Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"homophilic"”.
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Homophilic and Heterophilic Interactions Among Cadherin Cell Adhesion Molecules
… did not exhibit much variation in either the homophilic or the heterophilic interactions. The two outer bonds (weaker) which are attributed to EC2/EC2 and EC1/EC1 binding, exhibit the greatest variation in bond strengths. In contrast to current thinking, these data show that there is no …
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Regulation of Homophilic and Heterophilic Adhesion Among Classical Cadherins
… cells as a result of both heterophilic and homophilic binding. However, I also showed that lateral cadherin clustering is not a cadherin-specific response. These results are important because they suggest that cadherin-dependent differences in intracellular signaling may play a greater role …
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Cells and force transduction
… RTK binding partner. These results suggest that homophilic ligation in trans- and cadherin association with cognate receptor tyrosine kinase in cis comprises a combinatorial, mechano-chemical switch. That is, specific combinations of cadherin, ligand, and RTK is required for force-activated …
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Probing Biological Systems at the Single Molecule Level: Studies of the Homophilic Binding of the Neural Cell Adhesion Molecule (Ncam) and Phase Dependent Lipid Anchorage Strength
Force probe measurements were also used to study environmental effects on the intermolecular strength of lipids within a membrane. In this case the anchorage strength of lipids in fluid versus gel lipid layers was probed to determine how temperature affects the adhesion properties between adjacent …
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Mine the node association: Dig into the essence of graphs
… association models, which includes 4 parts: (1) homophilic association mining in static graph; (2) homophilic association mining in dynamic graph; (3) heterophilic association mining in static graph; and (4) heterophilic association mining in dynamic graph. First, regarding homophilic association …
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Cadherin recognition and specificity
… phase. Second, the differences between cadherin homophilic and heterophilic interactions were investigated. The measurements showed that the properties of both heterophilic and homophilic bonds are similar. Surprisingly, Rac1 activation triggered by cadherin adhesion showed a greater response to …
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Reexamining actin polymerization in maintaining cadherin mediated cell-cell adhesion
… maintains cell-cell cohesion by converting weak homophilic bonds between the cadherin cell adhesion molecules into strong adhesion. However, the most popular models to explain the role of actin at the junction do not require dynamic actin networks. According to these models, actin polymerization …
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Structure and function of the R2B adhesive receptor tyrosine phosphatases
… structure, with no clear molecular driver of homophilic specificity. A system for inducible cell-aggregation assays has been developed, which will allow future research into the homophilic specificity of R2B receptor ECDs.
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Refugee entrepreneurship in Malawi: the nexus between social capital and entrepreneurship among refugees in adversity
… that refugees’ entrepreneurs utilize, namely homophilic networks(connections, affiliations, bonds, or linkages developed among groups or individuals sharing similar characteristics, aspirations, purposes, or intentions), bricolage, diversification, and adapting supply chains around …
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Cadherin specificity in adhesion and mechanotransduction
… of the strengths and dissociation rates of homophilic and heterophilic cadherin bonds. Measurements conducted with chicken N-cadherin, canine E-cadherin, and Xenopus C-cadherin demonstrated that all three cadherins cross-react and form multiple, intermolecular bonds. The mechanical and …
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Identification and functional characterization of two patterning genes, Zic4 and Ten_m3, in topographic map formation of the visual pathway
… phenotype seen in mice lacking Tenm3, a type II homophilic transmembrane receptor and transcriptional regulator. Using intrinsic signal optical imaging techniques, I characterized the functional properties of primary visual cortical retinotopic maps in Zic4 and Ten_m3 null mice and identified …
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Mechanotransduction at cell-cell contacts
… between force transduction triggered by homophilic versus heterophilic cadherin bonds that could differentially influence cell mechanics. I further investigated the mechanism of force transduction at cadherin junctions, as described in Chapter 4 of this thesis. Chapter 4 specifically …
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Biophysical Characterization Of A Proline Mutant Of Neural Cadherin
… are calcium dependent glycoproteins whose homophilic interactions mediate cell-cell adhesion in solid tissues. They are comprised of an extracellular region, a transmembrane region and a cytoplasmic region. The extracellular region plays a critical role in cadherin-mediated cell adhesion, …
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The Voltage Gated Sodium Channel β1/β1B subunits: Emerging Therapeutic Targets in the Heart
… βadp1 initially disrupts β1-mediated trans-homophilic adhesion, but after approximately 30 hours eventually increases adhesion. Novel mimetic dimers increase β1 adhesion up to 48 hours post-treatment. Furthermore, it appears that βadp1 may increase β1 adhesion by upregulating the …
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Biophysical and Structural Studies of CNTNAP2
… presynaptic and postsynaptic membranes through homophilic and heterophilic interactions promoting synapse development, function, and plasticity. The synaptic adhesion molecules contactin 2 (CNTN2), and contactin associated protein-like 2 (CNTNAP2) have an emerging role at synaptic interaction …
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Kinetics and regulation of the initial stages of cadherin-mediated adhesion
… interactions between cadherins of the same type (homophilic), and cadherins of different types (heterophilic) are quantified. The affinity changes are then correlated with cell aggregation results, demonstrating the threshold of affinity change required to see cells segregate. Multiple cell types …
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CD166 modulates disease progression and osteolytic disease in multiple myeloma
… immunoglobulin superfamily capable of mediating homophilic interactions, has been shown to enhance metastasis and invasion in several tumors. However, whether CD166 is involved in MM and plays a role in MM progression has not been addressed. We demonstrated that a fraction of all human MM cell …
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Distributed Dynamic Hierarchical Task Assignment for Human-Robot Teams
… study to determine whether humans can form a homophilic relationship with robots and whether there is a connection between homophily and trust. We found a correlation between homophily and trust in human-robot interactions.Furthermore, we designed a pipeline by which the robot learns a task by …
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An Empirical Approach to Social Networks
… a technique called cluster analysis to determine homophilic ties within a single attribute, religiosity. We see that religion affects economic attitudes and activities of individuals, groups, and societies. Further, religion influences how behavior and institutions are affected by social relations …
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Functional Characterization of Protein Tyrosine Phosphatases in Tumorigenesis through Substrate Identification
… the extracellular fragments of PTPRT mediate homophilic cell-cell interactions and that cancer-derived mutations in the MAM, Ig and FN III domains of PTPRT impair cell-cell adhesion, indicating that these PTPRT mutations are loss-of-function mutations.</p> <p>Taken together, these studies …
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