Global ETD Search
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Showing 1 to 4 of 4 for “"hirudin"”.
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In vitro-Untersuchungen zur Adsorption und Filtration von rekombinantem Hirudin : Vergleich unterschiedlicher Hämodialysatoren
Rekombinantes Hirudin ist ein sehr potenter direkter Thrombinantagonist, der zur Behandlung einer Heparin-induzierten Thrombozytopenie eingesetzt wird. Da Hirudin hauptsächlich renal eliminiert wird, ist seine Halbwertszeit bei Patienten mit eingeschränkter Nierenfunktion stark verlängert. Diese …
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Antithrombotic agents under flow conditions
… (UFH), low molecular weight heparin (LMWH) and hirudin. <br></br><br></br>Increasing flow rates increased TG, which was higher in the presence of ECM than in the presence of HUVEC. All anti thrombotic agents investigated were less effective in the presence of ECM.<br></br><br></br> The …
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Designing Allosteric Inhibitors of Thrombin
… drugs, including polymeric heparin, warfarin, hirudin, argatroban and the recently approved dabigatran, aim to reduce thrombin activity. There are several binding domains on thrombin including the active site, anion-binding exosites I and II, and the sodium binding site. We hypothesized that …
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Characterisation of protease activated receptors
… exosite, involved in binding to the hirudin-like domain of the thrombin receptor was grafted onto a recombinant single chain antibody using protein engineering. Molecular modelling indicated that incorporation of this loop into a framework region of the well-characterised …