Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"hormone sensitive lipase"”.
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Hormone-Sensitive Lipase - New roles in adipose tissue biology
… importance in order to combat this disease. Hormone-sensitive lipase (HSL) is a key enzyme in the mobilization of fatty acids from acylglycerols in adipocytes, but also plays important roles in other cell types. The aim of this thesis has been to study the consequences of a targeted …
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Effects of Neuropeptide Y on Adipocyte Metabolism
… was mediated by increased phosphorylation of hormone sensitive lipase. In contrast, NPY did not alter the expression of several key lipolytic and lipogenic enzymes/proteins or glucose uptake. Our results revealed a novel cross talk between the NPY and 3-adrenergic signaling pathways in …
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The impact of carbohydrate ingestion on the regulation of fat oxidation following exercise
… (ACC), 5'AMP-activated protein klnase (AMPK) and hormone sensitive lipase (HSL) increased with exercise (p<0.05). ACC and AMPK phosphorylation in the CHO trial was lower at 1 h post than in the PLA trial (pc0.05). HSL phosphorylation remained above baseline at 1 h post in the PLA but not the CHO …
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An exploration into the proteins that regulate skeletal muscle lipid metabolism
… levels of IMTG turnover in comparison to insulin sensitive and trained individuals. IMTG stores are used as an energy substrate during 1 h of moderate-intensity exercise in trained individuals only and can be increased by consumption of a high fat, high calorie (HFHC) diet in sedentary and trained …
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Non-canonical roles for STAT1 and STAT2 in mitochondrial biogenesis and fasting homeostasis.
… during starvation. We see that activation of hormone sensitive lipase which is the rate limiting step of lipolysis is attenuated in the adipose tissue of STAT1-/- mice and that there is less lipid accumulation in the livers of STAT1-/- compared to wild-type mice. The mechanism of STAT1’s role …
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Nutritional and Health Consequences of Feeding Diets of Varied Macronutrient Composition and Subjected to Select Processing Conditions in Domestic and Wild Felids
… and altered adipose tissue gene expression (hormone sensitive lipase, leptin, and insulin receptor). Feeding high-protein diets did not prevent weight gain in our studies, but may be more effective if limit-fed. As high-protein and raw diets gain popularity with consumers, further research …
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Lipid metabolism in the pancreatic beta-cell. Implications for insulin secretion.
… beta-cell, where they are essential for adequate hormone release, but may also exert a long-term toxic effect, leading to beta-cell dysfunction. Our studies in mice, where insulin resistance and glucose intolerance was induced by high fat diet, showed that beta-cells compensate by increasing …
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Metabolic and endocrine adaptations to heat stress in lactating dairy cows
… cAMP-response element binding protein (CREB) and hormone sensitive lipase, both located downstream of β-adrenergic receptor, were decreased in HS, but not in thermoneutral conditions, another indicator of impaired adrenergic signaling. In contrast, IR and AKT phosphorylation were increased in HS …
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Fatty Acid Fate In Determining Oxidation And Inflammation In Adipose Tissue
… which was greatly potentiated by inhibition of hormone sensitive lipase (HSL). In 3T3-L1 adipocytes, limiting lipolysis potentiated the induction of oxidative genes; while in contrast, promoting the accumulation of intracellular FAs suppressed their induction by Β-AR stimulation. Interrogation …
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Omics Techniques Applied to Diabetes Research - Focus on HSL-Null Mice and Clonal β-Cells
… in this thesis, two models were analyzed: hormone-sensitive lipase (HSL) null mice and a pancreatic clonal β-cell line to study the mechanisms underlying insulin resistance and insulin secretion perturbations, respectively. To achieve this, techniques allowing a global analysis of the …