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Showing 1 to 7 of 7 for “"homobifunctional"”.
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Covalent coupling of growth factors to collagen matrices: a novel development towards a tissue substitute with enhanced angiogenesis
… bound to collagen sponges by means of the homobifunctional cross-linking agent bis-(succinimidyl succinate) polyethylene glycol (SS-PEG3400-SS), after coupling activity can then be compared with control experiments in which the VEGF was simply admixed. In order to prevent rapid degradation, …
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A 'Toolkit' of Small Molecules for Polymer Assembly and Post-Synthetic Modification Using 'Click' and Photoactive Chemistries
… the synthesis of several second-generation homobifunctional exogenous photocrosslinkers that extend upon previous work from our group. Additionally, a first-generation crosslinker is used to core-crosslink micellar aggregates of block copolymers. Chapter 3 describes the design, synthesis, …
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Fiber Reactive Dyes with Improved Affinity and Fixation Efficiency
… corresponding Teegafix structures. The resultant homobifunctional dyes vary in molecular size and reactivity and are designed to enhance dye-fiber fixation efficiency and affinity. In this study, the affinity of the new structures has been assessed using equilibrium exhaustion and dyeing …
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Untersuchungen zur Modifikation der Oberfläche und des Porensystems eines porösen Knochenersatzwerkstoffes aus TiO 2/Glas-Kompositkeramik
… factor BMP-2, respectively, using a homobifunctional crosslinker with a polyethylene glycol spacer. A fraction of 60% of the totally bound protein was adsorbed on Ecopore in both cases. In vitro studies revealed that human osteoblasts showed a better spreading and proliferation on …
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Bioenergetic coupling in P-glycoprotein: determining the relative position, topography and role of transmembrane helices six and twelve
… using intramolecular cross-linking with homobifunctional reagents and 5 double resonance EPR. Further ATP hydrolysis assays were used to determine the effect of intramolecular cross-linking between TM6 & 12 on the activity of P-gp. All the double mutants were functional, and most …
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Bioenergetic coupling in P-glycoprotein: determining the relative position, topography and role of transmembrane helices six and twelve
… using intramolecular cross-linking with homobifunctional reagents and 5 double resonance EPR. Further ATP hydrolysis assays were used to determine the effect of intramolecular cross-linking between TM6 & 12 on the activity of P-gp. All the double mutants were functional, and most …
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Computational methods and machine learning for crosslinking mass spectrometry data analysis
… applying a standard crosslinking approach using homobifunctional NHS-ester crosslinker reagents, an exhaustive peptide identification strategy becomes quickly unfeasible because of the dynamic explosion of the search space. Therefore, robust heuristics are needed to make the identification of …