Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"hormonal signalling"”.
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Investigating persistent organic pollutants as endocrine disruptors of androgen receptor signalling
… are a part of everyday life and may mimic hormonal signalling in wildlife and humans. These exogenous mixtures or substances are called endocrine disrupting chemicals and may lead to adverse health effects in those exposed. Persistent organic pollutants (POPs) are a class of organic …
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Investigating Pathogenic Mechanisms and Biomarkers in Alzheimer’s Disease
… metabolic dysfunction, and impaired hormonal signalling, and to propose a novel approach to measure in vivo biomarkers in blood samples from neurodegenerative disease patients. More specifically, findings presented in this thesis indicate a role for pro-inflammatory interleukin-6 …
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Novel insights into the molecular mechanisms of endocrine resistance in ERα positive breast cancer
… dissertation reinforces FOXA1 independence of hormonal signalling, it identifies ETV6 as a novel ERα and FOXA1 co-factor that drives a more proliferative phenotype and proposes alternative therapies for the endocrine refractory phenotype.
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THE INTERGENERATIONAL IMPACT OF ENVIRONMENTAL EXPOSURES: MOLECULAR INSIGHTS FROM MODELLING PLURIPOTENCY TRANSITIONS THROUGH THE HUMAN GERMLINE
… Considering the central role of endocrine signalling during development, in this PhD thesis, I tackle these challenges by focusing on the paradigmatic case of the intergenerational impact of endocrine disrupting chemicals (EDCs), widespread compounds that interfere with hormonal signalling …
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Spatiotemporal Interaction Networks in Plant Development
… regulation pivots on perpetual modulations of signalling, homeostasis, formation of biochemical patterns and mechanical stresses. Here, we advance the mechanistic insights across three areas of plant development: de novo vascular differentiation in the shoot apical meristem, regulation of cell …