Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 147 for “"host defense"”.
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Host defense mechanisms against opportunistic pathogens
Contains fulltext : 251474.pdf (Publisher’s version ) (Open Access)
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Tissue-encoded Design Principles of Host Defense
Inflammatory diseases have been rising in incidence over the past few decades and are a result of inappropriate activation of tissue-resident immunity. This inappropriate activation can be derived from any number of cell types, including immunoregulatory functions of non-immune cells such as …
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Regulatory networks of host defense against Borrelia burgdorferi
Contains fulltext : 207619.pdf (Publisher’s version ) (Open Access)
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Bioinorganic Chemistry of the Human Host-Defense Protein Calprotectin
… follow. Chapter 1: Bioinorganic Chemistry of the Host Pathogen Interaction. Transition metal ions are required for all forms of life. During the course of infection, pathogenic microorganisms must acquire transition metals from the host. Three metals of interest from this standpoint are iron, …
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Metal sequestration of the host-defense protein human calprotectin
… (Fe), and zinc (Zn) to colonize the mammalian host and to cause disease. As part of the first line of defense against pathogenic infection, the host innate immune response deploys a number of metal-chelating host-defense factors that restrict the access of nutrient metals from these microbes. …
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Host-Defense Function of Anuclear Polymorphonuclear Neutrophil in Lung Injury
… inflammatory lung injury. Unlike PMN, the host defense function of PMNcyto waned over time, first observed by in vivo imaging loss in velocity. Upon further investigation using seahorse assay, we observed a loss in mitochondrial functions. Mitochondrial transplantation restored the host …
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Antibacterial peptides - key players in host defense at epithelial surfaces
Innate host defense mechanisms at epithelial surfaces are important to prevent bacterial invasion. Streptococcus pyogenes, group A streptococcus (GAS), has an affinity for epithelial cells and cause pharyngitis. During streptococcal pharyngitis, high concentrations of the chemokines CXCL9/MIG, …
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HOST DEFENSE PEPTIDES OF THE COAGULATION SYSTEM AND THEIR THERAPEUTIC POTENTIAL
… cascades. Emerging evidence suggests that host defense peptides (HDPs) may be potential lead structures in sepsis treatment due to their ability to modulate innate immune responses as well as being directly antimicrobial. From that perspective, this thesis aimed to identify and characterize …
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Intestinal Epithelial Cell Intrinsic IL-1R Signaling in Host Defense and Inflammation
Pages viii-xix are misnumbered as pages vi-xvii.
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The Role of The C5A Receptor In Host Defense Against Listeria Monocytogenes
… that the C5a receptor is essential for host defense. C5aR-/- mice have reduced survival and increased bacterial burden in the liver and spleen in comparison to WT mice. Surprisingly, C5aR-/- mice also have a dramatic reduction in splenocyte numbers resulting from elevated cell death as …
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Discovery and functional evaluation of a host defense peptide from Rana amurensis
… possibility to replace traditional antibiotics. Host-defense peptides in amphibians skins with various biological activities are a rich source for discovering new AMPs. This thesis amid to discover and functionally study a new AMP from the skin secretions of Rana amurensis. A cDNA encoding a new …
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The Role of Human Guanylate Binding Proteins in Host Defense and Inflammation
… pathogens have evolved to replicate within host cells. While a number of these pathogens reside within vacuolar compartments, others escape from host endosomal pathways to replicate intracytosolically. To counter microbial invasion, host cells employ numerous defense proteins to limit …
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A molecular investigation of the antimicrobial functions of the human S100 host-defense proteins
The human host is continually exposed to potentially harmful organisms and the innate immune response is the first line of defense against microbial invasion. One strategy employed by the human innate immune system includes the release of antimicrobial host-defense proteins (HDPs). The goal of this …
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Identification of an Interferon Signaling Pathway Linking Membrane Cholesterol Accessibility to Host Defense Against Pathogens
… a multipotent cytokine that is critical to the host innate immune defense against bacterial infection, and functions through transcriptional induction of hundreds of IFN-γ stimulated genes (γ-ISGs). However, the antibacterial roles of many γ-ISGs remain poorly defined. Here, I describe my …
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Host Defense Mechanisms in the Crayfish: the Effect of Injection with Live or Killed Bacteria.
<p>An increase in attachment of SRBCs to <em>Procambarus clarkii</em> hemocytes has been shown after the crayfish were injected with a live or killed <em>Pseudomonas</em> strain RS2b. The increase in attachment occurred at 8 hours post injection and peaked at 24 hours for both experimental groups. …
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<i>Plasmodium</i>-Induced Nitrosative Stress in <i>Anopheles stephensi</i>: The Cost of Host Defense
… parasite-induced nitrosative stress, cellular defenses in the mosquito may be induced to minimize self damage. I proposed that peroxiredoxins (Prx), enzymes that can detoxify peroxides and peroxynitrite, may protect <i>A. stephensi</i> from nitrosative stress. Six Prx genes were identified in …
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Developmental gene expression of host defense peptides in immune organs and the small intestine of turkey poults (Meleagris gallopavo)
Host defense peptides (HDPs) are a large group of small positively charged peptides that play an important role in innate immunity. Their role is more critical at early ages when other components of the immune system have not fully developed. There are three classes of avian HDPs: avian beta …
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Temporal and Tissue Specific Changes in Expression of Nutrient Transporters and Host Defense Peptides in Young Broilers during Salmonella and Campylobacter infections
… on mRNA abundance of nutrient transporters and host defense peptides (HDPs) during a Salmonella or a Campylobacter challenge in young commercial broilers. Comparisons were made between non-challenged and challenged (106, 107, or 108 colony forming units of Salmonella or Campylobacter) broilers …
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