Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"histone reader"”.
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Role of P300 Zz Domain In Chromatin Association and Histone Acetylation
… to bind to chromatin and to acetylate the histone substrates. However, the molecular mechanisms underlying the regulation of these processes are not fully understood.</p> <p>Through combination of various biochemical, biophysical and molecular approaches, we show that the ZZ-type zinc …
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Trim24 As An Oncogene In The Mammary Gland
… acts as a co-regulator of estrogen receptor, a histone reader with tandem PHD and Bromo domains, and a ubiquitin E3-ligase targeting p53 by its RING domain. TRIM24 is over-expressed in human breast cancers, which is correlated with poor patient survival. Previous in cellulo studies in our lab …
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Trim24 Promotes Mammary Tumor Development By Upregulating Metabolic Reducing Power
… for p53, a nuclear receptor co-regulator, and a histone reader. Over expression of TRIM24 correlates with poor overall survival of breast cancer patients. Previously, our lab created a mouse model that conditionally over-expresses (COE) TRIM24 protein in mammary epithelia …
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Trim24 Orchestrates Metabolic Reprogramming and Emt In Breast Cancer
… of nuclear receptors and a PHD/Bromodomain reader of specific histone modifications. TRIM24 expression correlates with poor prognosis of breast cancer, but the mechanisms of TRIM24-mediated oncogenesis are unknown. In the first part of my thesis, I found that TRIM24 is aberrantly expressed …
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Structural Insights into the Mechanisms Controlling the Modification and the Readout of Histone H3.1
The histone H3.1 is the canonical histone H3 inserted into new nucleosomes during replication. The unstructured N-terminal region (also referred to as the tail) of histone H3.1 is decorated by many post-translational modifications (PTMs). These PTMs serve as epigenetic signals coordinating …