Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 75 for “"host proteins"”.
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Interactions between Cucumber mosaic virus proteins and host proteins
… that introduce virus particles directly into host cells. The 2b viral suppressor of RNA silencing (VSR) encoded by CMV is a potent counterdefence and pathogenicity factor that inhibits antiviral silencing by titration of short double-stranded RNAs. The 2b VSR not only influences infection, but …
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Characterization of intracellular interactions between dengue virus and host proteins
… The genome of dengue virus encodes only ten proteins implying that the virus needs to interact with and utilize several host proteins for replication. In this project, I used high-throughput yeast two-hybrid screening to identify mosquito and human proteins that physically interact with …
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Host Proteins Interact with the Hiv-1 Core to Facilitate and Restrict
<p>Host cell proteins, termed restriction factors, which inhibit viral replication at various stages of the viral life cycle, determine the species-specific tropism of numerous retroviruses. Many members of the TRIM family of proteins act as viral restriction factors. One well-characterized example …
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Identification of host proteins targeted by the flax rust effector protein AvrL567
… flax rust fungus (Melampsora lini) and its flax host (Linum usitatissimum) have served as a successful model system for rust infection for many years. The experiments described in this thesis aim to identify cellular targets of the two M. lini effector proteins AvrL567 and AvrM and elucidate the …
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Identification of host proteins targeted by the flax rust effector protein AvrL567
… flax rust fungus (Melampsora lini) and its flax host (Linum usitatissimum) have served as a successful model system for rust infection for many years. The experiments described in this thesis aim to identify cellular targets of the two M. lini effector proteins AvrL567 and AvrM and elucidate the …
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TICK-FLAVIVIRUS INTERACTIONS: DISCOVERY OF HOST PROTEINS THAT ARE AFFECTED IN VIRUS INFECTION
… 2015. Tick-Flavivirus Interactions: Discovery of Host Proteins That Are Affected in Virus Infection. Major Professors: Catherine A. Hill and Richard J. Kuhn.
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A proteomic approach for studying LTR retrotransposon host factors in saccharomyces cerevisae
… of Ty RNA. Following translation of Ty proteins, virus-like particles (VLPs) assemble in the cytoplasm. VLPs contain Ty RNA and enzymes surrounded by a capsid shell. Specific cellular tRNAs are also packaged within VLPs and serve as primers for reverse transcription of Ty element RNA …
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Trimming Fat Upon Infection: Proteolytic Demyristoylation as a Novel Bacterial Pathogenic Strategy
Host-pathogen interaction is a complex process that involves an array of molecular tools on both sides of the conflict. In the light of growing antibiotics resistance, understanding of virulence factors utilized by pathogenic bacteria is crucial for developing better treatment for infectious …
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Functional and Mechanistic Analysis of Protein Degradation by Human Cytomegalovirus to Uncover Viral Immune Evasion Mechanisms
… infection that is controlled by a multifaceted host immune response. However, immunocompromised patients, including transplant recipients and those with acquired immunodeficiency syndrome, are at a high risk of HCMV-associated morbidity and mortality. HCMV is also the most prevalent infectious …
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A Genetic-Proteomic Approach to Identify Cellular Components that Interact with HIV-1
… However, to date, only a small group of cellular proteins have been shown to be required for viral propagation. In an effort to recover and identify those host proteins that interact in complex with the viral machinery, we have developed a systematic genetic method to select derivatives that can …
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TRP75-Mediated STAT3 Activation Promotes Anti-Apoptotic Signaling and Ehrlichia chaffeensis Infection
… manipulates mononuclear phagocytes by hijacking host cell signaling pathways to promote infection. In part, E. chaffeensis accomplishes host cell manipulation through the actions of secreted effector proteins, including the tandem repeat proteins (TRPs). The most well-characterized TRP, TRP120, …
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Identification and Characterisation of Human Cytomegalovirus-Mediated Degradation of Helicase-Like Transcription Factor
Viruses are known to degrade host factors that are important in innate antiviral immunity in order to infect successfully. To systematically identify host proteins targeted for early degradation by human cytomegalovirus (HCMV), the lab developed orthogonal screens using high resolution multiplexed …
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Chemical Reporters for Investigating Lipidated Proteins at the Host-Pathogen Interface
<p>Lipidation of proteins regulates many cellular processes such as signaling transduction and membrane sorting by modulating protein localization and proteinprotein interactions. As such, defects in protein lipidation can render host cells more susceptible to microbial infection and are also …
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KSHV encoded viral processivity factor, ORF59, regulates multiple pathways for viral replication
… infected cells and identified ORF59 interacting proteins through protein sequencing and LC/MS spectrometry analysis. From a large number of ORF59 interacting proteins, we pursued few candidates for further study including host proteins Nucleolin and MCM4 in addition to viral protein, ORF57. Our …
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Characterization of a Mitochondrial Localizing Molluscum Contagiosum Virus Protein: MC163R
… immune evasion molecules (IEMs). IEMs antagonize host immune responses allowing MCV to evade the host immune system and reprogram the host cell for viral growth. MCV IEMs alter apoptosis (MC159, MC160), deregulate the cell cycle targeting retinoblastoma (MC007), and produce a chemokine homolog …
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Investigation of the Polyprimidine Tract-Binding Protein-Associated Splicing Factor (PSF) Domains Required for the Hepatitis Delta Virus (HDV) Replication
… replication of HDV implies on investigating the host proteins that bind to its genome. The polypyrimidine tract-binding protein-associated splicing factor (PSF), an HDV interacting protein, was found to interact with the carboxy terminal domain (CTD) of RNA polymerase II (RNAPII), and to …
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Structural insights into RNA binding by NusA and interaction studies of Nun with E. coli Nus factors.
… N protein which recruits a number of host proteins called Nus factors. Several of these host proteins which are essential for effective transcription termination and antitermination have been identified, these includes NusA, NusB, NusE and NusG. The subject of this work is mainly …
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Functional Characterisation of Protein Degradation during Human Cytomegalovirus Infection
… has evolved a myriad of strategies to evade the host immune response, including targeting host proteins for degradation. Insights into this viral antagonism can facilitate the development of novel antiviral therapies by restoring the activity of endogenous proteins important for antiviral …
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Understanding the function and structure of herpes simplex virus type 1 pUL55, a novel immune evasion protein
… to stimulate proteasomal degradation of several host proteins in HSV-1 infected cells. Multiple studies to date have used the *dl*1403 mutant strain of HSV-1, engineered to lack ICP0, which has demonstrated the importance of ICP0 activity in the establishment of viral infection in multiple model …
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