Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 255 for “"host-pathogen"”.
-
Systems Biology of Host-Pathogen Protein-Protein Interactions
… an obligate intracellular parasite that co-opts host cellular proteins, often through protein-protein interactions (PPIs), to ensure its replication. Therefore, this thesis aims to integrate high-throughput proteomic approaches with computational modelling to systematically characterize …
-
Host-Pathogen Interactions at the Intestinal Epithelial Barrier
… Additionally, to understand complex epithelial host-pathogen interactions a novel in vitro model of small intestine organoids was developed. Data suggest that immunoprotection against Eimeria vermiformis infections is mediated by T cells. Furthermore, there is an indication that ILCs have a …
-
Evolution of targets at the host-pathogen interface
… and therapeutic options for both the bacterial pathogen Mycobacterium tuberculosis (Mtb) and betacoronaviruses – the Severe Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) in particular – is presented. Chapter 2: Protein-coding potential of the Mtb genome <br>Using comparative genomics, I …
-
Characterization of Bacterial Metabolites Involved in Host Pathogen Resistance
<p>The intestinal microbiome can mediate host resistance to enteric pathogens by modulating host immunity or by directly inhibiting pathogen growth and virulence. Although the abundance and diversity of bacterial metabolites in the intestine is appreciated, the majority of intestinal bacteria and …
-
Glycans in host-pathogen interactions : an integrated biochemical investigation
… ideal targets for interaction with microbial pathogens. In this thesis, a framework of integrated approaches was developed to characterize the structure-function relationships of host cell surface glycans and examine their role in mediating hostpathogen interactions. The first part of the …
-
Host-Pathogen Interactions of Secreted and Surface Staphylococcus Aureus Factors
… aureus is an opportunistic bacterial pathogen that can infect humans and other species. It utilizes an arsenal of virulence factors to cause disease, including secreted and cell wall anchored factors. Secreted toxins attack host cells, and pore-forming toxins destroy target cells by …
-
Host-Pathogen Interactions During Leptospirosis in Male C3H/HeJ Mice
… is a zoonotic disease transmitted from reservoir hosts like rodents to other animals and humans, who are incidental hosts. This infection is prevalent in the areas of Southeast Asia, Africa and South America. Inactivated Leptospira serovars vaccines are available in endemic areas but they have …
-
Creation of Bioinformatics Approaches to Understand Host-Pathogen Molecular Mimicry
… some it is the key to survival. Across phyla, pathogens imitating aspects of their host is crucial to their continued survival and proliferation. Also called molecular mimicry, imitation of host biomolecules has been observed to target a wide range of processes, including host signaling …
-
Bioelectronic in vitro models for monitoring intestinal host-pathogen interactions
… is a highly complex, dynamic interface where host-microbe interactions not only underpin digestion and immunity but also disease pathogenesis. Studying this in vitro requires models that not only sufficiently recapitulate the physiological complexity of the barrier being investigated but also …
-
Chemical Reporters for Investigating Lipidated Proteins at the Host-Pathogen Interface
… such, defects in protein lipidation can render host cells more susceptible to microbial infection and are also associated with a variety of human diseases ranging from cancer to neurological disorders. Moreover, viral and bacterial pathogens can exploit and modulate the host lipidation machinery …
-
Using Evolutionary Genomics to Elucidate Parasite Biology and Host-Pathogen Interactions
… may have been acquired from these parasites’ host species. Studies on apicomplexan-specific expanded gene families indicate that kinases are a probable source of functional innovation. The T. gondii kinome displays previously under-appreciated diversity in parasite-specific secreted kinases …
-
Development of protein microarrays for the investigation of host-pathogen interactions
Varicella-Zoster virus (VZV) is a human herpesvirus (causing chickenpox and shingles upon reactivation) whose diagnosis is particularly important in pregnancy and immunocompromised patients. Current sérodiagnostic assays are either based on crude whole cell lysates or glycoprotein preparations …
-
Bacterial spot of tomato and pepper: insights into host-pathogen interactions
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2023-12-01
-
Identification and characterization of rickettsial proteins at the host-pathogen interface
Bacterial pathogens subvert host cell processes during infection by secreting protein effectors that manipulate host machinery. Cataloging such effectors has enabled a deeper exploration of the molecular basis of disease for numerous pathogens. Members of the Rickettsia genus are obligate …
-
Platforms for exploring host-pathogen interactions in hepatitis C virus infection
… morbidity and mortality. An understanding of host-virus interactions will drive the development of therapeutics, but research is restrained by available experimental tools. Due to the cost and unreliability of existing humanized mouse and primate in vivo models, HCV research is almost …
-
Elucidating the Molecular Function of Reprolysin Metalloproteases in Tick-Host-Pathogen Interaction
<p>Ticks are ectoparasites that attach to their host for many days to weeks, feeding to engorgement and continuing their species life cycle. The mechanisms behind the successful feeding and manipulation of host immune responses have been associated with the secretion of their specialized saliva. …
-
Understanding protease-mediated host-pathogen interactions in <i style="">Proteus mirabilis</i>
… mirabilis</i>, a Gram-negative opportunistic pathogen that is primarily implicated in catheter-associated urinary tract infections (CAUTIs), which account for 80 % of all nosocomial infections. ZapA is an important virulence factor that contributes to the evasion of <i>P. mirabilis</i> from …
-
Functional Genomic and Image-Based Screening Approaches for Probing Host-Pathogen Interactions
Host-pathogen interactions represent a complex interplay between hosts and pathogens that can evolve over millions of years. Interactions between bacteria or viruses and human cells, and the resulting evolved antipathogenic signaling pathways, are processes responsible for pathologies ranging from …
-
Integrative genomic approaches to dissecting host-tumor and host-pathogen immune processes
Two parallel research efforts were pursued. First, we conducted a systematic exploration of how the genomic landscape of cancer shapes and is shaped by anti-tumor immunity. Using large-scale genomic data sets of solid tissue tumor biopsies, we quantified the cytolytic activity of the local immune …
-
Pathosystems Biology: Computational Prediction and Analysis of Host-Pathogen Protein Interaction Networks
… and molecular level, interactions between a pathogen and its host play a vital role in initiating infection and a successful pathogenesis. Despite recent successes in the advancement of the systems biology of model organisms to understand complex diseases, the analysis of infectious diseases …
Page 1 of 13