Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1086 for “"homologous"”.
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Solvation Energy Calculations of Homologous Trimethylammoniocarboxylates
… The solvation energies were determined for a homologous series of betaines, (CH₃)₃N+(CH₂)nCOO- where n = 1 to 6. Their structure is composed of only the hydrophilic head group of a surfactant. The solvation energies were determined from both the gas phase energy and free energy of solution. …
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Statistical Analysis of Biological Interactions from Homologous Proteins
Information fusion aims to develop intelligent approaches of integrating information from complementary sources, such that a more comprehensive basis is obtained for data analysis and knowledge discovery. Our Protein Biological Unit (ProtBuD) database is the first database that integrated the …
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Catalytic antibodies elicited via homologous and heterologous immunization
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1994.
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5-hydroxymethylcytosine and endonuclease G as regulators of homologous recombination
Homologous recombination (HR) is a necessary biological process for all living organisms, and it is especially important for repairing damaged DNA. Improper HR results in DNA damage-related diseases, notably increased likelihood of cancer when HR regulators, such as the human BRCA1 gene, are …
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Telomere Specific Homologous Recombination in the Alternative Lengthening of Telomeres
… suggests that ALT cells maintain telomeres by homologous recombination (Reddel 2003 for Review). Groundbreaking work by Oliver Bechter demonstrated that ALT cells and telomerase-positive cells show no difference in the rate of general HR. This study fundamentally shaped our current concept of …
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The Role of Two Homologous E3 Ligases In Muscle Physiology
… often remains unknown. FBXL3 and FBXL21 are two homologous E3 ligases that have previously been reported to dictate circadian periodicity, with FBXL3 being the dominant E3 ligase and FBXL21 playing a regulatory role. A recent Yeast Two-Hybrid screen revealed a new shared target of FBXL3 and …
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Determining molecular mechanisms of DNA Non-Homologous End Joining proteins
… 5' hydroxyl groups and abasic sites. Non-homologous end joining (NHEJ) is a major pathway responsible for the repair of these complex breaks. Proteins involved in NHEJ include the Ku 70/80 heterodimer, DNA-PKcs, processing proteins including Artemis and DNA polymerases µ and λ, XRCC4, DNA …
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EXAMINING THE ROLE OF THE XAB2 PROTEIN IN HOMOLOGOUS RECOMBINATION
… or ionizing radiation. For my thesis, I studied homologous recombination (HR), which has two sub-pathways: Homology Directed Repair (HDR) and Single Strand Annealing (SSA). HDR involves strand invasion of a homologous template to prime DNA synthesis; SSA involves annealing of homologous segments …
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Homologous Strand Exchange and DNA Helicase Activities in Plant Mitochondria
<p>Homologous recombination is critical for generating genetic variation in living organisms by exchange and rearrangement of DNA. Most of our knowledge about homologous recombination is limited to processes in bacteria or in eukaryotic nuclei. In E. coli, homologous recombination is dependent on …
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Toxin-membrane interactions of Pasteurella multocida toxin and homologous domains
… AB-type toxin that causes atrophic rhinitis, and homologous domains in other toxins. We address both the N-terminal domain necessary for receptor-mediated endocytosis into the cell, as well as the intracellular membrane localization domain (MLD), which is believed to be necessary to enable proper …
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Diverse outcomes of homologous recombination in the human Y chromosome
… still participate regularly in allelic homologous recombination, the male-specific region of the Y (MSY) - the only haploid portion of the nuclear genome - does not. It does, however, engage in non-allelic homologous recombination. In this thesis, I examine modes and outcomes of …
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INVESTIGATING THE LINK BETWEEN HOMOLOGOUS RECOMBINATION PROTEIN BRCA2 AND DNA METHYLATION
… normal cells. One such repair mechanism involves homologous recombination (HR) proteins BRCA2 which protects DNA replication intermediates from nuclease-mediated degradation. Emerging evidence demonstrates that HR proteins like BRCA2 co-evolved with the cytosine methylation machinery, suggesting a …
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Clinical Significance of Homologous Recombination Deficiency Score Testing In Endometrial Cancer
<p><strong>Objectives: </strong>Homologous recombination deficiency (HRD) score is related to chemotherapy response in breast and ovarian cancers. The role of HRD is unknown in endometrial cancer. We examined the relationship between HRD score and survival in a cohort of endometrial cancer patients …
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Harnessing mutagenic homologous recombination for in vivo targeted mutagenesis by TaGTEAM
… point mutations occur through error-prone homologous recombination (HR) and depend on resectioning and the error prone polymerase Pol(?). We show that HR is error-prone in this context because of DNA damage checkpoint activation and base pair lesions and use this knowledge to shift the …
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A synthesis of a homologous series of aryl mono- and diboronic acids
… material, it was deemed desirable to prepare a homologous series of aryl mono- and diboronic acids</p>
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Homologous Recombination Outcomes of Double-Strand Break- initiated Events in Saccharomyces cerevisiae
<p>Homologous recombination (HR) is responsible for repairing otherwise lethal DNA double-strand breaks (DSBs) using a homologous donor template. The work in this dissertation, using the budding yeast Saccharomyces cerevisiae as a model system, focuses on the effect of the initiating DSB and …
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Computational approaches to modeling the conserved structural core among distantly homologous proteins
Modem techniques in biology have produced sequence data for huge quantities of proteins, and 3-D structural information for a much smaller number of proteins. We introduce several algorithms that make use of the limited available structural information to classify and annotate proteins with …
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Understanding The Roles of Non-Homologous End Joining and P53 After Dna Damage
… that mends DNA double strand breaks is non-homologous end joining (NHEJ). Abrogating the NHEJ pathway leads to an accumulation of DNA damage in the lymphoid system that triggers p53-mediated apoptosis; complete deletion of p53 in this system leads to aggressive lymphomagenesis. Therefore, to …
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Homologous recombination and directed differentiation in medaka ES cells: Development of vector systems
… fast assay of relative cellular activities for homologous recombination versus random integration. In this system, a cell that has undergone a homologous recombination has red cytoplasm, while cell with a nonhomologous recombination possesses a green nucleus. The roles of important DNA-repairing …
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MUPrimer : a tool for finding allele specific PCR-primers for homologous gene sequences
… PCR primers that can discriminate among highly homologous gene sequences. The input target DNA includes of closely related sequences, making this software unique. User inputs include designating a master gene, primer positions, included and excluded regions, product length, primer T[subscript …
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