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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 513 for “"homolog"”.
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Spatial-Temporal Regulation of the Atonal Homolog 1 Gene
Controlled spatio-temporal expression of atonal homolog 1 is necessary for the correct development of the cerebellar granule cells, the dorsal interneuron 1 population, gut goblet cells and the cochlear and vestibular hair cells of mice. The purpose of these studies was to determine how atonal …
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Characterization of the zebrafish zipper interacting protein kinase homolog
… of 6 zebrafish Zipper Interacting Protein Kinase homolog has helped to better understand how changes in cell cytoskeletal elements can lead to changes in cell shape and movement. Zebrafish are ideal model organisms for studying ZIPK because it has been previously shown that zebrafish ZIPK has …
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RNA and protein expression patterns of the Drosophila XRCC2 Homolog
… XRCC3/SpnB, and Rad51 C/SpnD participate in homologous recombination repair. The function of DmRad51 D and DmXRCC2 are unknown. The goal of this project was to elucidate the function ofXRCC2 in Drosophila. RNA interference allowed us to knockdown the function XRCC2 and its possible binding …
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Hledání fysiologického partnera proteinu Ddi2 (DNA damage-inducible protein homolog 2)
Jedním z nejdůležitějších buněčných procesů, a to nejen pro degradaci proteinů, je takzvaný ubikvitin-proteasomový systém. V něm hraje klíčovou úlohu ubikvitin, malý protein s jedinečnou schopností řetězit se. Buněčné proteiny, označené daným ubikvitinovým řetězcem a tím předurčené k degradaci, se …
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The Role of Snail Homolog 1 in Embryonic Stem Cell Differentiation
… the Wnt-dependent transcription factor Snail homolog 1: Snail) is expressed and capable of inducing EMT in differentiating ES cells. In addition to EMT, Snail accelerates differentiation, promotes mesoderm commitment, and restricts markers of primitive ectoderm and epiblast. Snail's impact on …
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Investigating the mechanisms of action of the SNF2-homolog protein Fun30
… (Function unknown now 30) shares sequence homology with the Snf2 family of chromatin remodelling proteins. Here the activities and roles of Fun30 have been investigated further. In this study, Fun30 was found to exist predominantly as a homodimer with an apparent molecular weight of 250 …
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Regulation of the Tubulin Homolog FtsZ in <i>Escherichia coli</i>
<p><em>Escherichia coli</em> is a well-known pathogen, and importantly, a widely used model organism in all fields of biological sciences for cloning, protein purification, and as a model for Gram-negative bacterial species. And yet, researchers do not fully understand how this bacterium replicates …
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Posttranskriptionelle Einflüsse auf die Expression des Transkriptionsfaktors Achaete-Scute Homolog-1 (ASCL1)
Der bHLH-Transkriptionsfaktor Achaete-Scute Homolog-1 (ASCL1, hASH1) hat eine wichtige Funktion während der neuronalen Entwicklung. Er ist von Bedeutung für die Differenzierung bzw. die Subtypspezifizierung von neuronalen Zellen. Jedoch ist über seine direkte Regulation wenig bekannt. In …
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The Role of the X-chromosomal Porcupine Homolog Gene in Mouse Development
WNT ligands are secreted proteins that act as signals between cells. WNTs activate several interconnected signaling pathways that are required for embryonic development as well as tissue homeostasis in adults. The X-chromosomal Porcn gene encodes a membrane-bound O-acyl transferase that is required …
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Regulation of Expression of a Retroviral Transforming Gene and its Cellular Homolog
… identification of the product of a cellular gene homologous to the transforming gene of FSV, and the isolation and characterization of phenotypic revertants of rat cells transformed by FSV. Analysis of the defect of the two ts mutants of FSV revealed that P130 is the transforming protein of FSV …
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Isolation and characterization of CEABF-1, the ABF-1 homolog in C. elegans
… These studies investigate the nematode homolog of ABF-1, CeABF-1, and its potential role in the development of C. elegans. The BLAST Database (http://www.ncbi.nlm.nih.gov) predicted a bHLH protein in C. elegans, located on cosmid ZK682.4, of 170 amino acids with an overall 51% similarity …
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The Mi-2 Homolog Mit1 Actively Positions Nucleosomes Within Heterochromatin to Suppress Transcription
… Address: kevinmcreamer@gmail.com Title: The Mi-2 Homolog Mit1 Actively Positions Nucleosomes within Heterochromatin to Suppress Transcription Degree: Doctor of Philosophy Program (Major): Biomedical Sciences Concentration (Track): Cell Biology and Biochemistry Research Advisor: Janet F. Partridge, …
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Genetic and biochemical analysis of the Drosophila melanogaster homolog of the human SCA2 gene
… the normal cellular function of a SCA2 homolog (Datx2). I have shown that, like its human counterpart, Datx2 encodes a cytoplasmic protein present throughout development in a variety of tissue types, including the nervous system. Loss of Datx2 function in the retina, sensory bristles, …
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Absence of Enhancer of Zeste Homolog 2 Promotes the Progression of KRAS-Driven Pancreatic Ductal Adenocarcinoma
… of the epigenetic regulator Enhancer of Zeste Homologue 2 (EZH2). However, contradictory findings suggest multiple roles for EZH2. The goal of this study was to define EZH2’s contributes to early KRASG12D-driven PDAC. I hypothesized that EZH2 restricts KRASG12D initiation of PDAC in response to …
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Sine Oculis Homeobox Homolog 1 (Six1) Plays A Critical Role In The Progression of Pulmonary Fibrosis.
… such developmental gene, Sine Oculis Homeobox Homolog 1 (Six1), which is a transcription factor that is essential for normal lung morphogenesis <em>in utero</em> that I show to be inappropriately expressed in the AT2 cells in IPF.</p>
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Studies into the structural basis of the DNA uridine endonuclease activity of exonuclease III homolog Mth212
Mth212, ein Exonuclease III Homolog aus dem Archeon Methanothermobacter thermoautotrophicus, kompensiert das Fehlen einer DNA-Uracylglycosylase (UDG), indem es einen einzelstrangbruch auf der 5 -Seite des Uridinrestes in DNA katalysiert. Diese Reaktion ersetzt die Basenexzisions Reparatur (base …
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Biological and biochemical characterization of the extracellular signal-regulated kinase 8 homolog (TbERK8) in Trypanosoma brucei
… The extracellular-signal regulated kinase 8 homolog in T. brucei (TbERK8) is essential for survival in bloodstream form T. brucei. The work in this dissertation involves characterizing this T. brucei MAPK to better understand its biological function and identify small molecules that can …
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Improving Potency and Oral Bioavailability of Spinster Homolog 2 (Spns2) Inhibitor: A Structure-Activity Relationship Study
… campaigns is the transporter protein spinster homolog 2 (Spns2). This protein is responsible for the transport of S1P from intracellular space to extracellular space to interact with its receptors and induce the immune response. Recently, our group has developed several effective inhibitors of …
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Epic Search for the Perfect Partner: MutSgamma Promotes Efficient Meiotic Recombination and Homolog Pairing in Mouse Spermatocytes
… with each generation. For parental chromosomes (homologs) to accurately segregate in meiosis I, they must be physically connected to each other to provide tension across the metaphase plate. Homologs are physically attached together by a product of DNA repair by homologous recombination called …
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