Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"homeodomain protein"”.
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Coordinate regulation of Vegf signalling genes by the proline rich homeodomain protein
… receptor signalling. CK2 is a stress-activated protein kinase with pleiotropic activity and CK2 phosphorylation of PRH inhibits its DNA binding activity. Here I show that CK2 can antagonise PRH induced cell death and transcriptional regulation. Furthermore I show that CK2 reduces PRH stability …
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Components Required for the Death and Degradation of the Linker Cell in C. Elegans
… functions, in part, through the stressrelated protein HSF-1, and subsequent upregulation of members of the ubiquitin proteasome system. How exactly HSF-1 is post-translationally regulated to either commit to cell survival or cell death is not currently known. Using a protein interaction screen …
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WHO: A Novel Wuschel-Like Homeodomain Transcription Factor in Arabidopsis
We have isolated a novel homeodomain transcription factor gene in Arabidopsis. It shares a high degree of identity with WUSCHEL (WUS), a transcription factor involved in specifying stem cell fate in shoot and floral meristems among several plant species. This novel homeobox gene, designated as …
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Cryo-electron microscopy studies of pluripotency factor Nanog
… which includes Nanog, Sox2 and Oct4. Nanog is a homeodomain protein which, when over-expressed, can drive cytokine-independent self-renewal of undifferentiated ES cells. Dimerisation of Nanog through the tryptophan repeat (WR) region, a low complexity domain including 10 tryptophan residues, has …
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Developing High Purity Embryonic Stem Cell-Derived V2a Interneurons for In Vitro Investigation and Transplantation Following Spinal Cord Injury
… population that is defined by expression of the homeodomain protein Chx10 during development. Using CRISPR/Cas9-mediated homologous recombineering, we generated a transgenic mouse embryonic stem cell (ESC) line that enabled us to positively select for Chx10+ ESC-derived V2a interneurons …
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Chromatin and transcriptional regulators act in a cascade to establish a bilateral asymmetry of the C. elegans nervous system
… cell. We identified that a C. elegans Otx homeodomain protein CEH-36 and two basic helix-loop-helix proteins NGN-1 and HLH-2 promote the generation of the MI neuron and are required to establish the bilateral asymmetry in this cell lineage. We found that CEH-36 is asymmetrically expressed …