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Showing 1 to 3 of 3 for “"histone H2B monoubiquitination"”.
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Investigations into the regulation of histone H2B monoubiquitination
… des Lysinrestes K120 von Histon H2B (H2Bub1) beispielsweise mit transkriptionell aktiven Genen in Verbindung gebracht werden. Zum einen konnte gezeigt werden, dass diese Modifikation die physikalischen Eigenschaften des Chromatins verändert, zum anderen dient sie als …
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REGULATION OF EUKARYOTIC TRANSCRIPTIONAL ELONGATION AND ASSOCIATED DNA REPAIR
… gene and hence transcriptional elongation is the monoubiquitination of histone H2B at lysine 123. A complex of an E2 conjugase, Rad6p, and an E3 ligase, Bre1p, is essential for this process. Consistent with the role of histone H2B monoubiquitination in promoting the association of RNAPII with the …
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Defining The Functions of Usp22 and Usp44 In Regulation of H2Bub1 Levels
<p>Aberrant levels of histone ubiquitination are involved in various human diseases including neurodegenerative disorders and cancers. Particularly, Histone H2B monoubiquitination (H2Bub1) is highly associated with gene regulation in both normal cells and diseases. Many deubiquitinases (mainly …