Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 70 for “"homeobox"”.
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Homeobox gene and microRNA duplication in Chelicerata
… and insights to these possible WGD events, homeobox genes and microRNAs (miRNAs) were systematically identified and characterised in chelicerates with evidence for WGDs as well as lineages with no data supporting WGD. The identified pervasive duplication of homeobox genes and miRNAs in …
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The isolation and characterization of a P. Angulosus homeobox
… of this thesis was to isolate and characterize a homeobox-containing gene of the South African sea urchin Parechinus angulosus. This was achieved by constructing a genomic library of several individuals and screening this library using a probe containing the Antennapedia homeobox. Eight clones …
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Role of Msx homeobox genes in uterus during embryo implantation
… work investigates the critical role of Msx homeobox genes in the uterus during embryo implantation. The mammalian Msx homeobox genes, Msx1 and Msx2, encode transcription factors that control organogenesis and tissue interactions during embryonic development. Uterine specific deletion of Msx1 …
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Downregulation of reproductive homeobox gene 6 (RHOX6) interferes with male germ cell differentiation
… contain a 60 amino acid DNA binding motif called homeobox that regulates a variety of developmental events. Recently, a novel cluster of homeobox genes has been discovered on the X chromosome of the mouse. Because of their selective expression in reproductive organs, they are named Reproductive …
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The Role and Mechanism of The Homeobox Gene Hoxa9 In The Growth of Epithelial Ovarian Cancer
… are poorly understood. <em>HOXA9</em>, a homeobox gene that is normally expressed in the developing female reproductive tract, is aberrantly expressed in EOCs and controls the morphologic features of these tumors. The differentiation pattern of a tumor is an important determinant of its …
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Sine Oculis Homeobox Homolog 1 (Six1) Plays A Critical Role In The Progression of Pulmonary Fibrosis.
… one such developmental gene, Sine Oculis Homeobox Homolog 1 (Six1), which is a transcription factor that is essential for normal lung morphogenesis <em>in utero</em> that I show to be inappropriately expressed in the AT2 cells in IPF.</p>
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Functions of The Homeobox Gene Dlx4 In Controlling Inflammatory Signaling and Metastasis of Epithelial Ovarian Cancer
… treatment of advanced stage disease. The homeobox gene <em>DLX4 </em>encodes a transcription factor that is absent from most normal adult tissues. Previous studies from our laboratory have identified that DLX4 is highly expressed in advanced stage EOC and is strongly associated with …
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The Role and Mechanism of The Homeobox Gene Dlx4 In Transforming Growth Factor-B Resistance In Cancer
… The transcription factor encoded by the homeobox patterning gene <em>DLX4</em> is overexpressed in a wide range of malignancies. In this study, I demonstrated that DLX4 blocks the anti-proliferative effect of TGF-b by disabling key transcriptional control mechanisms of the TGF-b …
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Transkriptionelle Regulation des Homeo-Domänen-Transkriptionsfaktors Islet/Duodenum Homeobox-1 (IDX-1) in insulinproduzierenden Betazellen des endokrinen Pankreas
Die Betazellmasse wird durch Apoptose, Proliferation und Neogenese aus Vorläuferzellen an den Bedarf des Organismus angepasst. Fehlregulationen und Verlust der Anpassungsfähigkeit sind Ursachen für Diabetes mellitus Typ-2. IDX-1 ist sowohl ein Hauptentwicklungsfaktor des embryonalen Pankreas als …
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Unravelling the Origins and Evolution of the Animal Kingdom using Genomics
… The same core pipeline was used to extract homeobox gene HGs, a key family usedto understand origin and diversification in animals. Gene trees were inferred from the core datasetHGs to determine the evolution of a gene family iconic in the study of animal body plans. Conservedanimal genes …
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The role of the Fused toes locus containing Iroquois homeobox gene 3, 5, and 6 and Ftm, Fto, and Fts during ovary and testis development in mice
… Fused toes (Ft) locus, which includes six genes: homeobox genes: Irx3, Irx5 and Irx6 and three other genes: Fto, Fts, and Ftm, during male and female gonad development. Ft mutant mice are missing Ft locus genes whose function is unknown during male and female gonad development. These six missing …
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Der Transkriptionsfaktor Hex markiert eine Subpopulation von Endothelzellen bei der Embryonalentwicklung und der Tumorangiogenese
Das Homeobox-Gen Hex reguliert bei Vertebraten eine Vielzahl von Entwicklungsprozessen und steuert dabei die Zellproliferation und Differenzierung. Ziel dieser Arbeit ist es, das Hex-Expressionsmuster sowohl in der Frühphase als auch in späteren Entwicklungsstadien bei Hühnerembryonen zu …
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WHO: A Novel Wuschel-Like Homeodomain Transcription Factor in Arabidopsis
… among several plant species. This novel homeobox gene, designated as W&barbelow;USCHEL-LIKE H&barbelow;OMEOPROTEIN O&barbelow;VEREXPRESSION (WHO), encodes a new WUS-like homeodomain protein of 182 amino acids. There are four single nucleotide polymorphisms found in the Lansberg erecta …
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Nitrilase 2: insight into its regulation in Arabidopsis and its potential for improving maize salt tolerance
… approach was used. Six TFs were identified: HOMEOBOX PROTEIN 34 (AtHB34), HOMEOBOX PROTEIN 24 (AtHB24), HOMEOBOX PROTEIN 28 (AtHB28), HIGH MOBILITY GROUP BOX PROTEIN 9 (AtHMGB9), GLABRA 2 (AtGL2), and SQUAMOSA PROMOTER BINDING PROTEIN-LIKE 7 (AtSPL7). Two of these TFs were further …
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A role for the Spemann organizer gene, Goosecoid, in tumor metastasis
… might be reactivated in tumors. The Goosecoid homeobox transcription factor is a known executer of cell migration from the Spemann organizer. I found that indeed Goosecoid is overexpressed in a majority of human breast tumors. Ectopic expression of Goosecoid in human breast cells generated …
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Characterisation of neural progenitors from the adult retina and ciliary epithelium
… of the mammalian retina. Chx10 is a paired-like homeobox transcription factor gene expressed in the presumptive neural retina of the invaginating optic vesicle. The Chx10 gene is expressed in the proliferating retinal progenitor cell population throughout retinal development hence is one of the …
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The transcription factors Pax-6 and X-dll3 influence visual and olfactory system development in Xenopus laevis
Pax-6 and X-dll3 are homeobox-containing transcription factors that are expressed in developing anterior neural structures in Xenopus. Characterization of multiple Xenopus Pax-6 cDNAs reveals that they fall into four distinct classes. These classes are defined based on the presence or absence of a …
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Identification of the Downstream Effector Genes Involved in HOXB4-Induced Expansion of Hematopoietic Progenitor Cells
<p>Overexpression of HOXB4, a member of Homeobox transcription factor family, promotes expansion of hematopoietic stem and progenitor cells both<em>in vivo </em>and <em>in vitro</em>.<em> </em>However, the molecular mechanisms underlying this effect are not well understood. In order to identify …
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Hox3 duplication and divergence in the Lepidoptera
… cluster of the Lepidoptera, called the Special Homeobox genes. An annotation of this duplicated cluster across a wide number of Lepidoptera was performed in order to assess patterns of duplication and loss across the order. The sequences recovered revealed a large amount of variation associated …
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Effects of the OTX2ECR2 enhancer & PROX1 overexpression in murine retina development
… in the developing retina of the mouse. OTX2 is a homeobox transcription factor important for the development of photoreceptors and bipolar cells. If OTX2 is knocked out, photoreceptors and bipolar cells fail to differentiate. In order for OTX2 to be activated in certain retinal populations, it …
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