Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 129 for “"host factors"”.
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Dengue Virus Host Factors
… dengue virus interacts with its insect and human hosts will facilitate the intelligent design of specific antivirals to combat the disease and enable the selective breeding of mosquitoes resistant to the virus. Although the genomes of the two primary mosquito vectors have been sequenced, the …
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Characterization of Host Factors Affecting Viral Entry
The file named "RINKENBERGER-DISSERTATION-2019.pdf" is the primary dissertation file. Two (2) supplemental video files are also available and may be viewed individually.
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Host Factors That Influence Coxsackievirus B3 Replication and Pathogenensis
… B3 (CVB3), our laboratory has found two critical factors that impact CVB3 replication and pathogenesis. First, we have demonstrated that intestinal bacteria enhance intestinal CVB3 replication. We found that certain specific bacteria (Salmonella enterica) and its cell wall components, like …
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Understanding host factors controlling intracellular killing of Mycobacterium tuberculosis
… of innate immunity is essential for a successful host response to infection with Mycobacterium tuberculosis (MTB) which causes human tuberculosis (TB). Better understanding of host factors controlling the survival of MTB within the macrophage (the primary site of MTB infection) may present …
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Identification of Host Factors Required for Hepatitis C Virus Infection
… strains. In this context, drugs targeting host factors that control HCV infection may be more effective therapies in that the potency of drugs is not affected by viral mutations. For this purpose, more knowledge regarding host factors involved in HCV infection is needed. HCV is known to …
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Molecular Mechanisms and Host Factors Involved in HIV-1 Latency
… virus-1 can stay undetected and unaffected by host immune surveillance and antiretroviral therapy. This phenomenon is called proviral latency and the cells harbouring such viruses are part of the latently infected cell reservoir. In this situation, the viral genome integrates into the host's …
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A proteomic approach for studying LTR retrotransposon host factors in saccharomyces cerevisae
… of retrotransposition. A wide range of cellular host factors involved in the Ty replication cycles has been identified by genetic screens; however little is known about the mechanism by which most of these affect Ty element replication. To complement these genetic approaches we have identified …
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Viral and Host Factors Associated with HIV-1 Vertical Transmission and Pathogenesis
… with adult MDMs. Evaluation of these cellular factors identified genes that fell into several classes including transcriptional activators/repressors, cytokines, and matrix metalloproteinases, all of which may be able to influence HIV-1 gene expression. To explain this differential HIV-1 gene …
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Viral and Cell Type Specific Host Factors that Contribute to Paramyxovirus Antiviral Responses
Activation of host cell responses during viral infection can be a critical factor in determining of viral tropism, dissemination, and pathogenesis. The paramyxovirus simian virus 5 (SV5) is able to establish highly productive, persistent infections of cultured epithelial cells with minimal …
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Characterization of Host Factors and Anti-viral Compounds for Diverse Mosquito-borne Flaviviruses
… therapeutics requires discovery of novel host-virus interactions as well as an informed anti-viral discovery pipeline. We used a genome-scale RNAi-based screen followed by a chemical screen of FDA-approved therapeutics to identify scores of novel dengue virus (DENV) human host dependency …
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West Nile virus versus the host cell: Identification of host factors that modulate infection
There are two competing aspects of virus-host interactions: (i) those that enhance virus transmission and (ii) those that reduce or prevent viral replication and transmission. Each of these types of interactions is critical and both must be investigated to fully understand viral pathogenesis. Cells …
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Ribosomal Proteins RPLP1 and RPLP2 are Host Factors Critically Required for Flavivirus Infectivity by Promoting Efficient Viral Translation Elongation.
… RPLP1 and RPLP2 (RPLP1/2), that are crucial host factors required for translation of flaviviruses and efficient flavivirus infection of human cell lines and Aedes aegypti mosquitoes, which are natural vectors for these viruses. We hypothesized that RPLP1/2 are accessory ribosomal proteins …
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Identification of host factors required for cytosol entry by Shigella flexneri: Results of a genome-wide CRISPR/Cas9 screen
… lyses the vacuole membrane to gain entry to the host cytosol. As a professional cytosol-dwelling pathogen, *Shigella* then overcomes cell-autonomous host defences to establish its replicative niche, before spreading into adjacent enterocytes. Although cytosol entry is a key step in its cellular …
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The Impact of Host Factors on Retroviral Evolution and the Identification of a Novel Receptor That Was Used by an Ancient Primate Retrovirus
… interactions between extinct pathogens and their hosts that occurred millions of years ago. Two of these paleoviruses, chimpanzee endogenous retrovirus 1 and 2 (CERV1 and CERV2), are relatives of modern murine leukemia viruses that are found in the genomes of a variety of old world primates, but …
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Factors affecting diagnostic and prognostic performance of a transcriptomic signature of risk of tuberculosis in HIV-uninfected South African adults
Background Host blood transcriptomic signatures, such as RISK11, have potential as tests for diagnosing and predicting tuberculosis. This thesis aimed to review the literature, evaluate host and non-host factors associated with variability of the RISK11 signature and impact on discriminatory …
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Virus-Host Interactions during Epstein-Barr virus Latent Infection of B cells
… extensive interplay between the virus and normal host factors and processes that are critical for maintenance of a successful latent infection. We sought to expand upon the current knowledge of this interplay in three areas: i) appropriation of the Notch signaling pathway via the host factor RBPJ, …
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High throughput RNA interference based screen for the identification of genes implicated in listeria monocytogenes infection
… uses these proteins to invade and undermine the host immune surveillance system, as well as to survive and propagate within the host cell. Our understanding of how L. monocytogenes infects cells points towards an interplay between bacterial proteins and human host factors. It has become apparent …
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A Role for Mindbomb 1 in Adenovirus Genome Delivery
… number of cellular proteins subsequently termed host factors. Given the virus' dependence on these proteins, host factors therefore represent valuable targets for therapeutic interventions. Still, the identity and function of many of these factors remains unknown. In this body of work, I will …
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Interrogating Host-Parasite Dynamics During Plasmodium Liver Stage Infection
… by an Anopheles mosquito and require both host and vector to complete their life cycle. Once in the host, parasites travel to the liver and undergo an obligatory and asymptomatic liver stage. This elusive stage is necessary to produce blood-infective parasites, to which the cyclical blood …
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"A syndrome so characteristic" Molecular and clinical studies of Fusobacterium necrophorum and Lemierre's syndrome
… for invasion and dissemination. To examine if host factors affecting coagulation and invasion could be important in Lemierre’s syndrome we conducted a retrospective study of 65 patients with Lemierre’s syndrome or other invasive infection with F. necrophorum. Patients with Lemierre’s syndrome …
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