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Showing 1 to 20 of 137 for “"hormone receptor"”.

  1. Gonadotropin releasing hormone receptor ligand interactions

    Flanagan, Colleen ADivision of Chemical Pathology1995

    The decapeptide, gonadotropin releasing hormone (GnRH), is the central regulator of reproductive function. It binds to receptors on the gonadotrope cells of the pituitary and stimulates release of luteinizing hormone (LH) and follicle stimulating hormone (FSH). Eleven different structural forms of …

    cape-town Repository record

  2. Cloning and charaterisation of the Thyrotrophin-releasing hormone receptor and Gonadotrophin-relasing hormone receptor from chicken pituitary gland

    Sun, Yuh-ManDivision of Chemical Pathology1998

    The hypothalamic hormones, thyrotrophin-releasing hormone (TRH) and gonadotrophin-releasing hormone (GnRH), play pivotal roles in the growth and sexual maturation of chickens. In chickens, TRH regulates the release and synthesis of thyrotrophin (TSH) and also acts as a growth hormone-releasing …

    cape-town Repository record

  3. Epigenetic Regulation of Nuclear Hormone Receptor DAX-1

    Heskett, Michael B2015

    <p>DAX-1 (NR0B1) is an orphan nuclear receptor that plays a key role in the development and maintenance of steroidogenic tissue in mammals. Dax-1 is also expressed in mouse embryonic stem (ES) cells and is required to maintain pluripotency. Duplication of the X-chromosome in the region containing …

    usfca Repository record

  4. Molecular Mechanisms Underlying Functions of Juvenile Hormone Receptor

    Li, MengVirginia Tech2013

    Juvenile hormone (JH) is one of the principal hormones that regulate insect development and reproduction. Accumulating evidence suggests that Methoprene-tolerant (Met) protein is a nuclear receptor of JH. Work by others has shown that Met is capable of binding JH at physiological concentration. An …

    vt Repository record

  5. A molecular dynamics study of hormone receptor-DNA binding

    Bishop, Thomas ConnorUniversity of Illinois at Urbana-Champaign2011

    … are utilized to investigate the binding of hormone receptors to DNA. The hormone receptors constitute a family of gene regulatory proteins that can be divided into two subfamilies based on the sequence of DNA to which a receptor binds with high affinity. The glucocorticoid receptor subfamily …

    uiuc Repository record

  6. Ligand-induced selective signalling at the gonadotrophin releasing hormone receptor

    Coetsee, Marla CatherineDivision of Medical Biochemistry2008

    The pituitary gonadotrophin releasing hormone (GnRH) receptor regulates reproduction by activation of Gq/11 proteins. In contrast, GnRH receptors at extrapituitary sites induce anti-proliferative effects that do not correlate with Gq/11 activation. We propose that the two endogenous ligands, GnRH I …

    cape-town Repository record

  7. IQGAP1 is a novel effector of gonadotropin-releasing hormone receptor signaling

    Alqahtani, Huda A., author, Amberg, Gregory, advisor, Clay, Colin, committee member, Tamkun, Michael, committee member, DeLuca, Jennifer, committee memberColorado State University. Libraries2023

    Stimulation of gonadotropin-releasing hormone (GnRH) receptors on the surface of anterior pituitary gonadotrope cells is a key signaling event for the hypothalamic-pituitary-gonadal axis. One important downstream component of GnRH receptor signaling is activation of the mitogen-activated protein …

    colostate Repository record

  8. Evaluating luteinizing hormone receptor signaling using the cyclic AMP reporter ICUE3

    Hadhoud, Giuma E., author, Roess, Deborah A., advisor, Barisas, George, advisor, Crans, Debbie C., committee memberColorado State University. Libraries2018

    The luteinizing hormone (LH) receptor is a member of the G protein-coupled receptor family and the subfamily of glycoprotein hormone receptors. The LH receptor plays a vital role in normal development and in the function of the gonads. The LH receptor is expressed in interstitial cells, thecal …

    colostate Repository record

  9. A functional analysis of growth hormone receptor promoter regions in swine

    Denton, Alicia NicoleUniversity of Missouri--Columbia2025

    [EMBARGOED UNTIL 08/01/2026] Growth hormone (GH) and its receptor (GHR) play critical roles in regulating growth, development, and reproductive function in animals. GHR expression in the liver is critical for postnatal growth and is regulated by tissue-specific promoters. While promoter 1 (P1) is …

    missouri Repository record

  10. Investigating luteinizing hormone receptor signal transduction using the cyclic AMP reporter ICUE1

    Huang, Xin, author, Roess, Deborah A., advisor, Barisas, B. George, committee member, Crans, Debbie C., committee memberColorado State University. Libraries2010

    … involved in initiation of signaling by LH receptors have been under active investigation because they play important roles in human fertility and development of gonadal tumors. Assay of cAMP levels in response to hormone treatment is usually used to demonstrate LH receptor activation and …

    colostate Repository record

  11. EFFECT OF CONSTITUTIVELY ACTIVATED LUTEINIZING HORMONE RECEPTOR ON THE MOUSE REPRODUCTIVE SYSTEM

    Hai, Lan2017

    … EFFECT OF CONSTITUTIVELY ACTIVATED LUTEINIZING HORMONE RECEPTOR ON THE MOUSE REPRODUCTIVE SYSTEM MAJOR PROFESSOR: Dr. Prema Narayan The luteinizing hormone/chorionic gonadotropin receptor (LHCGR) is crucial for fertility, and genetic mutations in LHCGR cause adverse effects in reproductive …

    siu-theses Repository record

  12. Investigating the role of growth hormone receptor in oesophageal squamous-cell carcinoma.

    Krivochiev, BorisDepartment of Medicine2013

    … diagnostic techniques and therapies. The growth hormone (GH) signalling axis is important for proper cellular and organ system function. The axis has been shown to play a role in a number of cancers.

    cape-town Repository record

  13. Internalisation of the type II gonadotropin-releasing hormone receptor of marmoset monkey

    Ronacher, KatharinaDivision of Medical Biochemistry2003

    The mammalian type II GnRH receptor has a C-terminal tail unlike the mammalian type I GnRH receptor, which uniquely lacks the cytoptasmic C- terminal domain. lnternalisation of a mammalian type ll GnRH receptor has never been investigated, therefore this thesis studies the internalisation pathway …

    cape-town Repository record

  14. Drosophila Ovarian Stem Cell Establishment is Regulated by Nuclear Hormone Receptor ftz-f1

    Berghout, Hanna E.East Carolina University2017

    … is known about how extrinsic signals, such as hormones, affect stem cell fate and function. The highly characterized Drosophila melanogaster steroid hormone ecdysone regulates germline stem cell (GSC) proliferation and self-renewal, as well as oogenesis and metamorphosis. Though many genes, …

    ecu Repository record

  15. Decreased Triiodothyronine Binding to the Hepatic Nuclear Thyroid Hormone Receptor in the Diabetic Mouse

    DeWind, Thomas J.

    … m</em> mouse has abnormal thyroid hormone levels and indications of thyroid hormone resistance. To investigate the basis of these abnormalities, the hepatic nuclear thyroid hormone receptor was extracted with 0.4 M KCl, 1.1 mM MgCl<sub>2</sub>, 20 mM Tris/HCl, pH 7.9 from hepatocyte …

    loma-linda Repository record

  16. Effect of the ligands of thyroid hormone receptor on non-alcoholic fatty liver disease

    KOWALIK, MARTA ANNAUniversità degli Studi di Cagliari2009

    … Here, we examined the effect of the thyroid hormone triiodothyronine (T3) and the agonist of the thyroid hormone receptor β isoform (TRβ), GC-1, on fatty liver and steatohepatitis induced in rodents by a choline-deficient, methionine-restricted (CMD) diet. Male Fischer rats fed the CMD diet …

    cagliari Repository record

  17. Growth Hormone and Melanin-Concentrating Hormone receptor in the regulation of energy balance and metabolism

    Bjursell, Mikael2007

    … responses to maintain a steady balance. Growth hormone (GH) and melanin-concentrating hormone (MCH) act in the CNS to influence the energy balance and may be connected to the peripheral signals ghrelin and leptin. The overall aim of this thesis was to investigate how these different hormonal …

    goteborg Repository record

  18. EGF module-containing mucin-like hormone receptor 2 and its role in human immune privilege

    Song, Helen2014

    … mouse, the macrophage adhesion G protein-coupled receptor (ad-GPCR) molecule, F4/80, is required for the development of regulatory T cells in two models of tolerance, the eye and gut. Since F4/80 is not expressed in humans, the purpose of this research is to determine the human analog of F4/80. …

    bu Repository record

  19. Identifying and Analyzing Human Genetic Variation through a Key Example in the Growth Hormone Receptor Gene

    Resendez, SkylerState University of New York at Buffalo2022

    Ph.D.

    buffalo Repository record

  20. The Role of the Ubiquitin-Proteasome System in the Regulation of Nuclear Hormone Receptor-Dependent Transcription

    Prenzel, Tanja2012

    Nukleare Hormonrezeptoren (NHRs) sind Liganden-abhängige Transkriptionsfaktoren mit breitem physiologischem sowie pathophysiologischem Funktionsspektrum. Molekulare Therapien die sich gegen NHRs richten, stellen eine optimale Behandlung einiger humaner Krankheiten dar. Der Östrogenrezeptor ist …

    goettingen Repository record

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