Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"histone methyltransferases"”.
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Using "Designer" Nucleosomes to Study Enzymatic Crosstalk Between Histone Ubiquitylation and Histone Methyltransferases
… affecting all types of DNA metabolism. Histone proteins in particular are extensively post-translationally modified (PTM), and many of these individual modifications have been studied in depth. I have been interested in how the complex repertoire of histone PTMs are co-regulated to …
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Metabolomic Investigation of Melanoma Metastasis in a Patient-Derived Xenograft Mouse Model
… (TML). TML levels correlated with histone H3 trimethylation at lysines 9 and 27, and methylation at these sites was also enhanced in efficiently metastasizing tumors. Erasing either of these marks by genetically or pharmacologically silencing the histone methyltransferases SETDB1 or …
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MET-2 and SET-25 have sexually dimorphic effects on chromosome structure in Caenorhabditis elegans
… that mutations in different genes involved in histone post-translational modifications have distinct impacts on oocyte and spermatocyte bivalent length. A mutation of set-25, a histone methyltransferase converting histone H3 lysine 9 dimethylation (H3K9me2) to trimethylation (H3K9me3), reduces …
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Developing a novel Drosophila model to study Menin biological function
… transcription through interactions with histone deacetylases, histone methyltransferases, and transcription factors, but its molecular function in neuroendocrine tissues remains incompletely understood. Drosophila melanogaster offers a tractable in vivo platform in which to study Menin …
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Enhancement of death receptor-mediated apoptosis in multiple myeloma cells
… This investigation determined whether the Histone Deacetylase (HDAC) inhibitor SAHA, or inhibitors of the histone methyltransferases G9a and EZH2 (BIX 01294 and GSK343) and Nuclear export inhibitor (NEI) LMB, enhance TRAIL-induced apoptosis and overcome TRAIL resistance in both suspension …
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Release of Histone Lysine Methyltransferases from Rat Brain Chromatin by Nuclease Digestion
<p>The histone lysine methyltransferases catalyze the transfer of methyl groups from S-adenosyl-L-methionine to specific ε-N-lysyl residues in the N-terminal regions of histones H3 and H4. These enzymes are located exclusively within the nucleus and are firmly bound to chromatin. The …
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TMEFF2 is an epigenetic modulator that promotes androgen independent growth in castration-resistant prostate cancer cells
… DNA methylation and the methylation of multiple histone lysines, play significant roles in prostate cancer (PCa). Many histone methyltransferases (HMT) and demethylases (HDM), including the JMJD2 family of histone demethyalses, act as coregulators of AR, and many of these enzymes are implicated …
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Investigation of transcriptional regulation by C. elegans SET-2/SETD1 H3K4 methyltransferase through single-nucleus profiling
… cell. Among these, trimethylation of lysine 4 on histone H3 (H3K4me3), catalyzed by the SETD1 family of histone methyltransferases, is a well-established hallmark of active promoters in eukaryotes. Although loss of SETD1 function results in transcriptional deregulation in many systems, the …
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Paraspeckle protein NONO regulates active chromatin by allosterically stimulating NSD1
… layers of epigenetic control, methylation of histone H3 at lysine 36 (H3K36) and lysine 27 (H3K27) defines euchromatin and facultative heterochromatin, respectively, thereby distinguishing transcriptionally active from repressive chromatin domains. These modifications are catalyzed by distinct …
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Characterization of a Novel Sensing Mechanism Governing Antigenic Variation in P. Falciparum
… epigenetically. The methylation state of histone marks, deposited at active and silent var genes by histone methyltransferases (HMTs), play prominent roles in var gene regulation. Previously, Ukaegbu et al., 2015 showed that manipulating deposition of these marks had a striking impact on …