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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 72 for “"homeodomain"”.
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Characterising GIGANTEA interactors: the BELL-LIKE HOMEODOMAIN 3 and BELL-LIKE HOMEODOMAIN 10 proteins
… interacted with GI. Previously, the BELL-LIKE HOMEODOMAIN 3 (BLH3) protein was identified as a putative GI protein interactor. As part of this thesis work, yeast 2-hybrid and in vitro pull down assays were utilised to confirm the interaction between GI and BLH3. Sequence and phylogenetic …
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Investigation of Interactions between Homeodomain Proteins and DNA
In dieser Arbeit wurden spektroskopische und reaktionskinetische Methoden angewandt, um die Wechselwirkungen zwischen Homeodomän-Proteinen und DNA zu studieren. Die Untersuchung der intrinsischen Fluoreszenz und des Circulardichroismus von Bicoid- (Bcd), Ultrabithorax- (Ubx) und Engrailed- (En) …
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Side chain mobility and hydration in homeodomain-DNA recognition
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1998.
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WHO: A Novel Wuschel-Like Homeodomain Transcription Factor in Arabidopsis
We have isolated a novel homeodomain transcription factor gene in Arabidopsis. It shares a high degree of identity with WUSCHEL (WUS), a transcription factor involved in specifying stem cell fate in shoot and floral meristems among several plant species. This novel homeobox gene, designated as …
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The engrailed homeodomain : determinants of DNA-binding affinity and specificity
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1995.
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Functional specificity and design of transcription factor : the Oct-1 homeodomain
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1995.
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Coordinate regulation of Vegf signalling genes by the proline rich homeodomain protein
PRH is a transcriptional repressor that regulates development of the haematopoietic and vascular systems. VEGF is a mitogen that stimulates cell survival via cell surface receptors including VEGFR1 and VEGFR2. This thesis identifies Vegf, Vegfr1, and Vegfr2 as bona fide PRH target genes and shows …
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Novel Mechanisms of Transcriptional Repression by the Paired-like Homeodomain Transcription Factor Goosecoid
… in gastrulation. Among these are the paired-like homeodomain transcription factors Goosecoid (Gsc) and Mixl1. At the molecular level, Gsc has been described to function as a transcriptional repressor by directly binding to paired homedomain binding sites on target promoters. Here, I describe a …
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Protein-DNA Recognition Models for the Homeodomain and C2H2 Zinc Finger Transcription Factor Families
… factor families are the zf-C2H2 and homeodomain TF families. Newly available PBM and B1H specificity models were used to develop recognition models for these two families, with the goal of being able to predict the binding specific of a TF from its protein sequence. We developed a …
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Analysis of Plant Homeodomain Proteins and the Inhibitor of Growth Family Proteins in Arabidopsis thaliana
… closed status of chromatin. The PHD (Plant HomeoDomain) finger is a structural domain primarily found in nuclear proteins across eukaryotes. This domain specifically recognizes the epigenetic marks H3K4me2 and H3K4me3, which are di- and tri-methylated lysine 4 residues of Histone H3 (Loewith …
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Plant Homeodomain Finger Protein 20 (Phf20) and Its Homolog Phf20 Like 1 (Phf20L1) Define Two Distinct Non-Specific Lethal (Nsl) Complexes
<p>Plant Homeodomain Finger Protein 20 (PHF20) and its homolog PHF20 Like 1 (PHF20L1) are known subunits of the Non-Specific Lethal (NSL) complex, which acetylates lysine residues on histone H4 and regulates gene expression. The current model assumes that PHF20 and PHF20L1 are present together in …
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Biophysical Analyses of Intermolecular Ion-Pairs in Protein-DNA Complexes
… side chain dynamics of the Antennapedia homeodomain (Antp) for both lysine and arginine side chains. Using NMR spectroscopy, we determine the mobility of lysine and arginine side chains in the free and DNA-bound state of Anp through 15N relaxation experiments. We show that side chain …
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Investigating the role of gene duplication in the evolution and divergence of Arachnids
… two Hox clusters and approximately 40% of other homeodomain containing genes. This supports the finding that there was a whole genome duplication (WGD) event in the common ancestor of these animals (Arachnopulmonata) that is not found in outgroups like ticks, mites and harvestmen. Studies of …
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Bioinformatics Investigation on the Role of Obox Gene Family in Preimplantation Embryo Development
… we identified Obox gene family and encoded the homeodomain-containing transcription factors. Accumulating evidence suggests that homeodomain genes play essential roles in early embryonic development. To investigate whether Obox family has similar roles, we comprehensively analyzed their …
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Molecular analysis of transcriptional properties of Pbx1 and E2a-Pbx1
… of E2a with those encoding the carboxyterminal homeodomain of Pbx1, which binds 5’-TGAT-3’ (3’-ATCA-5’) elements. While E2a-Pbx1 can activate transcription through homodimer elements (TGATTGAT) or through heterodimer elements (e.g. TGATTAAT) with Hox proteins in transcription reporter …
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Cryo-electron microscopy studies of pluripotency factor Nanog
… which includes Nanog, Sox2 and Oct4. Nanog is a homeodomain protein which, when over-expressed, can drive cytokine-independent self-renewal of undifferentiated ES cells. Dimerisation of Nanog through the tryptophan repeat (WR) region, a low complexity domain including 10 tryptophan residues, has …
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A Genetic Test of a Model for Two Activities of Fushi Tarazu Protein in Drosophila Melanogaster
… segmentation gene fushi tarazu (ftz) encodes a homeodomain (HD)-containing protein involved in the establishment of even-numbered parasegments during embryonic development. The D. melanogaster ftz is a derived homeotic selector (Hox) gene which lost its homeotic function during the evolution of …
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The Influence of DNA Methylation on Both H2A.Z Nucleosome Dynamics and the Zinc Finger and Homeoboxes Transcription Factor Family
… The ZHX proteins are an enigmatic group of homeodomain (HD) proteins characterized by the presence of two N-terminal C2H2 zinc fingers followed by four to five tandem HDs. This family has largely been viewed as repressive factors, preventing gene transcription through inhibition of the …
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Hox Targeting in Vertebrate Forelimb Induction: Expression and Comparative Genomics
… vertebrates. Potential Hox, Box-associated, and homeodomain core binding sites in genes inducing the forelimb (<em>Tbx5, Salli, Sall4, and Fgf10</em>) have been predicted through comparative genomics, including the use of sequence alignment, phylogenetic footprinting, and related analyses. We …
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PHF6 modulates the chromatin landscape in B-cell leukemia
… Here, we describe the function of the Plant Homeodomain Finger Protein 6 (PHF6) in leukemia and define its role in regulating chromatin accessibility to lineage-specific transcription factors. We show that loss of Phf6 in B-cell leukemia results in systematic changes in gene expression via …
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