Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"histone lactylation"”.
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LINKING HISTONE LACTYLATION TO THE EPIGENETIC REPROGRAMMING OF CD4+ T REGULATORY LYMPHOCYTES IN THE TUMOR ECOSYSTEM
… correlates with a global increase in protein lactylation signal in TI-Tregs isolated from human colorectal and breast tumors and is further enhanced by concomitant exposure to hypoxia. Since we are particularly interested in the role of histone lactylation in Treg cells epigenetic rewiring, we …
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Regulation of Reparative Macrophage Transition by the B-cell Adapter for PI3K (BCAP)
… lactate production. This translates into reduced histone lactylation and decreased expression of reparative macrophage genes. Thus, our results reveal BCAP to be critical cell intrinsic switch that regulates transition of inflammatory macrophages to reparative macrophages by imprinting epigenetic …