Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 45 for “"hnRNP"”.
-
Untersuchungen zum molekularen Pathomechanismus der SMA durch Anaylse der Smn-Interaktionspartner hnRNP-R und hnRNP-Q
… beiden heterogenen nukleären Ribonukleoproteine hnRNP-R und hnRNP-Q als neue SMN-bindende Proteine identifiziert. Diese beiden hochhomologen Proteine waren bereits bekannt und stehen in Verbindung mit dem RNA Metabolismus, im Speziellen: Editing, Transport und Spleißing. hnRNP-R und -Q …
-
Context-Dependent Function of the Splicing Factor hnRNP L
… this mode of regulation, is the human CD45 gene. HnRNP L binds to a motif present in both CD45 variable exons 4 and 5 to affect their coordinate repression. Previously, it was shown that hnRNP L regulates exon 4 by stalling the U1 and U2 snRNPs in a non-permissive A-like exon-defined spliceosomal …
-
Role of hnRNP A1 in the Regulation of HDM2 Gene Expression
<p>hnRNP A1 is one of the most abundant and ubiquitously expressed member of hnRNPs (Heterogenous Nuclear Ribonucleoproteins) family of proteins that play multiple roles in gene expression by participating in major steps in the processing of nascent RNA transcripts 1. It is involved in mRNA …
-
Interaction entre la protéine HnRNP A1/UP1 et les séquences télomériques humaines
La protéine hnRNP A1 et son dérivé protéolytique UP1 sont en mesure d'augmenter la taille des télomères in vivo. De plus, UP1, mais non A1, peut interagir avec la télomérase (LaBranche et al., 1998). Afin de déterminer si UP1 se lie aux séquences télomériques humaines, des études de liaison par gel …
-
Modulation de l'épissage alternatif de hnRNP A1 : éléments de contrôle et mécanismes d'action
… alternatif demeure restreinte. Le gène hnRNP Al encode deux isoformes, A1 et A1<sup>B</sup>, produites respectivement par exclusion et inclusion de l'exon alternatif 7B. La protéine A1, qui représente le prototype de la famille des hnRNP A/B, lie l'ARN et possède la propriété de moduler …
-
Combinatorial Regulation of Signal-Induced CD45 Exon Repression by hnRNP L and PSF
… silencing under resting conditions by binding to hnRNP L. ESS1 is also sufficient to confer the activation-induced increase in exon repression, and this document describes two mechanisms responsible for mediating this effect. First, hnRNP L silencing function is slightly increased in activated …
-
Regulation of hnRNP A1 Cellular Localization by Protein Kinases and its Biological Impact
… independently of the 5’ m7G cap structure. hnRNP A1 (heterogeneous nuclear ribonucleoprotein A1), a multifunctional RNA binding protein, is required for the IRES-dependent translation of many specific RNAs within the cell cytoplasm. The phosphorylation of hnRNP A1 is required for its …
-
Elevated colorectal cancer risk in the hnRNP I knockout mice treated with azoxymethane/dextran sulfate sodium
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-19 without embargo terms
-
Heterogeneous Nuclear Ribonucleoprotein K (Hnrnp K) Overexpression and Its Interaction With Runx1 Rna In Acute Myeloid Leukemia
… <p>Here, we identified overexpression of hnRNP K as a recurrent abnormality in a subset (~20%) of AML patients. High levels of this RNA-binding protein associated with inferior clinical outcomes in <em>de novo </em>AML. Thus, to evaluate its putative oncogenic capacity in myeloid disease, …
-
Antibodies to Heterogenous Nuclear Ribonucleoprotein A1 Penetrate Neurons Leading to Multiple Downstream Effects Resulting in Neurodegeneration
… to heterogenous nuclear ribonuclearprotein A1 (hnRNP A1), an RNA binding protein (RBP) highly expressed in neurons. hnRNP A1 functions in pre-mRNA splicing, mRNA trafficking, and translation. Furthermore, the anti-hnRNP A1 antibodies are specific to a N-terminal region termed ‘M9’ which serves …
-
Molecular Mechanisms of Alternative Splicing Regulation: An Investigation of the Spliceosome Repressed by Hnrnp L on Cd45 Exon 4
… sequence (ESS1) within CD45 exon 4 is bound by hnRNP L to induce its skipping. HnRNP L represses spliceosome assembly at a step after the binding of U1 and U2 snRNP on either side of the exon. My goal is to understand how hnRNP L perturbs U1 snRNP binding at the 5' splice site (5' ss) to cause …
-
The Regulation of the Alternative Splicing of Caspase 9
… and mass spectrometry analysis identified hnRNP L as part of these protein:RNA complexes. Downregulation of hnRNP L induced a significant increase in caspase 9a/caspase 9b mRNA ratio, which translated to the protein level. Expression of hnRNP L verified the siRNA specificity lowering the …
-
Development of Specific Inhibitors that Prevent hnRNPA1-Mediated Therapy Resistance in Small Cell Lung Cancer.
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a diverse family of RNA-binding proteins (RBPs) that are involved in many steps in gene regulation. The hnRNP family consist of 20 members which are expressed in humans (A1 to U). The first member identified being hnRNP A1; this is a …
-
The Effect of Stress Induced Premature Senescence on the Expression of Heterogeneous RibonucleoIeoprotein
… of heterogeneous nuclear ribonucleoproteins (hnRNP) in cellular senescence is yet to be defined. Cellular senescence is a terminal growth arrest in somatic cells. It is thought to be the consequence of telomeric shortening that acts as a DNA damage signal. Conversely, cells induced into …
-
Investigation of Vesicular Stomatitis Virus Interaction with Host Cell Proteins and Associated mRNA Structures
… heterogeneous nuclear ribonucleoproteins (hnRNPs), relocalized from the nucleus to the cytoplasm during infection with VSV. We performed co-immunoprecipitation and RNA-seq experiments to identify and quantify the RNAs that interacted with hnRNP A1, hnRNP C1/C2, and hnRNP K during normal …
-
Understanding and Targeting the FGF-2/S6K2 Signal Pathway in Small Cell Lung Cancer Towards the Development of Novel Anti-Cancer Treatments.
… Heterogeneous Nuclear Ribonucleoprotein A1 (hnRNP A1) at serines 4 and 6. The phosphorylated hnRNP A1 then binds two anti-apoptotic mRNAs, XIAP and Bcl-X L , believably at Internal Ribosome Entry Sites (IRES) in the mRNAs 5‘ Untranslated Regions (UTR). The hnRNP A1-bound mRNAs are then …
-
Aberrant regenerating islet-derived protein 3 (REG3) expression is an early indicator of colonic dysplasia in heterogeneous nuclear ribonucleoprotein (HNRNP I) knockout mice
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01
-
Formation of an Exon-Defined A Complex Spliceosome Intermediate Results in CD45 Exon Repression
… the CD45 gene. ESS1 is bound by at least three hnRNP proteins (hnRNP L, PTB, hnRNP E2) of which hnRNP L is the main functional component. Subsequent work showed that ESS1 does not regulate CD45 exon 4 splicing by the typical mechanism of preventing exon definition. Instead, spliceosome assembly …
-
Regulation of alternative splicing and its connections to cancer
… by binding sites for the RNA-binding proteins hnRNP A1/A2 and PTB. These proteins bind to exon 9 and repress its inclusion in the mRNA, resulting in PKM2 production. Additionally, we show that hnRNP A1/A2 and PTB are all overexpressed in cancers in a way that precisely correlates with the …
Page 1 of 3