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Showing 1 to 18 of 18 for “"histotripsy"”.
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Development of Histotripsy Focused Ultrasound Devices Using Rapid Prototyping Methods
Histotripsy is a nonthermal ultrasound therapy used to treat cancer noninvasively by tissue mechanical fractionation with cavitation bubble clouds. Histotripsy is conducted through focused ultrasound transducers, where the piezoceramic (PZT) plate or disc, which emits the ultrasound wave, is the …
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First-In-DOg HISTotripsy for Intracranial Tumors Trial: The FIDOHIST Study
… ideal model for investigating novel therapies. Histotripsy is a non-thermal ultrasonic ablation method that emulsifies tissue through acoustic cavitation. The primary objectives of this prospective study were to assess the feasibility and safety of histotripsy to ablate naturally occurring …
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Determining the Oncological and Immunological Effects of Histotripsy for Tumor Ablation
Histotripsy is an emerging non-invasive, non-thermal, image-guided cancer ablation modality that has recently been approved for its first clinical trial in the United States (NCT04573881). Histotripsy utilizes focused ultrasound to generate acoustic cavitation within a tumor to mechanically …
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Investigation of Histotripsy Cavitation and Acoustic Droplet Vaporization From Perfluorocarbon Nanoparticles
Histotripsy is a non-invasive and non-thermal focused ultrasound therapy that can be used to ablate tissue within the body while overcoming many of the limitations of thermal ablation. Histotripsy utilizes short-duration, high pressure ultrasound pulses to create a cavitation bubble cloud of …
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Investigation of Advanced Cavitation Agents for Nanoparticle-Mediated Histotripsy (NMH) Applications
Nanoparticle-mediated histotripsy (NMH) is an emergent non-invasive therapy that uses nanoparticles in combination with focused ultrasound with engineered nanoparticles to mechanically ablate targeted tissue with cavitation. Unlike conventional histotripsy, which requires high negative pressures …
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High-Rate Histotripsy Methods for the Rapid Removal of Soft and Fibrous Tissue
Histotripsy is a non-invasive, focused ultrasound ablation modality that uses the precise control of acoustic cavitation to disintegrate tissue. Acoustic cavitation is the transient expansion of pre-existing nuclei to dimensions orders of magnitude beyond their original size due to large increases …
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Characterizing the Effects of Histotripsy for Osteosarcoma Treatment on Tendon Structure and Function
… deleterious effects to surrounding tissues. Histotripsy is a novel limb-salvage technique that can be used to treat OS. Histotripsy is a non-invasive, non-thermal, and non-ionizing focused ultrasound method that mechanically breaks down targeted tissue into subcellular components by …
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Mechanical High-Intensity Focused Ultrasound (Histotripsy) in Dogs with Spontaneously Occurring Soft Tissue Sarcomas
Background: Histotripsy is a non-thermal, non-invasive high-intensity focused ultrasound (HIFU) ablative technique that causes mechanical fragmentation of tissue, resulting in liquefied acellular debris with histologically clear demarcated boundaries between treated and non-treated tissues. The …
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Investigations of Ultrasound-Guided Histotripsy Ablation for Soft Tissue Sarcomas, Osteosarcomas, and Brain Tumors
Histotripsy is a non-thermal, non-invasive focused ultrasound therapy using controlled acoustic cavitation to mechanically disintegrate tissue into an acellular homogenate. Histotripsy applies microsecond-length, high pressure (> 10 MPa) pulses to initiate the rapid expansion and collapse of nuclei …
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Ultrasonic Effervescence: Investigations of the Nucleation and Dynamics of Acoustic Cavitation for Histotripsy-Based Therapies
Histotripsy is a noninvasive mechanical ablation method that uses focused ultrasound to disintegrate target tissues into acellular homogenate through the generation of acoustic cavitation and is currently being developed for numerous clinical applications. Histotripsy uses high-pressure (>10 MPa), …
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Investigations of the Tissue Mechanical Properties and Susceptibility to Histotripsy-Induced Tissue Ablation for Intra-Abdominal Organs
Histotripsy is a non-thermal, non-invasive, focused ultrasound ablation method that uses acoustic cavitation to mechanically break down tissues [1-8]. Histotripsy is heavily dependent on the mechanical properties of the tissue, allowing it to mechanically ablate tissues of lower mechanical …
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Design and Development of Single Element Focused Ultrasound Transducers
Histotripsy is a non-invasive, non-thermal, and non-ionizing therapy that utilizes converging high-pressure ultrasound waves at a focal point to produce cavitation and induce mechanical tissue destruction. Currently, rapid prototyped histotripsy transducers consist of multiple elements and are made …
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Novel Approaches in Pancreatic Cancer Treatment: Bridging Mechanics, Cells, and Immunity
… "cold". This study also investigates the use of histotripsy (a non-thermal, noninvasive, nonionizing ultrasound-guided ablation modality) to treat pancreatic cancer utilizing a novel immunocompromised swine model. We successfully generated human orthotopic pancreatic tumors in the immune …
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Development of an Injectable Hydrogel Platform to Capture and Eradicate Glioblastoma Cells with Chemical and Physical Stimuli
… and 3) assessing the feasibility of utilizing histotripsy to mechanically and non-invasively ablate cells entrapped in the hydrogel. The results revealed that hydrogel formulations comprising 0.175 M NaHCO3(aq) and 50 wt% water content were the most optimal for physical, chemical, and …
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Safety First, Bubbles Second: Integrating Regulatory Compliance with Innovation in Rapid Prototyped Focused Ultrasound Devices
… applications. High-intensity methods, such as histotripsy, introduce safety and performance considerations that may arise during early stages of prototyping. This thesis presents an evaluation framework intended to support early-stage identification of factors related to clinical and regulatory …
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Molecular basis of immunotolerance in canine neoplasia
… molecules in a set of patients that received histotripsy, which is a non-invasive and non-thermal ultrasound focused therapy that induces mechanical stress to the cells, leading to liquefactive necrosis. Here we reported a focal decrease of the expression of these checkpoint molecules in …
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Focused Ultrasound Methods for the treatment of Tendon Injuries
… stimulation. Additionally, feasibility of histotripsy ablation in murine Achilles tendons was successfully investigated ex vivo and in vivo and experimentation to further optimize these methods are ongoing. Such (non-thermal) ablative paradigms will be extremely useful when conservative …
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Detailed simulations of bubble-cluster dynamics
The violent collapse of bubble clusters can be an important mechanism of damage to adjacent material surfaces in both engineering and biomedical applications. Because of their complexity, past theoretical studies have generally been restricted to significantly simplified models, such as homogenized …