Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"homologous recombination deficiency"”.
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Clinical Significance of Homologous Recombination Deficiency Score Testing In Endometrial Cancer
<p><strong>Objectives: </strong>Homologous recombination deficiency (HRD) score is related to chemotherapy response in breast and ovarian cancers. The role of HRD is unknown in endometrial cancer. We examined the relationship between HRD score and survival in a cohort of endometrial cancer patients …
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SOX2 is Associated with Changes in DNA Damage Repair and Cell Cycle Gene Expression and Regulates E2F1
… the tumor expression profiles score for homologous recombination deficiency is available for patients. However, this is typically only used to determine if Poly (ADP-Ribose) Polymerase (PARP) inhibitors are an appropriate treatment option. One potential biomarker my lab has identified is …
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Genomic aberrations as determinants of immune infiltrates in high grade serous ovarian carcinoma
… of immune cell densities, while the presence of homologous recombination deficiency (HRD)-associated CN signature 7 correlates positively with immune cell abundance (p > 0.05, ANOVA). Samples with a combination of absent CN signature 6 and present CN signature 7 had the highest abundance of …
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The clonal architecture and tumour microenvironment of breast cancers are shaped by neoadjuvant chemotherapy
… with an increase in genomic instability and homologous recombination deficiency during treatment. The immune TME composition and activity mirrored response to treatment, with cytolytic activity and innate and adaptive immune infiltrates linearly correlating with the degree of residual disease …
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Driver genes, mutational signatures and the timing of mutations in oesophageal adenocarcinoma
… enzymatic DNA damage (by the APOBEC enzymes) and homologous recombination deficiency. Two novel signatures dominated the genomes and were seen only very rarely in tumours from other sites. These signatures may represent the action of mutagens in the novel environment found around the oesophagus …
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Exploring mutational signatures in human cancers using human cell line models
… those that are associated with deficiencies in homologous recombination-based repair and mismatch repair. During this process, I have also identified key issues in designing and performing such mutational signature studies, and hence devised a set of guidelines for future experiments and …