Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"homoeostasis"”.
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Molecular mechanisms of neuronal homoeostasis in vivo
Homeostatic plasticity is important in neurobiology for stabilising neuronal networks in the face of Hebbian forms of synaptic plasticity that are thought to mediate memory storage. Impairment of homeostatic plasticity has also been implicated in neurological diseases such as Rett syndrome and …
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Critical roles of nardilysin in the maintenance of body temperature homoeostasis
… in the maintenance of body temperature homoeostasis" Nature Communications 5, Article number: 3224 doi:10.1038/ncomms4224
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Agent Based Modelling of Auxin Transport Canalisation
… of additional localisation hypotheses, or auxin homoeostasis in cells.
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Annexin A5-Conjugated Polymeric Micelles For Dual Spect and Optical Detection of Apoptosis
… a form of programmed cell death, is critical to homoeostasis, normal development, and physiology. Dysregulation of apoptosis can lead to the accumulation of unwanted cells, such as occurs in cancer, and the removal of needed cells or disorders of normal tissues, such as heart, neurodegenerative, …
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Regulatory and self-protection implications of gliotoxin bisthiomethylation in Aspergillus fumigatus
… through the characterisation of changes in SAM homoeostasis within A. fumigatus, this work also illuminates a direct link between gliotoxin biosynthesis and primary metabolic processes. Recombinant GtmA was shown to bismethylate dithiol GT using S-adenosyl methionine (SAM) as a methyl donor. …
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Characterising Triflupromazine as a potential agent to treat glioblastoma multiforme
… Triflupromazine induces a dysregulation in lipid homoeostasis leading to the build-up of cholesterol and various lipid species and inducing necroptosis as a mode of cell death. I propose additional key players in the polypharmacology of Triflupromazine and a novel role for ceramide in the induced …
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Characterisation of Local Mechanical Properties in Living Tissues
… stress relaxation and contributes to tissue homoeostasis.
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Regional Lysosomal Malfunction Underlies the Selectivity of α-Synuclein Neurodegeneration
Dysfunction of protein homoeostasis has been implicated in the pathogenesis of a diverse array of neurodegenerative disorders. However, each neurodegenerative disease is characterized by the accumulation of particular proteins in select regions of the brain. It remains unclear how dysfunction of a …
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Detecting subclinical anthracycline therapy related cardiac dysfunction in low income country (SATRACD study)
… health through altering patients' lipid homoeostasis. This PhD project aims to describe the incidence and predictors of subclinical ATRCD, assess the accuracy of simple echocardiographic parameters on detecting subclinical ATRCD and investigate the lipoprotein subfractions change after …
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From detection of proteasomal degradation to targeted control of protein depletion
… playing an important role in maintaining protein homoeostasis in eukaryotic cells. The UPS has emerged as a drug target for diverse diseases characterized by altered protein homeostasis. However, while proteasome inhibitors are widely used in research and have transitioned to clinical settings, …
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Biological activity of anthocyanins and their phenolic degradation products and metabolites in human vascular endothelial cells
… preserving NO bioavailability and vascular homoeostasis, and this pathway should be the focus of future research.
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Quantifying expression variability in single-cell RNA sequencing data
… a driving role in mammalian development, tissue homoeostasis and immune function. While expression heterogeneity, a phenotypic readout of transcriptional noise, has been broadly studied in prokaryotic model systems or by profiling individual genes, few whole-transcriptome studies in mammalian …
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Large-scale inference and imputation for multi-tissue gene expression
… mechanisms that drive disease and characterise homoeostasis. Effective multi-tissue omics integration promises a system-wide view of human physiology, with potential to shed light on intra- and multi-tissue molecular phenomena, but faces many complexities arising from the intricacies of …
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Synthesising executable gene regulatory networks in haematopoiesis from single-cell gene expression data
… in the mammalian embryo, and maintain homoeostasis in the adult. The cell fate decisions underlying these processes are ultimately made at the level of individual cells. Recent experimental advances in biology allow researchers to obtain gene expression profiles at single-cell …
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Effects of system complexity on protein aggregation in neurodegeneration
… across different components of cellular homoeostasis, in particular lipid membranes and the proteostasis network. In the first chapter of the thesis, I will present a selection of the scientific literature on AD, with a particular focus on systemic aspects, such as cellular networks of …
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The role of hydrodynamic forces in synchronisation and alignment of mammalian motile cilia
… fluid circulation necessary for brain homoeostasis, toxin washout and orientation of the migration of newborn neurons. Despite the fundamental role in nature, the mechanism underpinning such collective behaviour is still unknown. A recent hypothesis, supported by simulations, …
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Immune biomarkers of clinical outcome in patients with major trauma
… responses (SIRS and CARS). The desired outcome, homoeostasis, is the resultant balance between the two opposing arms of the immune response. It is postulated that tissue damage due to over-activity of the SIRS response and immune-paresis due to over-activity of the CARS response render patients …
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Modulatorische Effekte von Stickstoffmonoxid und Juvenilhormon auf die Kontrolle des Reproduktionsverhaltens in weiblichen Chorthippus biguttulus
Sowohl Juvenilhormon (JH) als auch Stickstoffmonoxid (NO) beeinflussen das reproduktive Verhalten weiblicher Heuschrecken. Die vorliegende Arbeit untersucht eine mögliche Verbindung zwischen JH und NO Signalen bei der Kontrolle des weiblichen Paarungsverhaltens in der Heuschrecke Chorthippus …
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MAPK and pro-inflammatory mediators in the walls of brain blood vessels following cerebral ischemia
… of energy depletion, there is disruption of ion homoeostasis, excessive release of excitatory neurotransmitters such as glutamate, calcium channel dysfunction, generation of oxidative stress and free radicals, activation of stress signaling, cell membrane disruption, inflammation, ultimately …