Global ETD Search
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Showing 1 to 9 of 9 for “"histone chaperones"”.
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Characterisation of the (H3-H4)2-tetramer and its interaction with histone chaperones
Histones are a major protein component of chromatin, yet mechanisms which control synthesis, post translational modification, deposition and removal of histones are not fully understood. Although atomic resolution structures have been solved for the nucleosome core particle, there is limited …
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Regulatory network built by Cytochrome c with Histone Chaperones in response to DNA damage
… such as Protein Phosphatase 2A (PP2A). Moreover, histone chaperones assist the DNA repair mechanisms altering chromatin dynamics through their nucleosome assembly activity. Recent studies have reported that the mitochondrial respiratory protein cytochrome c is promptly translocated into the cell …
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Dissecting Mammalian Replication-Independent Chromatin Assembly — Biochemical and Structural Studies on the H3.3-Specific Histone Chaperones Hira and Daxx
<p>Histones are architectural proteins that wrap approximately two turns of DNA around their octameric core structure, constituting the fundamental packaging unit of eukaryotic chromatin — the nucleosome. Beyond their structural role, they regulate virtually all processes that act on or depend on …
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The structural analysis of histone H3 lysine 56 acetylation and related histone chaperone complexes
… chromatin. Key regulators of these processes are histone binding proteins known as histone chaperones. The histone chaperone complex Chromatin Assembly Factor 1 (CAF-1) is responsible for depositing H3.1/H4 tetramers in a DNA synthesis dependent manner. During replication independent assembly …
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THE INTERPLAY OF HISTONE CHAPERONE NAP1 WITH SWI/SNF FAMILY OF CHROMATIN REMODELLERS IN S.cerevisiae
Histone disassembly is one of the mechanisms by which the ATP dependent chromatin remodelers remodel the nucleosomes. However nucleosome remodeling is also regulated by other factors like covalent modifications marks (methylation, acetylation etc. of both histones and chromatin remodelers). and …
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Investigation of The Roles of Asf1 and Caf-1-Mediated Chromatin Assembly In The Human Dna Damage Response
… blocking chromatin assembly of newly-synthesized histones, via knockdown of the histone chaperones ASF1A, CAF-1 or a mutation that specifically prevents ASF1 binding to histones, hinders loading of Rad51 onto ssDNA during homologous recombination, as a consequence of reduced recruitment of the …
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Chromatin Dynamics During DNA Replication
… is replication coupled. Deletion of specific histone chaperones and chromatin remodelers perturbs this pathway. However, this can be compensated for by a transcription directed reorganisation of nascent chromatin. Our analysis of nascent chromatin has allowed us to investigate the mechanisms …
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A Two-colour Reporter Screen and Application to Cell Cycle Transcription
… this approach to probe cell cycle-regulation of histone gene transcription by introducing an HTA1 promoter-GFP reporter gene construct into an ordered array of ~4500 yeast deletion mutants. I scored defects in reporter gene expression for each mutant, generating a quantitative analysis of histone …
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Investigating the role of downy mildew effectors in host resistance and susceptibility
… was also found to interact with Arabidopsis histone chaperones (AtNAP1s) in the plant cytoplasm, which were observed to play a role in plant susceptibility to Hpa and partially to the necrotroph Botrytis cinerea, but not to the hemibiotrophs Pst and Phytophthora parasitica. AtNAP1s also …