Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 51 for “"hormone therapy"”.
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CaV1.3 Ion channel expression and hormone therapy in prostate cancer
… localised PCa is commonly treated with radiotherapy or surgery where recurrent tumours are treated with hormone therapy, such as androgen-deprivation therapy (ADT) and/or androgen receptor (AR) antagonists, e.g. Enzalutamide (ENZ). Castrate-resistant disease, where tumours become resistant to …
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Understanding the decision making process of beginning hormone therapy for trans individuals: a grounded theory study
… of need often leading to self-prescription of hormones, and the compromising gate-keeping roles of professionals working with this population. Seven participants, who had all made the decision to take hormones, were interviewed. Semi-structured interviews addressed their help seeking behaviour …
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RESEARCH AND OPTIMIZATION OF PROSTATE CANCER HORMONE THERAPY // ИЗСЛЕДВАНЕ И ОПТИМИЗИРАНЕ НА ХОРМОНОТЕРАПИЯТА НА КАРЦИНОМА НА ПРОСТАТНАТА ЖЛЕЗА
Карциномът на простатната жлеза (КПЖ) е често срещано злокачествено заболяване при мъжете. В страните от Европа той заема второ място като причина за смърт след карцинома на белия дроб. За България карцинома на простатната жлеза е на второ място след карцинома на дебелото черво. Клиничната му изява …
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Physical activity and muscle function in females: Impact of ovarian hormones, bazedoxifene, and estrogen receptor alpha
… evaluate the literature to determine if hormone therapy increases physical activity in postmenopausal women, 2) determine the effects of estradiol and progesterone on physical activity and skeletal muscle function in female mice, and 3) determine the effects of bazedoxifene on the …
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Cardiovascular Disease: Prevention and Management
… events (venous thromboembolism) in women taking hormone therapy (HT).1–3 However, these drugs have little effect on heart failure outcomes, an important source of morbidity and mortality in the United States. This dissertation will have two projects concerning statin effectiveness and adverse …
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Conjugated Estrogen Receptor Probes: An Evaluation of Fluorophores, Photolabile Groups, Estrogenic Ligands, and the Nature of the Attaching Chain
… in breast tumors, and their responsiveness to hormone therapy. However, the correlation is not perfect; about 40% of women with measurable tumor receptor levels do not respond to hormone treatment. The work described herein was undertaken in order to improve the predictability of hormone …
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Regulation of Micrornas by 17β-Estradiol in the Aging Female Brain
<p>Hormone Therapy (HT) is used to increase the 17β-estradiol (E2) levels in women who are going through the menopausal transition to alleviate the negative symptoms associated with menopause and decrease the risk of chronic diseases. Clinical and basic science research had previously shown that HT …
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ESTROGEN, VASCULAR INFLAMMATION, AND INTERLEUKIN-17 IN RELATION TO ATHEROSCLEROSIS IN A FEMALE NONHUMAN PRIMATE MODEL
… is unknown. Postmenopausal estrogen therapy (ET) mediates atheroprotection in part through anti-inflammatory effects; however, the effects of ET on Th17 cells and IL-17 are poorly understood. The data from observational and experimental studies have shown that postmenopausal ET …
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Living with Changing Health: Perimenopause among Chinese Women in Taiwan
… as perimenopausal and who were not using hormone therapy were interviewed. Data were generated from interviews which were conducted in Mandarin. Living with Changing Health was the core category for describing and guiding the process of perimenopause. During this process, Awareness was …
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A Clinical audit of the transgender unit at Groote Schuur hospital
… to other gender affirming services, such as hormone therapy, plastic and reconstructive surgery, psychosocial, and legal services. Objectives This clinical audit aimed to gain a clearer understanding of the service and areas within the service which could be improved. To this end the general …
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Computational Studies on Group 14 Elements (C, Si and Ge) in Organometallic and Biological Compounds.
… C analog in vitro and in vivo studies in modern hormone therapy. A computational investigation was carried out on the synthesized decapeptides focusing on position 5 containing Si and Ge. The results have shown that there are some differences in C, Si and Ge-containing analogs. However, further …
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An implantable device for localized drug delivery and sensing
… as cancer, vaccinations, pain management, and hormone therapy. Localized drug delivery systems reduce the amount of drug required for a therapeutic effect and the severity of side effects. Delivery of multiple chemicals has been demonstrated previously from a polymeric microreservoir device. …
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Investigation of the anti-cancer effects of rosemary (Rosmarinus Officinalis L.) extract in human breast and prostate cancer cells
… is characterized by resistance to chemo and radiotherapy thus, finding new approaches to inhibit it are urgently needed. Similarly, prostate cancer is typically characterized by the expression of androgen receptor (AR) and prostate-specific antigen (PSA). Prostate cancer that is AR positive can be …
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Current Genetic Counseling Practice Following Positive Non-Invasive Prenatal Testing For Sex Chromosome Abnormalities
… undiagnosed SCAs who could benefit from growth hormone therapy, early intervention, and/or targeted surveillance may be missed. There is a need for professional guidelines to help improve clinical care for patients with NIPT results positive for SCAs.</p>
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OTULIN's Novel Regulatory Mechanisms in Genotoxic and Inflammatory NF-kB Signaling
… (TNBC) is aggressive but cannot be treated with hormone therapy or molecular therapy due to the lack of a target. Chemotherapy is a systemic treatment that works by attacking rapidly growing cells, which is initially more effective for TNBC patients than those individuals with the hormone …
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My Identi T: Improving Mental Health Outcomes Through Group Support In Pre-Treatment Transgender Teens
… to transgender youth awaiting gender-affirming hormone therapy during protracted wait times to treatment initiation. This clinical improvement project included a group of ten TGY, ages 13-17. Eight informational virtual meetings were held twice monthly for four months. Clinical assessments …
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Dermatological Concerns For Women and Girls With Turner Syndrome
… manifestation history, special issues in growth hormone therapy, and family history. We analyzed 241 responses from the UTHealth TS registry, TS Society of the United States, and TS social media groups. Although many dermatological concerns present during the first few decades of life, the …
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Bioimpedance spectroscopy of breast cancer cells: A microsystems approach
… negative breast cancer (TNBC) cell lines and a hormone therapy resistant model of breast cancer in order to improve our understanding of the bioimpedance spectra of breast cancer subtypes. Third, we explored strategies to improve the sensitivity of the microelectrodes to bioimpedance …
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Women's decisions and decisional conflict regarding long term hormone replacement therapy.
Long term preventive hormone replacement therapy (LTP-HRT) is attracting considerable attention for its potential in reducing the incidence of coronary heart disease and osteoporosis associated fractures in post-menopausal women. The study objectives were: (1) to describe women's decisions and …
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Expectations and Experiences of Gender Affirming Healthcare in Transgender Individuals
… These treatments can include gender affirming hormone therapy (GAHT) and various surgeries. This research, which was influenced by PPI (patient and public involvement) , aimed to explore the factors associated with experiences of gender affirming healthcare through two studies: (i) a systematic …
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