Global ETD Search
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Showing 1 to 3 of 3 for “"histone ubiquitylation"”.
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Using "Designer" Nucleosomes to Study Enzymatic Crosstalk Between Histone Ubiquitylation and Histone Methyltransferases
… affecting all types of DNA metabolism. Histone proteins in particular are extensively post-translationally modified (PTM), and many of these individual modifications have been studied in depth. I have been interested in how the complex repertoire of histone PTMs are co-regulated to …
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Sortase-mediated ubiquitylation of Histone H2B and its biological consequences
… the understanding of cell biological processes. Histone 2B (H2B) ubiquitylation has been suggested to collaborate in the complex mechanisms that control the activation or silencing of genes. Here we try to explain how we could use the sortagging technique to control ubiquitylation events inside …
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Identification of a Functional Hotspot on Ubiquitin Required for Stimulation of Methyltransferase Activity on Chromatin
<p>Histone post-translational modifications modulate chromatin structure and function either by directly altering the intrinsic physical properties of the chromatin fiber or by nucleating the recruitment and activity of a host of transacting nuclear factors. Histone ubiquitylation is one class of …