Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"histone demethylation"”.
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The role of the chromatin remodeller ISWI in the cellular response to hypoxia
… JmjC family of enzymes are capable of tri-methyl histone demethylation and require molecular oxygen to function making them putative oxygen sensors. Moreover, microarray array data within this thesis confirms that 10 of the JmjC demethylases are up-regulated in U2OS cells when exposed to hypoxia. …
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Investigating genetic and molecular factors contributing to sexual dimorphism in lung disease
… gene transcription, protein translation and histone demethylation. As such, they may specifically regulate pathological processes between males and females. CRISPR-Cas9 knockout cell lines were generated for each candidate gene in male-derived A549 cells. Disease-relevant phenotypes were …
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Crystal Structure and Mechanism of Lysine Specific Demethylase-1
… methylation of specific lysine residues in histone tails is crucial in epigenetic gene regulation. LSD1, the first known lysine-specific demethylase, selectively removes monomethyl and dimethyl, but not trimethyl modifications of Lys4 or Lys9 of histone-3. Here, we present the crystal …