Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"hnRNP K"”.
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Heterogeneous Nuclear Ribonucleoprotein K (Hnrnp K) Overexpression and Its Interaction With Runx1 Rna In Acute Myeloid Leukemia
… <p>Here, we identified overexpression of hnRNP K as a recurrent abnormality in a subset (~20%) of AML patients. High levels of this RNA-binding protein associated with inferior clinical outcomes in <em>de novo </em>AML. Thus, to evaluate its putative oncogenic capacity in myeloid disease, …
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A mechanism for SCA10 neurodegeneration due to intronic repeat expansion
… heterogeneous nuclear ribonucleoprotein kinase (hnRNP K), important for basic cellular function, binds the AUUCU expansion in in vitro binding experiments as well as within cell culture and in the brain of SCA10 transgenic animals. The loss of function of hnRNP K is hypothesized to induce SCA10 …
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Defining the Role of Secondary DNA Structures and Transcription Factors on the Transcriptional Control of the HIF-1alpha and VEGF Promoters
… factors heterogeneous nuclear ribonucleoprotein (hnRNP) K and nucleolin, respectively, both in vitro and in vivo and their potential role in the transcriptional control of HIF-1α and VEGF. In this dissertation, we demonstrate that both nucleolin and hnRNP K bind selectively to the G- and C-rich …
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Ribonomic Control During Global Brain Ischemia And Reperfusion
… CA1, but absent from control CA1. AUF-1, hnRNP K, hnRNP M were also absent from control CA1 following Hu protein immunoprecipitation and Western blot, suggesting that HuB bound AUF-1, hnRNP K, hnRNP M in all experimental groups except control CA1.</p> <p>2. mRNA populations were different …
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Investigation of Vesicular Stomatitis Virus Interaction with Host Cell Proteins and Associated mRNA Structures
… heterogeneous nuclear ribonucleoproteins (hnRNPs), relocalized from the nucleus to the cytoplasm during infection with VSV. We performed co-immunoprecipitation and RNA-seq experiments to identify and quantify the RNAs that interacted with hnRNP A1, hnRNP C1/C2, and hnRNP K during normal …
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Identification des éléments CIS d'ARN et développement d'un gène rapporteur pour caractériser les facteurs d'épissage qui contrôlent l'expression du facteur de transcription pro-apoptotique TAF6[delta]
… liaison pour les protéines de liaison à l’ADN, hnRNP K et H respectivement. Nous avons donc testé l’effet de la surexpression de hnRNP K et H sur l’épissage alternatif de TAF6 et nous n'avons eu aucuns changement sur l’expression de TAF6ð endogène. De plus, nous avons constaté que la mutation …
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Posttranskriptionelle Einflüsse auf die Expression des Transkriptionsfaktors Achaete-Scute Homolog-1 (ASCL1)
… das heterogene nukleäre Ribonukleoprotein E1 (hnRNP-E1) und das heterogene nukleäre Ribonukleoprotein K (hnRNP-K), welche schon mit der Stilllegung der Translation von bestimmten mRNAs beschrieben wurden. Diese reversible translationale Stilllegung von hASH1 ist möglicherweise ein Anzeichen …
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Structure and Function of KH Domain in DDX43 and DDX53 Cancer Antigen Helicases
… human heterogeneous nuclear ribonucleoprotein K (hnRNP K). The typical function of KH domain is to bind single-stranded (ss) RNA or ssDNA in a sequence specific manner. The helicase core domain contains two conserved RecA-like domains and unwinds double-strand nucleic acids in a …
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Identification of Loss of Specific FMRP-RNA Interactions as a Cause of Fragile X Syndrome
… in one of the RNA-binding domains of FMRP, hnRNP K homology (KH-type) domain 2. This I304N mutation has previously been shown to abrogate RNA binding. We generated and analyzed mouse models harboring the I304N mutation. The mutant protein retains some normal activities, as it is competent to …
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Régulation de l'épissage alternatif du gène apoptotique bcl-x
… Au début, j'ai aidé à l'identification des hnRNP F et H qui lient une région riche en guanidine, nommée B2G, présente dans l'exon alternatif. Ces protéines lient cet élément et ainsi augmenterait la formation de l'isoforme Bcl-x[indice inférieur s]. Ces résultats sont présentés en annexe. …
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The c-Myc/TBX3/nucleolin/Hsc70 signalling axis in breast cancer
… list three partners viz nucleolin, Hsc70 and HnRNP K were validated by immunoprecipitation and colocalization experiments. Importantly, results show that the interaction of TBX3 with Hsc70 is required for TBX3 protein stability and that nucleolin and TBX3 cooperate to promote MCF-7 breast …