipulation of host cells and evasion of the immune system. Some pathogens dodge the immune response by altering the functions of and hiding within the very cells that …
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Early protection against Salmonella infection in chickens by modification of the initial host-pathogen interactions
… opname van de bacterie vanuit de omgeving. De pathogenese van Salmonella in de kip kan worden ingedeeld in 2 fasen : de intestinale en de systemische fase van infectie, die beide gereguleerd worden door genen van verschillende pathogeniciteitseilanden. Salmonella Enteritidis kan de zuurtegraad …
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Identification of the role of the sal locus in streptococcus pyogenes virulence during host-pathogen interactions
<p>The pathogenesis of Streptococcus pyogenes is due to its ability to overcome and adapt to the harsh environment created by the host immune response. The focus of this project was the SalKR two-component regulatory system, which facilitates bacterial adaptation by responding to environmental …
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