Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"hippocampal neurogenesis"”.
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Impact of adult hippocampal neurogenesis on behavior
The role of adult hippocampal neurogenesis in behavior, especially contextual fear conditioning (CFC), is debated. Several studies demonstrated that blocking adult hippocampal neurogenesis in rodents impairs CFC, while several other studies failed to observe impairment. We sought to determine …
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The Role of Adult Hippocampal Neurogenesis in Morphine Addiction
… neuroplasticity within the hippocampus is adult neurogenesis, which occurs in the subgranular zone of the dentate gyrus. While a growing amount of literature has explored the effects of drugs of abuse on adult DG neurogenesis, the relationship between self-administered opiates and adult DG …
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Roles of HDACs and MEF2 in Adult Hippocampal Neurogenesis
… mechanisms that regulate this balance in adult hippocampal NSPCs can provide insight into basic neurogenesis principles important for tissue homeostasis and preventing tumor formation. Pharmacological inhibition of histone deacetylases (HDACs), a class of histone-modifying enzymes, have …
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The Role of Adult Hippocampal Neurogenesis in Morphine Addiction
… neuroplasticity within the hippocampus is adult neurogenesis, which occurs in the subgranular zone of the dentate gyrus. While a growing amount of literature has explored the effects of drugs of abuse on adult DG neurogenesis, the relationship between self-administered opiates and adult DG …
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The Role of Notch1 in Adult Hippocampal Neurogenesis and Function
Neurogenesis occurs throughout life in the hippocampal subgranular zone (SGZ) and is potently stimulated by exercise, but the underlying mechanisms are still poorly defined. Notch1 is a master regulator of developmental neurogenesis, yet its role in adult hippocampal neurogenesis is unclear. To …
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The Role of Glutamate Transporters in Early Postnatal Hippocampal Neurogenesis
Adult neurogenesis has been well-characterized in the subgranular zone (SGZ) of the hippocampal dentate gyrus however, early postnatal development of the dentate gyrus and changes in the neurogenic niche during this time have not been well-studied. Using a well-characterized transgenic mouse that …
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The Impact of Opioids and Opiates on Adult Hippocampal Neurogenesis
… (MOR) to similarly decrease survival of new hippocampal neurons. An exon 1 MOR knockout mouse showed increased survival of new neurons independent of effects on cell proliferation or cell death. In concordance with the increased numbers of granule cells maturing into neurons, knockout mice …
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Photobiomodulation of hippocampal neurogenesis for inducing resilience against Alzheimer’s disease
Adult hippocampal neurogenesis (AHN) is the process by which neural stem cells in the hippocampal dentate gyrus proliferate and differentiate to form new granule neurons that integrate into hippocampal circuitry, facilitating hippocampal plasticity throughout life. AHN is severely diminished in …
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CELLULAR ALTERATIONS OF ADULT HIPPOCAMPAL NEUROGENESIS IN THE FGF14−/− MOUSE MODEL
… decade, growing evidence indicates that adult neurogenesis (the production of functionally mature neurons from progenitor cells in the adult mammalian brain) is linked to the etiology of many neurodegenerative and psychiatric disorders. Studies have shown that neurogenesis is clearly a …
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Regulation of Adult Hippocampal Neurogenesis: Insights from Mouse Models of Dementia and Depression
While neurogenesis is largely complete by birth, the subgranular zone (SGZ) in the adult hippocampus continues to produce functional young neurons. The last decade has produced a multitude of research demonstrating that the process of SGZ neurogenesis is dynamically regulated. Stimuli that …
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Evaluating the regulation and function of adult mouse hippocampal neurogenesis induced from running
… a potent natural stimulator of adult mammalian hippocampal neurogenesis. Relatively little is known about how exercise stimulates neuron formation in the hippocampus, and even less is known about the possible functions of new neurons. Therefore, factors regulating the survival and the potential …
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The effect of voluntary exercise on adult hippocampal neurogenesis in maternally separated rats
… body of evidence suggests that a reduction in neurogenesis may be a key-mediating factor. Voluntary wheel running is a form of exercise that increases neurogenesis and decreases depression-like behaviour in rats. However, the exact molecular role of neurogenesis in exercise-induced …
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Activation of Early Neural Progenitors Is Required for Traumatic Brain Injury-Induced Hippocampal Neurogenesis
… mechanism is unknown. Exploration of post-natal neurogenesis in the hippocampus raises the possibility that adult-born neurons may contribute to cognitive recovery from TBI. Several studies in animal models that mimic TBI demonstrate there is enhanced generation of adult-born neurons in the …
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Effects of physical exercise and exercise-induced adult hippocampal neurogenesis on conditioned place preference for cocaine in mice
… addiction. It is known that exercise increases hippocampal neurogenesis. However, recently, conflicting reports have been published showing hippocampal neurogenesis to either be involved in or not contributory to learning and memory, and so the role of hippocampal neurogenesis in weakening …
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Aberrant hippocampal neurogenesis contributes to learning and memory deficits in a mouse model of repetitive mild traumatic brain injury
Adult hippocampal neurogenesis, or the process of creating new neurons in the dentate gyrus (DG) of the hippocampus, underlies learning and memory capacity. This cognitive ability is essential for humans to operate in their everyday lives, but cognitive disruption can occur in response to traumatic …
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Adult hippocampal neurogenesis: traumatic brain injury-induced dysregulation and therapeutic potentials of a novel non-invasive nano-pulsed laser treatment
Neurogenesis, a physiological process by which new neurons are generated from neural stem cells (NSC), occurs throughout life, subverting the old dogma stating to the inability of the adult brain to replace neurons. In the adult mammalian brain, neurogenesis takes place in the subventricular zone …
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Adult hippocampal neurogenesis: traumatic brain injury-induced dysregulation and therapeutic potentials of a novel non-invasive nano-pulsed laser treatment
Neurogenesis, a physiological process by which new neurons are generated from neural stem cells (NSC), occurs throughout life, subverting the old dogma stating to the inability of the adult brain to replace neurons. In the adult mammalian brain, neurogenesis takes place in the subventricular zone …
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Effect of Epigallocatechin-3-gallate on a pattern separation task and hippocampal neurogenesis in a mouse model of Down syndrome
… EGCG dose of 2-3 mg per day (90mg/ml) improved hippocampal-dependent task deficits in Ts65Dn mice. The current study investigated deficits in a radial arm maze pattern separation task in Ts65Dn mice. Pattern separation requires differentiation between similar memories acquired during learning …
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Investigations on the role of the gut microbiota in hippocampal neuroplasticity and behaviour throughout the lifespan
… to understand the biological controls of hippocampal neurogenesis. Hippocampal neuroplasticity is shaped by factors such as aging, diet, and psychological stress. However, the underlying mechanisms by which these factors influence neuroplasticity in the hippocampus are not fully known. In …
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The Role of Adult Neurogenesis in Cocaine Addiction
… of administration changes long-term effects on neurogenesis. In addition, it is unclear what role if any SGZ neurogenesis plays in initiating drug-taking or relapse behaviors, or whether changes in neurogenesis are merely side effects of drug-taking. I first examined effects of chronic cocaine …
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