Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 117 for “"host response"”.
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Host response in sepsis
… characterized by a systemic inflammatory response to an infection. Increased vascular leakage, vasodilation and heart failure cause circulatory disturbances challenging the intensivist. Despite modern medication and high technology supportive care, mortality is high. Key strategies include …
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Virulence potential and host response to Cronobacter sakazakii
… detailed aspects of the virulence potential and host response. Therefore this project compared 34 isolates of C. sakazakii made up of clonal complex 4 (CC4; 21 isolates) and non-clonal complex 4 (13 isolates) strains for their virulence potential, and investigated whether CC4 strains have the …
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The Host Response to Venezuelan Equine Encephalitis Virus
… available. A comprehensive understanding of the host response to a pathogen is integral in the development of both. By using intranasal infection with TC83, the vaccine attenuated strain of VEEV, we are able to mimic VEEV encephalitis as well as evaluate the vaccine candidate. Intranasal …
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Host response to Rift Valley fever virus infection
… limited information has been published on the host response to infection by RVFV. To date, there is little detailed data directly comparing the host response to infection with RVFV and correlation with viral pathogenesis. My goal was to be able to discern the host response to infection and to …
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Genomics and host response of S. Typhi infections
Abstract: Genomics and host response to S. Typhi infections Mailis Maes, Department of Medicine, St. Edmunds College, University of Cambridge Around 20 million people are diagnosed annually with typhoid fever, caused by the Gram-negative bacterial pathogen Salmonella enterica serovar Typhi (S. …
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Host response of lung cells to virulent Bacillus anthracis
… as a safe site for germination and transport to host lymphatics. This study was the first to report that, unlike their murine counterparts, human alveolar MØs mediate the killing of the majority of internalized virulent B. anthracis spores/vegetative cells via a robust oxidative burst. However, …
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The host response to cancer and cancer-associated cachexia
… of life, and the consequent poor tolerance/response to treatment, cachexia is a major global public health burden. In the first chapter of my thesis, I analyse the usage of ketogenic diets (KD) containing high levels of fats as adjuvant therapies in end-stages of cancer that are associated …
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The Impact of Candida albicans Glycogen on Fitness, Virulence and Host Response
… (OPC) and disseminated candidiasis when normal host immunity is disturbed, while also causing vulvovaginal candidiasis (VVC) in healthy women. Adaptation to different host niches requires rapid and coordinated changes in Candida metabolism and physiology to cope with host immune surveillance and …
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Host response to tuberculosis: impact of diabetes & cellular metabolism of immune cells
Contains fulltext : 178235.pdf (Publisher’s version ) (Open Access)
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Host Response to Plasmodium Infection: Implications for Pathogenesis and Management of Severe Malaria
Cerebral malaria (CM), caused by
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Studies of the Host Response and the Induction of Immunosuppression in Murine Malaria
… and tested for suppression of the immune response to SRBC. Membranes containing fractions Peak I (C), Peak I (G), and the sodium deoxycholate void volume all act as a vaccine against Plasmodium infection and are all without immunosuppressive activity as assayed by the plaque technique. …
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Anti-inflammatory drugs for modulation of host response to biomaterials and application in diabetes therapy
Host response to implanted biomaterials and medical devices poses tremendous challenges to their clinical applications. Today, the quest to mitigate this immunological attack for improved longevity of these devices remains daunting. This thesis aims to explore the use of anti-inflammatory drugs in …
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Identifying Immunological Signatures in Blood Predictive of Host Response to Plasmodium Falciparum Vaccines and Infections Using Computational Methods
… the Plasmodium parasites that cause malaria and host immune system have made it difficult to identify specific mechanisms of vaccine-induced and naturally acquired immunity. After more than half a century of research into potential immunization methods, reliable immune correlates of malaria …
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Immunostimulatory effects of different aspects of aquaculture on the host response in the edible sea urchin, paracentrotus lividus
… of different aspects of aquaculture on the host response of the edible sea urchin, Paracentrotus lividus, which are a prized delicacy (roe) in many Asian and Mediterranean countries. In Chapter 1, the importance of understanding the biology, ecology, and physiology of P. lividus, as well as …
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HOST RESPONSE TO PRIMARY AND SECONDARY CORONAVIRUS EXPOSURES AND POTENTIAL GERMINAL CENTER MECHANISMS ASSOCIATED WITH PROTECTION DURING RE-EXPOSURE
… it was hypothesized that factors such as host sex, age, and pre-existing immunity could influence SARS-CoV-2 infection outcomes. To address this hypothesis, I developed three objectives, leveraging the development of preclinical animal models in order to assess viral pathogenicity and host …
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Models of the Mucosal Inflammatory and Regulatory Immune Pathways: The Role of Host Response in Microbial Persistence and Pathogenesis
… to address the role of the natural host immune response in determining outcomes of infection by a specific microbe including pathogenesis and microbial clearance. Such knowledge is key to devising sophisticated disease intervention strategies. The systems studied are i) Inflammatory …
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Evidence of Water to Human Transmission of Aeromonas Hydrophila: Critical Role of Quorum Sensing in Bacterial Virulence & Host Response
… and AHL pretreatment modulates innate immune response in mice and enhances their survivability during A. hydrophila infection. Further, AHL treated animals exhibited a significantly reduced bacterial load in the blood and other mouse organs, as well as various levels of cytokines/chemokines as …
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Mechanisms of microbial-host interaction during asymptomatic bacteriuria
… to protect against recurrent UTI. To define the host influence on bacterial adaptation during long term E. coli 83972 ABU, we collected sequential isolates from patients that had been inoculated with E. coli 83972 and established stable bacteriuria. The isolates acquired several host-specific …
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