Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 82 for “"hormone receptors"”.
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Interactions of Steroid Hormone Receptors With Coactivators and DNA
II Steroid hormone receptors (HR) activate gene transcription through binding to ligands, locating specific hormone response elements (HREs) on DNA, recruiting coactivators and then chromatin remodeling complexes and ultimately the basal transcription machinery. In vivo data suggests that the …
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Synthesis of Purine Derivatives as Probes of Hormone Receptors
Made available in DSpace on 2014-12-13T20:10:20Z (GMT). No. of bitstreams: 1 7804173.pdf: 4957165 bytes, checksum: 32cfa701808e660b6b3f7170b110349f (MD5) Previous issue date: 1977
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Molecular Dynamics Study of Hormone Receptors Binding DNA and Hormones
… and non-specific DNA, and binding/unbinding of hormones to/from retinoic acid receptor and thyroid hormone receptor. In the DNA dodecamer, d(CGCGAATTCGCG), two Adenine residues, individually or jointly, were replaced with the 2 '-deoxy-7-(hydroxymethyl)-7-deazaadenosine (hm7c 7dA) analogue. The …
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Second-site inhibitors of the estrogen and androgen hormone receptors
The estrogen and androgen receptors are members of the nuclear hormone receptor protein superfamily and play an important role in the development of primary and secondary female and male sexual characteristics. Although necessary for proper development, in certain contexts activation of these …
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The cloning of novel gonadotropin-releasing hormone receptors by polymerase chain reaction
Gonadotropin-releasing hormone (GnRH), a central regulator of reproductive function in all vertebrates, exerts its effects via binding to the GnRH receptor (GnRHR) in the pituitary gonadotrophs. The GnRHR is a member of the G-protein coupled receptor (GPCR) superfarnily. A second form of the GnRHR …
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Generation and use of new tools for the characterisation of gut hormone receptors
Enteroendocrine hormones released from the intestine following food intake have several roles in the control of metabolism, some of which are exploited therapeutically for the treatment of type 2 diabetes. Within this thesis, focus has been on the receptors of the gut hormones glucagon-like …
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The Regulation of Cholesterol Absorption: Nuclear Hormone Receptors and Niemann-Pick C1 Like 1
… to investigate the potential role of nuclear receptors in regulating essential steps in this process. Here, we show that a candidate component of the cholesterol transport machinery, caveolin-1 (CAV1), is neither required for intestinal cholesterol transport or sensitivity to the novel …
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Hormonal modulation of sex steroid hormone receptors and oncogenes in human breast cancer cells
… the effects of estrogen, progestin and hormone antagonists on the levels of estrogen receptor (ER), progesterone receptor (PR) and HER-2/neu mRNA and protein have been studied in human breast cancer cell lines using cDNA and antibody probes. In all studies, protein response closely …
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Gene structure, transcripts and transcriptional regulation of primate type II gonadotropin-releasing hormone receptors
Includes bibliographical references.
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Diverse Immune Responses Mediated by Beta-Adrenergic and Corticotropin-Releasing Hormone Receptors in a Model of Pneumococcal sepsis
… catecholamines and corticotropin-releasing hormone (CRH) on immune responses involved in the pathogenesis of Streptococcus pneumoniae (S. pneumoniae) infection implementing both in vitro and in vivo methodology. Dendritic cells play a pivotal role in antigen presentation and cytokine …
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Cloning and characterisation of gonadotropin-releasing hormone receptors from species in non-mammalian vertebrate classes : amphibia and osteichthyes
Two or more forms of gonadotropin-releasing hormone (GnRH) have been isolated from most vertebrate species. In most species, GnRH variants have been shown to occur in distinct areas of the peripheral and central nervous systems, the gonads and other peripheral organs. Although GnRH is a primary …
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Development and Application of a Fluorescence Anisotropy Microplate Assay for Analyzing the Interaction of Steroid Hormone Receptors With DNA and Coactivators
… to the binding of estrogen and progesterone receptors to their respective DNA response elements. The FAMA is also the first system suitable for screening large compound libraries to identify novel compounds that modulate binding of steroid receptors to their DNA response elements. …
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Glycoprotein hormone receptors in sea lamprey (Petromyzon marinus): Identification, characterization and implications for the evolution of the vertebrate hypothalamic-pituitary-gonadal/thyroid axes
… interaction between pituitary glycoprotein hormones GpH (lutropin LH, follitropin FSH, thyrotropin TSH) and glycoprotein hormone receptors GpH-R (LH-R, FSH-R and TSH-R respectively).</p><p>GpHs and GpH-Rs originate in a common ancestral ligand/receptor pair. Their duplications were followed …
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The role of the chicken gonadotropin-releasing hormone receptor C-terminal tail in expression and coupling
… tail of the chicken gonadotropin-releasing hormone receptor was determined by testing the activity of a series of chicken gonadotropinreleasing hormone receptors with progressive deletions in their carboxyl terminus. The 55 amino acid carboxy terminal tail of the chicken …
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Novel genotoxins that target estrogen receptor- and androgen receptor- positive cancers : identification of DNA adducts, pharmacokinetics, and mechanism
… tumor cells that aberrantly express steroid hormone receptors. Many human breast cancers express high levels of the estrogen receptor (ER), and most prostate cancers express the androgen receptor (AR). We reasoned that the potential genotoxic effect of DNA adducts would be increased in target …
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Estrogen Receptor and Progesterone Receptor Synthesis and Degradation in Target Cells
The rates of synthesis and degradation of steroid hormone receptors are crucial factors in maintaining hormone responsiveness in target tissues. It was the intent of this study to determine the turnover of the estrogen receptor (ER) and progesterone receptors (PR) in rat uterine and human breast …
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A molecular dynamics study of hormone receptor-DNA binding
… are utilized to investigate the binding of hormone receptors to DNA. The hormone receptors constitute a family of gene regulatory proteins that can be divided into two subfamilies based on the sequence of DNA to which a receptor binds with high affinity. The glucocorticoid receptor subfamily …
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The synthesis and evaluation of estrogenic probes for in vitro and in vivo studies
… in developing molecular probes for steroid hormone receptors, and in particular, the estrogen receptor (ER), in order to further elucidate its structure and function, and to aid in the clinical evaluation and treatment of patients suffering from breast cancer. This thesis focuses on the …
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Inhibition of the endosomal recycling pathway to overcome resistance to cancer therapies
… This thesis focuses on two clinically relevant hormone receptors that are strongly linked to the development and progression of breast and prostate cancer linked to disease development and progression, the estrogen receptor alpha and the androgen receptor. The aim of this project was to confirm …
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