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Showing 1 to 14 of 14 for “"hnRNP A1"”.
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Role of hnRNP A1 in the Regulation of HDM2 Gene Expression
<p>hnRNP A1 is one of the most abundant and ubiquitously expressed member of hnRNPs (Heterogenous Nuclear Ribonucleoproteins) family of proteins that play multiple roles in gene expression by participating in major steps in the processing of nascent RNA transcripts 1. It is involved in mRNA …
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Interaction entre la protéine HnRNP A1/UP1 et les séquences télomériques humaines
La protéine hnRNP A1 et son dérivé protéolytique UP1 sont en mesure d'augmenter la taille des télomères in vivo. De plus, UP1, mais non A1, peut interagir avec la télomérase (LaBranche et al., 1998). Afin de déterminer si UP1 se lie aux séquences télomériques humaines, des études de liaison par gel …
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Modulation de l'épissage alternatif de hnRNP A1 : éléments de contrôle et mécanismes d'action
… alternatif demeure restreinte. Le gène hnRNP Al encode deux isoformes, A1 et A1<sup>B</sup>, produites respectivement par exclusion et inclusion de l'exon alternatif 7B. La protéine A1, qui représente le prototype de la famille des hnRNP A/B, lie l'ARN et possède la propriété de moduler …
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Regulation of hnRNP A1 Cellular Localization by Protein Kinases and its Biological Impact
… independently of the 5’ m7G cap structure. hnRNP A1 (heterogeneous nuclear ribonucleoprotein A1), a multifunctional RNA binding protein, is required for the IRES-dependent translation of many specific RNAs within the cell cytoplasm. The phosphorylation of hnRNP A1 is required for its …
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Antibodies to Heterogenous Nuclear Ribonucleoprotein A1 Penetrate Neurons Leading to Multiple Downstream Effects Resulting in Neurodegeneration
… to heterogenous nuclear ribonuclearprotein A1 (hnRNP A1), an RNA binding protein (RBP) highly expressed in neurons. hnRNP A1 functions in pre-mRNA splicing, mRNA trafficking, and translation. Furthermore, the anti-hnRNP A1 antibodies are specific to a N-terminal region termed ‘M9’ which …
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Development of Specific Inhibitors that Prevent hnRNPA1-Mediated Therapy Resistance in Small Cell Lung Cancer.
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a diverse family of RNA-binding proteins (RBPs) that are involved in many steps in gene regulation. The hnRNP family consist of 20 members which are expressed in humans (A1 to U). The first member identified being hnRNP A1; this is a …
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Understanding and Targeting the FGF-2/S6K2 Signal Pathway in Small Cell Lung Cancer Towards the Development of Novel Anti-Cancer Treatments.
… protein Heterogeneous Nuclear Ribonucleoprotein A1 (hnRNP A1) at serines 4 and 6. The phosphorylated hnRNP A1 then binds two anti-apoptotic mRNAs, XIAP and Bcl-X L , believably at Internal Ribosome Entry Sites (IRES) in the mRNAs 5‘ Untranslated Regions (UTR). The hnRNP A1-bound mRNAs are then …
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The Effect of Stress Induced Premature Senescence on the Expression of Heterogeneous RibonucleoIeoprotein
… of heterogeneous nuclear ribonucleoproteins (hnRNP) in cellular senescence is yet to be defined. Cellular senescence is a terminal growth arrest in somatic cells. It is thought to be the consequence of telomeric shortening that acts as a DNA damage signal. Conversely, cells induced into …
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Regulation of alternative splicing and its connections to cancer
… by binding sites for the RNA-binding proteins hnRNP A1/A2 and PTB. These proteins bind to exon 9 and repress its inclusion in the mRNA, resulting in PKM2 production. Additionally, we show that hnRNP A1/A2 and PTB are all overexpressed in cancers in a way that precisely correlates with the …
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Characterization of Nuclear Localization Signals of Karyopherin-Mediated Nuclear Import
… (or Transportin) and its well-characterized hnRNP A1-NLS (or M9NLS) reveal that NLSs recognized by Kap beta2 are structurally disordered, have overall positive charges and contain a loose N-terminal hydrophobic or basic motif followed by a C-terminal conserved R/H/KX₍₂₋₅₎PY motif. The newly …
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Investigation of Vesicular Stomatitis Virus Interaction with Host Cell Proteins and Associated mRNA Structures
… heterogeneous nuclear ribonucleoproteins (hnRNPs), relocalized from the nucleus to the cytoplasm during infection with VSV. We performed co-immunoprecipitation and RNA-seq experiments to identify and quantify the RNAs that interacted with hnRNP A1, hnRNP C1/C2, and hnRNP K during normal …
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Studies on mammalian pre-mRNA splicing : connections to transcription and cancer
… by binding sites for the RNA-binding proteins hnRNP A1/A2 and PTB. These proteins bind to exon 9 and repress its inclusion in the mRNA, resulting in PKM2 production. Additionally, we show that hnRNP A1/A2 and PTB are all overexpressed in cancers in a way that precisely correlates with the …
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Molecular Mechanisms of Alternative Splicing Regulation: An Investigation of the Spliceosome Repressed by Hnrnp L on Cd45 Exon 4
… sequence (ESS1) within CD45 exon 4 is bound by hnRNP L to induce its skipping. HnRNP L represses spliceosome assembly at a step after the binding of U1 and U2 snRNP on either side of the exon. My goal is to understand how hnRNP L perturbs U1 snRNP binding at the 5' splice site (5' ss) to cause …
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Structural and Biochmical Studies of Nuclear Import Factor Karyopherin Beta-2
… with its most well studied substrate, the NLS of hnRNP A1 (M9NLS), elucidates the mechanism of substrate release by Ran GTPase. Analyses of the structure in conjunction with available NLS sequences reveal three general rules for NLS recognition by Kapbeta 2: NLSs are structurally disordered in …