Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"homologous recombination (HR) repair"”.
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Nprl2/Tusc4 Functions As A Tumor Suppressor By Regulating Brca1’S Stability Via The E3 Ubiquitination Pathway
… In the present study, we demonstrate through microarray analysis that cells with tumor suppressor candidate 4 (NPRL2/TUSC4) knockdown show critical changes to cell cycle, cell death pathways and a global impact on cancer development. More importantly, we observed a clear cluster pattern …
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Interactions of human and drosophila Rad 51 paralogs
… and cancer. It is therefore essential to repair DNA damage, and to do so a variety of DNA repair mechanisms have evolved. One of the repair mechanisms, known as homologous recombination (HR) repair, uses an undamaged sister chromatid as a template to make error free repairs to …
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FANCD2 in relation to BRCA2 mutated breast cancer
… processes and are required for maintenance of chromosomal stability including DNA homologous recombination (HR) repair and DNA replication support. It has been shown that BRCA2 has an important role in maintaining the stability of chromosomal ends (Bodvarsdottir et al., 2012). It has also been …
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Function of Znf668 In Cancer Development
… <strong>ZNF668 functions as a DNA repair protein by regulating histone acetylation. </strong>DNA repair proteins need to access the chromatin by chromatin modification or remodeling to use DNA template within chromatin. Dynamic posttranslational modifications of histones are …
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Mechanisms of Immunogenic Cell Death in Tumour Cells Infected with Oncolytic Vaccinia Virus
… we focused on the interaction between host DNA-repair capabilities and oVACV infection. We tested whether mutations in the DNA repair proteins DNA-PKcs, BRCA1 or BRCA2 had an impact on oVACV-induced death and found that BCRA2-deficient cells were more sensitive to oVACV killing than their …