Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"histone methyltransferase"”.
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Studies on the Histone Methyltransferase G9a
… such mechanism is the association of DNA with histones to form chromatin, the physiological substrate of gene expression. An important means by which histones impact transcriptional activity is through site-specific enzymatic modification of the amino terminal histone "tails", which can alter …
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A C. elegans histone methyltransferase promotes spermatocyte gene expression, spermatid production and fertility
… the tissue-specific expression of all 36 lysine methyltransferase (KMT) genes by endogenous mRNA detection in C. elegans. We found that most KMTs are expressed in only one or two tissues and that the germline is the tissue with the most general KMT expression. We discovered that the …
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MET-2 and SET-25 have sexually dimorphic effects on chromosome structure in Caenorhabditis elegans
… that mutations in different genes involved in histone post-translational modifications have distinct impacts on oocyte and spermatocyte bivalent length. A mutation of set-25, a histone methyltransferase converting histone H3 lysine 9 dimethylation (H3K9me2) to trimethylation (H3K9me3), reduces …
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Gsk3Beta-Mediated Ezh2 Phosphorylation Suppresses Methylation of H3K27 and Ezh2’S Oncogenic Functions
… step. Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase and the enzymatic core subunit of polycomb repressive complex 2 (PRC2), promotes cell growth and migration through catalyzing trimethylation of histone H3 at Lys 27 (H3K27me3) and plays an important role in tumorigenesis. …
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The synthetic multivulva genes and their suppressors regulate opposing cell fates through chromatin remodeling
… complex, which deacetylates lysine nine of histone H3 (H3K9), and HP1, we found two histone methyltransferase (HMT) genes (met-1 and met-2) that act as class B synMuv genes and repress lin-3 transcription. met-1 encodes a C. elegans homolog of yeast Set2, an H3K36 HMT that inhibits the …
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Targeting Epigenetic Regulators For The Treatment of Diffuse Large B-Cell Lymphoma
<p>Small-molecule inhibitors of the histone methyltransferase EZH2 hold great promise for the treatment of Germinal Center B-Cell-like Diffuse Large B-Cell Lymphoma (GCB-DLBCL). Compared to a 60% Objective Response Rate (ORR) in Phase I clinical trials, Phase II trial results for the EZH2 inhibitor …
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The role of MLL4 in the chromatin framework: from the epigenome to 3D genome organization
MLL4 is a histone methyltransferase of the Trithorax (TrxG) group, crucial for maintaining active gene expression by antagonizing Polycomb (PcG) proteins, which enforce repressive states. Proper TrxG-PcG crosstalk is critical for various cellular processes and for determining cell fate. Although …
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Chromatin Regulators of MYC Oncoprotein Activity in Cancer
… the novel interaction of MYC and the G9a histone methyltransferase and demonstrated their coordinated regulation of genome-wide transcriptional repression. This interaction and their resulting gene expression output support breast cancer growth, which is impaired with G9a inhibition. This …
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The Polycomb Complex 2 contributes to developmental delay when histone methylation is inappropriately inherited
<p>Histone methylation is a post-transcriptional modification to the N-terminal tails of histone core proteins that regulates DNA accessibility, and consequently, gene expression. Like DNA, histone methylation can be inherited between generations, and is highly regulated during embryonic …
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Elucidating Purinergic and Pro-inflammatory Signaling Mechanisms in Breast Cancer
… cells. Epigenetic regulation of NF-κB by the histone methyltransferase EZH2 and reciprocal action by the long noncoding RNA NKILA determine cellular response to therapeutic inhibition of NF-κB and EZH2. Thus, this knowledge critically informs the delivery of NF-κB-modulating adjuvants in …
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The Mi-2 Homolog Mit1 Actively Positions Nucleosomes Within Heterochromatin to Suppress Transcription
… and consist of DNA wrapped around an octamer of histone proteins. Nucleosomes can then be modified and spatially arranged to facilitate processes such as transcription, DNA replication, and repair. A special transcriptionally repressive chromatin structure assembles onto gene-poor, repetitive …
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Identification of Novel Core and Accessory Factors Involved in Nucleotide Excision Repair in Yeast
… role of Elc1 in GGR remains unknown. Dot1 is a histone methyltransferase whose sole substrate is histone H3 lysine 79 (H3K79). We identified Dot1 as another GGR-specific factor, as deletion of Dot1 or mutation of H3K79 abolishes GGR, but has no effect on TCR. H3K79 can accept up to 3 methyl …
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Xenoestrogen-Specific Mechanisms of Developmental Reprogramming Correlate With Gene Expression and Tumor Development
… inducedrapid ER signaling, which modifies the histone methyltransferase Enhancer of Zeste homolog 2 (EZH2) via activation of the PI3K/AKT pathway. We further hypothesized that there is a xenostrogen-specific effect on this pathway altering patterns of histone modification, DNA methylation and …
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Deubiquitinating Enzymes Promote Cancer Progression and Metastasis Via Regulating Protein Stability
… the PRC2 complex, silences gene transcription by histone methylation. High levels of EZH2 are a marker of advanced breast cancer and correlate with poor clinical outcomes in many cancers. Although EZH2 enzymatic inhibitors have shown antitumor effects in <em>EZH2</em>-mutated lymphoma and …
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Components of the Ubiquitin Proteasome System are Required for the Nonapoptotic Death of the C. Elegans Linker Cell
… This rise is dependent on an MLL-type histone methyltransferase complex and a MAPK cascade, whose activities are required for linker cell death. The E3 ligase components SIAH-1, RBX-1, and CUL-3 are also required for linker cell death and appear to act in the same pathway as let-70. We …
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Epigenetic Regulation of Muscle Stem and Progenitor Cells
… Important roles for the trithorax H3K4 histone methyltransferase (HMT) MLL1 have been established for early embryogenesis, and for hematopoietic and neural identity. Here, using a conditional Mll1 knockout (KO), we find that in vivo, MLL1 is necessary for efficient muscle regeneration, …
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The Regulation of Cellular Iron Metabolism
… known links to iron homeostasis. SETD2, a histone methyltransferase, was a top hit in the screen, and provides the first example of a chromatin modifying enzyme as a mediator of iron levels. SETD2 depletion leads to an increase in the levels of the cargo receptor NCOA4, responsible for …
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Relationships between chromatin features and genome regulation
… (2) non-sequence, epigenetic factors - histone modifications, TF binding, chromatin remodelling (histone placement, eviction and reconstitution), and non-coding RNA regulation. These factors interact with each other, creating a complex network of interactions. In this thesis I describe …
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The critical role of histone methylation in tumour progression and as anti-cancer targets in neuroblastoma
… regulating the expression of target oncogenes. Histone H3 lysine 79 (H3K79) methylation at Myc-responsive elements of target gene promoters is a strict prerequisites for Myc-induced transcriptional activation. DOT1L is the only known histone methyltransferase that catalyses mono-methylation …
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The Role of the Set1 RNA Polymerase II Interacting Motif (SRIM) in Set1 Recruitment and Histone H3K4 Methylation
… modifications. Among these modifications, histone H3 lysine 4 (H3K4) methylation has been associated with transcription activation. Set1 is the sole H3K4 histone methyltransferase in Saccharomyces cerevisiae and functions in a multi-subunit protein complex (Set1C) to catalyze H3K4 mono-, …
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