Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"homeostatic plasticity"”.
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Activity-dependent regulation of GIRK and Kv7 channels in homeostatic plasticity and epilepsy
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-15 without embargo terms
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Molecular mechanisms of neuronal homoeostasis in vivo
Homeostatic plasticity is important in neurobiology for stabilising neuronal networks in the face of Hebbian forms of synaptic plasticity that are thought to mediate memory storage. Impairment of homeostatic plasticity has also been implicated in neurological diseases such as Rett syndrome and …
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Activity-Dependent Regulation of Inhibition from Different Inhibitory Subtypes
… on a time scale of hours to days is known as homeostatic plasticity. At the simplest level, homeostatic adaptations occur to maintain firing rate of neurons at a particular set-point. To better understand homeostatic plasticity at the network level, one must understand the activity-dependent …
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The role of Polo-like kinase 2 in synaptic function and plasticity
Homeostatic forms of plasticity keep the spiking output of neurons within an optimal range in the face of changing activity levels of the surrounding network, but little is known about the underlying molecular mechanisms, particularly during heightened activity. We report in Chapter 2 that in …
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Homeostatic adaptive networks
… view of homeostasis and develop a theory of homeostatic adaptive systems. We study homeostatic adaptive networks by looking at specific examples of homeo-static systems: the Homeostat, homeostatic plasticity in neural networks, and homeostatic regulation of the environment by the biota. …
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Regulation of voltage-gated K+ currents in motor neurons: activity-dependence and neuromodulation
… as locomotion and digestion. At the same time, plasticity of neuronal excitability driven by previous experience requires mechanisms to promote stability to maintain physiological function, and many examples of this type of homeostatic plasticity changes have been reported. At the same time, …
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Characterisation of new regulators and neural plasticity of the O2-sensing circuit in Caenorhabditis elegans
… Reminiscent of how sensory deprivation induces homeostatic plasticity, we propose that, in sensory defective mutants, similar mechanisms might sensitise ADL to incoming activity from the O2-circuit and promote O2-escape behaviour. Moreover, we also investigate the extent to which prolonged …
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Molecular tuning of a neural circuit that drives aggregation behaviour in C. elegans
… reflect a widespread requirement for controlling homeostatic plasticity. Two translation factors that have been shown to be dispensable for general translation are important for regulation of the response to stress. Our study raises the possibility that their role in promoting the activity of all, …
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Investigating the Role of Drosophila Tomosyn in Synaptic Strength and Plasticity
… and modulating presynaptic release during plasticity. Chapter 2 focuses on the decoy SNARE protein Tomosyn and its role at the Drosophila larval neuromuscular junction (NMJ). Larval muscles are typically co-innervated by two glutamatergic motoneurons (Ib and Is) that show highly stereotyped …
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Activity-Dependent Plasticity in the Murine Olfactory Bulb Neurons
… circuit. In sensory systems, adaptive neuronal plasticity is recruited to combat dynamic changes in sensory input – such as its sudden loss - and maintain circuit homeostasis. Adaptive neuronal plasticity can be induced and expressed at different cellular spatial scales, and is heavily modulated …
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Plasticity of the cortical representation of finger extensors induced by paired associative stimulation
This dissertation first explored associative plasticity of the human motor cortical representation with the use of noninvasive transcranial magnetic stimulation (TMS) paired with peripheral electrical stimulation. Paired Associative Stimulation (PAS) has grown in popularity because of its potential …
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Stimulus parameters influencing cortical responses by transcranial magnetic stimulation targeting I-wave dynamics : duration, intensity and interval between interventions
… (TMS) modulates corticomotor excitability and plasticity; however, the magnitude of the effects appears to depend on a range of stimulus parameters. Three possible critical factors of repetitive TMS (rTMS) interventions are the duration of application, the intensity of the stimulation and the …