Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"histone deacetylase inhibitor"”.
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Clinical Pharmacology of MS-275, A Histone Deacetylase Inhibitor
… and plasma protein binding of MS-275, a novel histone deacetylase inhibitor, in patients with solid tumors and lymphomas. A validated LC/MS assay was developed to quantitate MS-275 in plasma, human liver microsomes and urine. The pharmacokinetic (PK) evaluation was done using a …
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The Histone Deacetylase Inhibitor, Ms-275, Sensitizes Metastatic Osteosarcoma to Fasl-Induced Cell Death: A Role For C-Flip
… this study was to determine the effects of the histone deacetylase inhibitor, MS-275, on the Fas signaling pathway and susceptibility of osteosarcoma (OS) to Fas ligand (FasL)-induced cell death. OS metastasizes almost exclusively to the lungs. We have shown that Fas expression in OS cells is …
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Part 1 Synthesis of a potent histone deacetylase inhibitor; Part 2 Studies towards a stabilized helix-turn-helix peptide
… of this work describes the synthesis of a new histone deacetylase (HDAC) inhibitor (HDI). HDAC enzymes modify core histones, influence nucleosome structure and change gene transcription by removing the acetyl groups from lysine residues on proteins. HDIs are showing exciting potential as a new …
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Targeting the myofibroblast : new strategies in managing equine corneal fibrosis
… therapies, nanoparticle gene therapy and a histone deacetylase inhibitor, for inhibiting the differentiation of equine corneal fibroblasts into myofibroblasts in vitro. This differentiaion of fibroblast to myofibroblast has been determined to be the major event responsible for corneal …
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Nuclear receptor co-repressor actions in bladder cancer
… with co-treatment with NR ligand and the histone deacetylase inhibitor Suberoylanilide hydroxamic acid (SAHA), resulting in strongly additive anti-proliferative responses to FXR, VDR and PPAR-γ ligands in NCoR1 over-expressing cells; confirmed as a G1/S phase cell cycle arrest in EJ-28. …
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Dynamic histone modifications at the promoters of Hox genes in embryonic stem cells
Histone modifications have been closely associated with changing levels of gene expression, but their role in determining, or possibly predicting, patterns of expression is uncertain. Here, the link between histone modifications and Hoxb gene expression in mouse embryonic stem (ES) cells was …
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Spinal Muscular Atrophy: Evidence of a Multi-System Disease
… of SMA and their therapeutic modulation via the histone deacetylase inhibitor trichostatin A. We also identify dramatic changes in immune organs in mouse models of SMA, which could impact susceptibility to infections. Furthermore, we establish the presence of important defects in fatty acid …
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Chromatin Accessibility Dynamics Underlying Development and Disease
… with myelogenous leukemia cells in response to histone deacetylase inhibitor treatments. In all cases, we coupled these analyses with RNA-seq assays to identify concurrent transcriptional changes. By mapping the changes to these genome-wide signals we defined the contribution of local chromatin …
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MEMORY TH17 CELLS IN THE LUNG DURING SECONDARY BACTERIAL PNEUMONIA FOLLOWING INFLUENZA A VIRUS INFECTION
… Furthermore, we found that an FDA approved histone deacetylase inhibitor (HDACi), Romidepsin (RMD), acts as a novel adjuvant to augment antigen-specific Th17 responses in the lung and improve immunization-induced protection against co-infection. Animals immunized with vaccine adjuvanted with …
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CaV1.3 Ion channel expression and hormone therapy in prostate cancer
… LNCaP cells following treatment with trafficking inhibitor, Brefeldin A and the histone deacetylase inhibitor, sodium butyrate. Overall, the results of this study show that CaV1.3 is relevant to AR-positive and androgen-sensitive PCa and is associated with neuroendocrine differentiation. ENZ …
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Notch Signaling in Neuroblastoma and Renal Cell Carcinoma
… neuroblastoma cells. Here we show that the histone deacetylase inhibitor valproic acid induced differentiation of neuroblastoma cells, in conjunction with activation of Notch-1 signaling. In addition, we also noted that the expression of the Notch target HES-1 was primarily regulated by …
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Romidepsin is a Potential Therapeutic to Treat Metastatic Osteosarcoma
… drug screens, our lab identified romidepsin, a histone deacetylase inhibitor, as a potent inhibitor of viability of highly metastatic osteosarcoma sarcospheres that was non-toxic to normal cells. Romidepsin was additive-to-synergistic with standardof- care chemotherapy and inhibited viability in …
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The Role of the Methyl DNA Binding Domain Protein 2 (MBD2) in Breast Cancer
… in viable tumor cells at equivalent doses of the histone deacetylase inhibitor, SAHA (Vorinostat™), and chemotherapeutic agents Doxorubicin, and Paclitaxel. Stable MBD2 knockdown in MCF7 cells led to an increased proportion of normal epithelial structures in 3D culture (70%, [CI=0.55-0.83]) when …
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Human Organotypic Retinal Cultures as a model of human retinal ganglion cell degeneration in glaucoma. Effects of epigenetic regulation and mesenchymal stem cell derived growth factors.
… survival in long-term HORCs, whereas leukaemia inhibitory factor (LIF) failed to exert this effect. The loss of RGC-derived gene markers expression was selectively altered by the histone deacetylase inhibitor (HDACI) trichostatin A (TSA). Conclusions: The timing for long-term HORCs use ex vivo …
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Induction of Caspase-Dependent Death By Proteasome Targeted Therapy In Glioblastoma
… 14 months with current treatment. The proteasome inhibitor bortezomib (BTZ) shows efficacy in cancers like myeloma, but its clinical utility in other cancer types has been more limited. Newer proteasome inhibitors such as marizomib (MRZ) have unique inhibitory and death inducing properties that …
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Anti-Tumor Effects of The Notch Pathway In Gastrointestinal Stromal Tumors
… Although, the introduction of tyrosine kinase inhibitors has dramatically changed the history of this disease, evidences emerge that inhibition of KIT<em> </em>or PDGFRA are<em> </em>not sufficient to cure patients. The developmental pathway Notch has a critical role in the cell fate, …
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The Roles of Inflammation, Oxidative Stress, and Neurotransmitters in an Animal Model of Post-Traumatic Stress Disorder
… and neuromodulating effects of the histone deacetylase inhibitor (HDACi) valproic acid (VA) on inflammation/oxidative stress and neurotransmitters. Finally, we employed the selective-serotonin reuptake inhibitor (SSRI) sertraline to ascertain why SSRIs have historically been …
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Harnessing DNA nanoarchitecture to overcome immunoevasion in cancer
… used immunotherapies, such as immune checkpoint inhibitors and adoptive cell therapy, aim to overcome the immunosuppressive tumor microenvironment by blocking key regulatory pathways and exogenously activating immune cells. While effective against some cancers, these therapies are still limited …
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The Role of Histone Deacetylases in Cytokine Regulation in Human Gestational Tissues
… their investigation as anticancer drugs, histone deacetylase inhibitors were identified as having anti-inflammatory actions, leading to further studies into how histone deacetylases may be involved in cytokine regulation. However, despite the importance of appropriate histone deacetylase …
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