Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"histone posttranslational modifications"”.
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HISTONE POSTTRANSLATIONAL MODIFICATIONS AND GENE EXPRESSION IN SACCHAROMYCES CEREVISIAE
Covalent modifications of histones play a critical role in many important biological processes such as transcription, DNA repair and recombination. Among the major modifications known so far, histone H3 acetylation at lysines 9 and 14 (H3K9/14), monoubiquitination of histone H2B at lysine123 …
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A novel computational method for inferring dynamic genetic regulatory trajectories
… the relationship between gene expression and histone posttranslational modifications during motor neuron development. In particular, the trajectories taken by the Hox genes through the space of regulatory states are characterized. Understanding the dynamics of Hox regulation is important …
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PROTEASOME REGULATES TRANSCRIPTION AND TRANSLATION IN LONG-TERM SYNAPTIC PLASTICITY
… blocked transcription-promoting epigenetic histone posttranslational modifications (acetylation, methylation and ubiquitination) and inhibited the upregulation of plasticity-related gene, brain-derived neurotrophic factor (Bdnf). Furthermore, we found a novel non-traditional role of …
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Histone Modifications in Trypanosoma Brucei
… at inactive ES. In other organisms, the role of histone posttranslational modifications (PTMs) in influencing transcriptional states has been well-documented. To begin to understand the role of chromatin structure in the regulation of gene expression in trypanosomes, I developed a protocol for …
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Insights into the molecular mechanisms of function and regulation of histone crotonylation
Histone posttranslational modifications (HPTMs) are major regulators of chromatin dynamics and gene expression. Knowledge about the molecular machineries involved in the regulation and interpretation of a HPTM is crucial for understanding their functional significance. Histone crotonylation is a …
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A role for environmental epigenetics in the rapid diversification of East African cichlid fishes
… these mechanisms include regulation via histone posttranslational modifications, DNA methylation, and non-coding RNAs. By regulating genetic processes in response to external signals, epigenetic mechanisms have an evident role in phenotypic adaptation. Recent explorations have revealed …
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Development of a tool for tracking H3K27 tri-methylation
… that reversibly binds to post-translational modifications to tag the H3K27 trimethylation. Four cell lines were created using a mintbody including super folded GFP that can be induced with treatment with doxycycline. Different numbers of guide RNAs were also used in an attempt to increase …